Reply to Letter to the Editor: Thrombolytic Treatment and Mechanical Disruption for Prosthetic Valve Thrombosis in the Right Heart

2010 ◽  
Vol 34 (12) ◽  
pp. 1165-1165
Author(s):  
Shigeaki Aoyagi ◽  
Shuji Fukunaga ◽  
Hideki Teshima
Keyword(s):  
Prosthetic Valve ◽  
Thrombolytic Treatment ◽  
Right Heart ◽  
Prosthetic Valve Thrombosis ◽  
Mechanical Disruption ◽  
Letter To The Editor ◽  
Valve Thrombosis ◽  
The Right

scholarly journals Thrombolytic treatment for acute prosthetic valve thrombosis: Is it better than surgery?

2017 ◽  
Vol 16 (5) ◽  
pp. 162-164 ◽  
Author(s):  
Diego Araiza-Garaygordobil ◽  
Luis Antonio Aguilar-Rojas ◽  
Salvador Mendoza-García ◽  
Ricardo Leopoldo Barajas-Campos ◽  
Santiago Casal-Alonso ◽  
...  
Keyword(s):  
Prosthetic Valve ◽  
Thrombolytic Treatment ◽  
Prosthetic Valve Thrombosis ◽  
Valve Thrombosis ◽  
Better Than

scholarly journals Thrombolytic treatment of prosthetic valve thrombosis: a study using Urokinase

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Feng Huang ◽  
Yongrong Lan ◽  
Zhangbo Cheng ◽  
Zili Zhang ◽  
Fei Ren
Keyword(s):  
Thrombolytic Therapy ◽  
Prosthetic Valve ◽  
Treatment Time ◽  
Cerebral Haemorrhage ◽  
International Normalized Ratio ◽  
Thrombolytic Treatment ◽  
Mitral Valves ◽  
Prosthetic Valve Thrombosis ◽  
Valve Thrombosis ◽  
Haemodynamic Improvement

Abstract Objective We analysed the efficacy and safety of thrombolytic therapy with urokinase in patients with prosthetic valve thrombosis. Methods Twenty-three patients with valve thrombosis received thrombolytic treatment using urokinase. First, a 250,000 IU intravenous bolus injection was administered as a loading dose, followed by intravenous infusion of 100,000 IU/h for 10 h and anticoagulation with low molecular weight heparin every day. The maximum treatment time was 5 days, i.e., until the transvalvular pressure gradient was normal or close to normal. Transthoracic echocardiography (TTE) was used every 12 h to monitor whether the thrombus was reduced and whether there was haemodynamic improvement. Routine blood tests, the prothrombin time (PT), international normalized ratio (INR) and complications were observed every day. Results Sixteen (69.6%) patients were successfully treated with thrombolytic therapy: 2/2 (100%) aortic valves and 14/21 (66.7%) mitral valves. The partial success rate of this study was 13.0% (3/23). Four patients did not show any improvement in haemodynamics. Two cases had slight urine haemorrhage. One patient died of severe cerebral haemorrhage and shock. The overall mortality was 13.0% (3/23), including two patients who died after subsequent surgery. Conclusion Urokinase is more convenient and successful in the treatment of PVT. More experience may make TT the optimal treatment for PVT, especially in high-risk surgical situations.

Thrombolytic Treatment of Prosthetic Valve Thrombosis

2001 ◽  
Vol 9 (1) ◽  
pp. 38
Author(s):  
Yong Min Kim ◽  
Yong Whi Park ◽  
Ju Yup Han ◽  
Dong Heon Yang ◽  
Young Bae Seo ◽  
...  
Keyword(s):  
Prosthetic Valve ◽  
Thrombolytic Treatment ◽  
Prosthetic Valve Thrombosis ◽  
Valve Thrombosis

scholarly journals Mechanical Pulmonary Valve Thrombosis: Recurrence and Response to Thrombolytic Therapy

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Zahra Hosseini
Keyword(s):  
Thrombolytic Therapy ◽  
Heart Valve ◽  
Prosthetic Valve ◽  
Pulmonary Valve ◽  
Prosthetic Valve Thrombosis ◽  
Valve Thrombosis ◽  
The Right

Prosthetic valve thrombosis (PVT) is a serious complication in the left-sided heart valve. However, in the right-side position, this complication may be completely asymptomatic or accompanied by only a few symptoms. Research on the prevalence of thrombosis in right-sided valves is still insufficient. We sought to retrospectively report our center’s experience concerning PVT and its management outcomes.

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