scholarly journals Sodium-dependent accumulation of 5-hydroxytryptamine by rat blood platelets

1969 ◽  
Vol 37 (3) ◽  
pp. 680-688 ◽  
Author(s):  
J. M. SNEDDON
Keyword(s):  
Blood Platelets ◽  
Rat Blood ◽  
Sodium Dependent

Platelet Adhesion to Native Collagens Involves Proteoglycans and May Be a Two-Step Process

1987 ◽  
Vol 58 (02) ◽  
pp. 786-789 ◽  
Author(s):  
O Behnke
Keyword(s):  
Electron Microscope ◽  
Platelet Adhesion ◽  
Close Contact ◽  
Blood Platelets ◽  
Collagen Fibrils ◽  
Platelet Membrane ◽  
Step Process ◽  
Rat Blood ◽  
Wide Gap ◽  
Rat Tail

SummaryAdhesion of rat blood platelets to native rat tail collagen fibrils was studied in the electron microscope under conditions that preserved collagen-associated proteoglycans (CAPG). The CAPG molecules were aligned in chain-like configurations that encircled the fibrils with a 65 nm period; they appeared to coat the fibrils completely and extended 60-100 nm away from the fibril. The initial platelet-fibril contact occurred between the platelet glycocalyx and the CAPG of the fibrils i.e. between two surfaces with net-negative charges. When close contact was established between the fibril surface proper and the platelet membrane, CAPG were not identified in the area of contact, and the collagen-platelet distance was reduced to a ~10-12 nm wide gap traversed by delicate links in register with fibril periodicities.

Properties of [3H]diazepam binding sites on rat blood platelets

Life Sciences ◽  
1980 ◽  
Vol 27 (20) ◽  
pp. 1881-1888 ◽  
Author(s):  
James K.T. Wang ◽  
Takashi Taniguchi ◽  
Sydney Spector
Keyword(s):  
Binding Sites ◽  
Blood Platelets ◽  
Rat Blood

scholarly journals Specific binding sites for 5-hydroxytryptamine on rat blood platelets

1975 ◽  
Vol 150 (1) ◽  
pp. 129-132 ◽  
Author(s):  
A H Drummond ◽  
J L Gordon
Keyword(s):  
Binding Sites ◽  
Specific Binding ◽  
Blood Platelets ◽  
Rat Blood ◽  
Active Uptake ◽  
Specific Binding Sites

5-Hydroxytryptamine changes the shape of rat blood platelets by combination with a cinanserin-sensitive receptor which is not associated with the active uptake of 5-hydroxytryptamine. Binding of 5-hydroxy[3H]tryptamine to platelets at 4°C demonstrates the presence of three saturable sites, and the highest-affinity site is apparently this 5-hydroxytryptamine receptor.

The effect of beta-adrenoceptor blocking drugs on ‘ecto-ATPase’ activity of rat blood platelets

1982 ◽  
Vol 31 (19) ◽  
pp. 3122-3124 ◽  
Author(s):  
Peter Turčáni ◽  
Marian Turčáni ◽  
Daniel Bartko
Keyword(s):  
Atpase Activity ◽  
Blood Platelets ◽  
Rat Blood ◽  
Beta Adrenoceptor
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