Studies of Blood-pressure Regulation III. Dynamics of Arterial Blood Pressure on Carotid-sinus Nerve Stimulation

1971 ◽  
Vol 81 (1) ◽  
pp. 96-109 ◽  
Author(s):  
P. A. Öberg ◽  
U. Sjöstrand
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Nerve Stimulation ◽  
Carotid Sinus ◽  
Blood Pressure Regulation ◽  
Pressure Regulation ◽  
Carotid Sinus Nerve ◽  
Arterial Blood ◽  
Carotid Sinus Nerve Stimulation

scholarly journals Sex- and age-based differences in the effect of central serotonin on arterial blood pressure regulation

2020 ◽  
Vol 129 (6) ◽  
pp. 1310-1323
Author(s):  
Jennifer L. Magnusson ◽  
Craig A. Emter ◽  
Kevin J. Cummings
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Nrem Sleep ◽  
Blood Pressure Regulation ◽  
Pressure Regulation ◽  
Adult Rats ◽  
Arterial Blood ◽  
Serotonin Neurons ◽  
Older Males

The role of serotonin in arterial blood pressure (ABP) regulation across states of vigilance is unknown. We hypothesized that adult rats devoid of CNS serotonin (TPH2−/−) have low ABP in wakefulness and NREM sleep, when serotonin neurons are active. However, TPH2−/− rats experience higher ABP than TPH2+/+ rats in wakefulness and REM only, a phenotype present only in older males and not females. CNS serotonin may be critical for preventing high ABP in males with aging.

Modulation of respiratory responses to carotid sinus nerve stimulation by brain hypoxia

1992 ◽  
Vol 73 (5) ◽  
pp. 2166-2171 ◽  
Author(s):  
J. E. Melton ◽  
Q. P. Yu ◽  
J. A. Neubauer ◽  
N. H. Edelman
Keyword(s):  
Blood Pressure ◽  
Nerve Stimulation ◽  
Carotid Sinus ◽  
Periodic Breathing ◽  
Carotid Sinus Nerve ◽  
Respiratory Response ◽  
Carotid Sinus Nerve Stimulation ◽  
Best Fit ◽  
Pressure Controlled ◽  
Respiratory Responses

This study examines the effect of progressive isocapnic CO hypoxemia on respiratory afterdischarge and the phrenic neurogram response to supramaximal carotid sinus nerve (CSN) stimulation. Twelve anesthetized, vagotomized, peripherally chemodenervated, ventilated cats with blood pressure controlled were studied. During isocapnic hypoxemia, the amplitude of the phrenic neurogram was progressively depressed. In contrast, the increase in peak phrenic amplitude produced by CSN stimulation was unchanged, suggesting that the central respiratory response to CSN stimulation is unaffected by progressive hypoxemia. The time constant of respiratory afterdischarge (tau) was calculated from best-fit plots of phrenic amplitude vs. time after cessation of CSN stimulation. Under control conditions the value of tau was 57.7 +/- 3 (SE) s (n = 12). During progressive isocapnic hypoxemia, tau decreased as a linear function of arterial O2 content (CaO2) such that a 40% reduction of CaO2 resulted in a 48% reduction in tau. This reduction of respiratory afterdischarge may contribute to the genesis of periodic breathing during hypoxia.

Sign in / Sign up

Export Citation Format

Share Document