Fulminant hepatic failure as the presenting form of type 1 autoimmune hepatitis in the elderly

2002 ◽  
Vol 97 (5) ◽  
pp. 1265-1266 ◽  
Author(s):  
Eduardo Redondo-Cerezo ◽  
Flor Nogueras-Lopez ◽  
Rafael Martin-Vivaldi ◽  
Esperanza Egea Simon
Keyword(s):  
Autoimmune Hepatitis ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
The Elderly

Oxaprozin-Induced Fulminant Hepatitis

1994 ◽  
Vol 28 (10) ◽  
pp. 1159-1161 ◽  
Author(s):  
Preston P. Purdum ◽  
Stacey L. Shelden ◽  
John W. Boyd ◽  
Mitchell L. Shiffman
Keyword(s):  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Fulminant Hepatitis ◽  
The Elderly ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Antiinflammatory Drugs ◽  
Drug Induced ◽  
Hepatic Transaminase ◽  
Long Acting ◽  
Work Up

OBJECTIVE: To report oxaprozin-induced fulminant hepatic failure. CASE SUMMARY: A 56-year-old woman was admitted with fulminant hepatic failure. Work-up for potential etiologies was negative except for the use of oxaprozin for the preceding two months. Results of premortem liver biopsy were consistent with drug-induced hepatic injury similar to that previously reported with diclofenac. DISCUSSION: Although the literature describes elevation in hepatic transaminase concentrations associated with oxaprozin, fulminant hepatic failure has not been described previously. CONCLUSIONS: Elevations in hepatic transaminase concentrations and now fulminant hepatic failure have been shown to occur with oxaprozin, as previously seen with other nonsteroidal antiinflammatory drugs (NSAIDs). Transaminitis is a known adverse effect of NSAID use, but is usually mild and reversible with discontinuation of drug. Transaminitis may be more likely to occur in the elderly, in patients receiving concurrent potentially hepatotoxic medications, and possibly with the newer long-acting NSAIDs. The existence of fulminant hepatitis, although rare, supports the need for monitoring liver function enzymes during NSAID therapy.

Ceftriaxone Induced Acute Autoimmune Hepatitis and Fulminant Hepatic Failure

2011 ◽  
Vol 106 ◽  
pp. S291
Author(s):  
Usman Cheema ◽  
Mosaab Ahmed ◽  
Carrie Vogler ◽  
Edgard Cumpa ◽  
Aman Ali
Keyword(s):  
Autoimmune Hepatitis ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure

Subfulminant hepatic failure in autoimmune hepatitis type 1: an unusual form of presentation

1997 ◽  
Vol 27 (3) ◽  
pp. 578-582 ◽  
Author(s):  
Denise Herzog ◽  
Andrée-Marie Rasquin-Weber ◽  
Dominique Debray ◽  
Fernando Alvarez
Keyword(s):  
Autoimmune Hepatitis ◽  
Hepatic Failure ◽  
Unusual Form ◽  
Autoimmune Hepatitis Type 1

Fulminant hepatic failure in the elderly: A clinicopathological study of autopsy cases aged over 65 years

2000 ◽  
Vol 50 (2) ◽  
pp. 98-105 ◽  
Author(s):  
Motoji Sawabe ◽  
Tomio Arai ◽  
Yukiyoshi Esaki ◽  
Toshio Fukazawa ◽  
Kaiyo Takubo ◽  
...  
Keyword(s):  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
The Elderly ◽  
Clinicopathological Study

The Unique Occurrence of Hepatic Failure From Type 1 Autoimmune Hepatitis With Concurrent Brain Abscess

2003 ◽  
Vol 36 (3) ◽  
pp. 414-417 ◽  
Author(s):  
Susan J. Pacini-Edelstein ◽  
Ron J. Bahar ◽  
Sue V. McDiarmid ◽  
Jorge H. Vargas ◽  
Martin G. Martin ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Brain Abscess ◽  
Hepatic Failure
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