Arachidonate Metabolism is Changed by Dipyridamole in Guinea Pig Isolated Lungs

2009 ◽  
Vol 50 (5) ◽  
pp. 374-378 ◽  
Author(s):  
Pekka Uotila
Keyword(s):  
Guinea Pig ◽  
Arachidonate Metabolism ◽  
Isolated Lungs

Tachykinin recovery during postmortem bronchoconstriction in guinea pig lungs

1991 ◽  
Vol 70 (3) ◽  
pp. 1215-1219 ◽  
Author(s):  
M. A. Martins ◽  
S. A. Shore ◽  
J. M. Drazen
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Neutral Endopeptidase ◽  
Neurokinin A ◽  
Opening Pressure ◽  
Airway Opening ◽  
Isolated Lungs ◽  
Peak Value

We examined the role of substance P (SP) and neurokinin A (NKA) in the postmortem bronchoconstriction in guinea pig lungs using isolated lungs superfused via the trachea. Airway opening pressure (Pao) during superfusion was monitored and the superfusate collected for analysis of SP- and NKA-like immunoreactivities (SP-LI and NKA-LI, respectively). Peak Pao (39.0 +/- 3.9 cmH2O) was reached 10 min after starting superfusion; Pao decreased slowly thereafter, reaching only 9.9 +/- 2.2% of the peak value 2 h after starting superfusion (P less than 0.005); 12.6 +/- 2.6 and 34.0 +/- 9.7 fmol of SP-LI and NKA-LI, respectively, were found in the fraction corresponding to 10-20 min of superfusion. Recovered immunoreactivities decreased to 5.2 +/- 0.3 and 9.3 +/- 1.8 fmol of SP-LI and NKA-LI, respectively, in the fraction corresponding to 110-120 min of superfusion (P less than 0.05). Inhibition of neutral endopeptidase with thiorphan resulted in significantly greater increases in Pao (P less than 0.005) and augmentation of the recovery of SP-LI and NKA-LI (P less than 0.05 and P less than 0.001, respectively). Capsaicin treatment of animals 7-10 days before the removal of their lungs abolished the increase in Pao during superfusion and resulted in a significant decrease in the amount of SP-LI and NKA-LI recovered. Our data confirm that tachykinin release occurs during postmortem bronchoconstriction in guinea pig lungs and, furthermore, that tachykinin degradation by NEP modulates the intensity of this response.

scholarly journals TOLERANCE TO SYMPATHOMIMETIC BRONCHODILATORS IN GUINEA-PIG ISOLATED LUNGS FOLLOWING CHRONIC ADMINISTRATION in vivo

1975 ◽  
Vol 55 (4) ◽  
pp. 547-554 ◽  
Author(s):  
CHRISTINE J. BENOY ◽  
M.S. EL-FELLAH ◽  
R. SCHNEIDER ◽  
O.L. WADE
Keyword(s):  
Guinea Pig ◽  
Chronic Administration ◽  
Isolated Lungs

scholarly journals ATROPINE INHIBITS THROMBOXANE A2 GENERATION IN ISOLATED LUNGS OF THE GUINEA-PIG

1980 ◽  
Vol 68 (3) ◽  
pp. 467-472 ◽  
Author(s):  
F. BERTI ◽  
G.C. FOLCO ◽  
A. GIACHETTI ◽  
S. MALANDRINO ◽  
G. OMINI ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Thromboxane A2 ◽  
Isolated Lungs

Tracheobronchial microvessels perfused via the pulmonary artery in guinea-pig isolated lungs

1987 ◽  
Vol 129 (3) ◽  
pp. 445-446 ◽  
Author(s):  
F. KRÖLL ◽  
J.-A. KARLSSON ◽  
C. G. A. PERSSON
Keyword(s):  
Pulmonary Artery ◽  
Guinea Pig ◽  
Isolated Lungs

The synthesis of eicosanoids induced by anaphylaxis in guinea-pig isolated lungs perfused via the trachea

1986 ◽  
Vol 130 (3) ◽  
pp. 249-256 ◽  
Author(s):  
Gilberto De Nucci ◽  
John A. Salmon ◽  
Salvador Moncada
Keyword(s):  
Guinea Pig ◽  
Isolated Lungs
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