scholarly journals Release of γ-aminobutyric acid and acetylcholine by neurotensin in guinea-pig ileum

1987 ◽  
Vol 90 (3) ◽  
pp. 545-551 ◽  
Author(s):  
Mitsuharu Nakamoto ◽  
Chikako Tanaka ◽  
Kohtaro Taniyama
Keyword(s):  
Guinea Pig ◽  
Aminobutyric Acid ◽  
Guinea Pig Ileum

scholarly journals STUDIES ON THE EFFECTS OF γ-AMINOBUTYRIC ACID ON THE ISOLATED GUINEA PIG ILEUM

1960 ◽  
Vol 10 (2) ◽  
pp. 167-182 ◽  
Author(s):  
AKIRA INOUYE ◽  
MASASHI FUKUYA ◽  
KAZUMICHI TSUCHIYA ◽  
TOSHIAKI TSUJIOKA
Keyword(s):  
Guinea Pig ◽  
Aminobutyric Acid ◽  
Guinea Pig Ileum

scholarly journals ANTI-STIMULANT ACTIONS OF γ-AMINOBUTYRIC ACID AND ITS DERIVATIVES ON THE GUINEA-PIG ILEUM

1961 ◽  
Vol 11 (5) ◽  
pp. 476-486 ◽  
Author(s):  
Hidehiko TAKAHASHI ◽  
Osamu IKEDA ◽  
Tokuhiro ITAYA ◽  
Fujio KOSHINO
Keyword(s):  
Guinea Pig ◽  
Aminobutyric Acid ◽  
Guinea Pig Ileum

Release of endogenous and labeled GABA from isolated guinea pig ileum

1983 ◽  
Vol 245 (5) ◽  
pp. G717-G721 ◽  
Author(s):  
K. Taniyama ◽  
Y. Miki ◽  
M. Kusunoki ◽  
N. Saito ◽  
C. Tanaka
Keyword(s):  
Guinea Pig ◽  
Gaba Release ◽  
Ringer Solution ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Tetraacetic Acid ◽  
Spontaneous Release ◽  
Guinea Pig Ileum ◽  
Fractional Rate ◽  
Endogenous Gaba

The release of gamma-aminobutyric acid (GABA) was studied by comparing the properties of labeled GABA released from preloaded preparations to those of endogenous GABA released from the isolated guinea pig ileum. The spontaneous release of endogenous GABA was 4.46 +/- 0.10 pmol X min-1 X g wet wt-1, and the fractional rate of endogenous GABA release was much lower. The ratio of evoked to spontaneous release of endogenous GABA was high compared with that of labeled GABA. The electrical transmural stimulation-evoked release of labeled and endogenous GABA was inhibited by superfusion with tetrodotoxin and Ca2+-free Krebs-Ringer solution containing 1 mM ethyleneglycol-bis(beta-aminoethylether)-N,N'-tetraacetic acid. Thus the nature of the stimulation-evoked release of labeled GABA was similar to that of endogenous GABA. These results indicate that the released GABA is neuronal in origin and provide additional evidence for the presence of GABA-ergic neurons in the guinea pig ileum.

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