Transient Ischemic Attack

The transient ischemic attack is a neurological emergency which is a clinical view of focal cerebral, retinal, or spinal dysfunction that lasts less than an hour, without any detectable acute infarction in neurological imaging methods. TIA is a serious warning for ischemic stroke, and this risk is particularly high in the first 48 hours. Following TIAs, approximately 10-15% of patients undergo stroke in 90 days and about half of these patients suffer a stroke in the first two days. Neuroimaging and laboratory studies should be performed quickly to reveal the etiology and to reduce the risk of stroke that may develop in patients present with TIA. Therapeutic and preventive interventions should be started as soon as possible. With early diagnosis and treatment, the risk of a 90-day stroke in these patients can be reduced by 80%. In addition to antiplatelet and anticoagulant treatments, aggressive control of blood pressure, regulation of blood sugar, statin, dietary recommendations, exercise, and managing the other underlying specific conditions should be started quickly.

The Bidirectional Signal Communication of Microbiota-Gut-Brain Axis in Hypertension

Hypertension is a critical risk factor of cardiovascular diseases. A new concept of microbiota-gut-brain axis has been established recently, mediating the bidirectional communication between the gut and its microbiome and the brain. Alterations in bidirectional interactions are believed to be involved in the blood pressure regulation. Neuroinflammation and increased sympathetic outflow act as the descending innervation signals from the brain. Increased sympathetic activation plays a recognized role in the genesis of hypertension. The present evidence demonstrates that gut dysbiosis is associated with central nervous system neuroinflammation. However, how the gut influences the brain remains unclear. We reviewed the roles of neuroinflammation and gut microbiota and their interactions in the pathogenesis of hypertension and described the ascending signaling mechanisms behind the microbiota-gut-brain axis in detail. Additionally, the innovative prohypertensive mechanisms of dietary salt through the microbiota-gut-brain axis are summarized. The bidirectional communication mechanisms were proposed for the first time that the descending signals from the brain and the ascending connections from the gut form a vicious circle of hypertension progression, acting as a premise for hypertension therapy.

Human intrinsic choroidal neurons do not alter the expression of intrinsic markers in response to pressure

BackgroundThe choroid is densely innervated by all parts of the autonomic nervous system and further harbours a network of local nerve cells, the intrinsic choroidal neurons (ICN). Their function in ocular control is currently unknown. While morphological data assume a role in intraocular pressure regulation, we here test if increased pressure on isolated choroids may activate ICN.MethodsDonor tissue was transferred into a pressurisable tissue culture chamber, and nasal and temporal choroid halves incubated for 1 or 4 hours, with pressures set to 15 or 50 mm Hg, followed by qRT-PCR expression analysis of the ICN-specific markers VIP, UCN, NOS1, UCH-L1. POL2-normalised data in the different pressure settings, incubation times and localisations were statistically analysed.ResultsThe presence of the ICN-specific markers VIP, UCN, NOS1, UCH-L1 was confirmed using immunohistochemistry, and mRNA of all markers was detected in all experimental conditions. Marker analysis revealed no significant changes of mRNA expression levels between 15 and 50 mm Hg in the different incubation times. When comparing all samples over all experimental conditions, a significant increase of VIP and NOS1 mRNA was detected in temporal versus nasal choroids.ConclusionIn this functional analysis of human ICN in vitro, higher amounts of VIP and NOS1 mRNA were detected in the temporal choroid, that is, the choroidal site with ICN accumulation. Further, our data indicate that elevated pressure is apparently not able to trigger ICN responses via the investigated markers. Alternative markers and stimuli need to be investigated in upcoming studies in order to unravel ICN function.

Evaluation of service pressure regulation strategy on the performance of a rural water network based on pulse demand; using the method of characteristics

Reducing the occurrence of pipe bursts, reducing leakage, and reducing energy consumption are the three main goals in implementing pressure control programs in water distribution networks. Service Pressure Regulation Strategy is an evolved approach that encompasses all goals of pressure management. This paper has investigated this approach in a rural network with hydraulic complexities as a case study so that some parts of the network have excess pressure and other low pressure. A computer code based on the Method of Characteristics (MOC) has been developed for network hydraulic analysis. The generated code analyzes unsteady flow, pressure-driven demand analysis, and dynamic adjustment of pressure control valves based on the target node. Also, the experimental results of a laboratory network have been applied to validate and calibrate the numerical simulation. In addition, by measuring the flow rate and pressure of the network and the results of the MNF method, three consumption patterns were used to generate pulsed nodal demands. Studies show that creating Pressure-Management Areas by hydraulic analysis by MOC will determine the best control strategies. The mean pressure has decreased 54% by applying this strategy. Furthermore, the average fluctuations of pressure have reduced from 9.7 meters to 3.5 meters.

Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease

Here we present a modular agent-based mathematical model of the human cardiovascular and renal systems. It integrates the previous models primarily developed by A. C. Guyton, F. Karaaslan, K. M. Hallow, and Y. V. Solodyannikov. We performed the model calibration to find an equilibrium state within the normal vital sign ranges for a healthy adult. We verified the model’s abilities to reproduce equilibrium states with abnormal physiological values related to different combinations of cardiovascular diseases (such as systemic hypertension, chronic heart failure, pulmonary hypertension, etc.). For the model creation and validation, we involved over 200 scientific studies covering known models of the human cardiovascular and renal functions, biosimulation platforms, and clinical measurements of physiological quantities in normal and pathological conditions. We compiled detailed documentation describing all equations, parameters and variables of the model with justification of all formulas and values. The model is implemented in BioUML and available in the web-version of the software.

Study on the Structural Configurations and Pressure Regulation Characteristics of the Automatic Pressure Regulating Valve in the Electronically Controlled Pneumatic Brake System of Commercial Vehicles

Based on the classification of automated driving by the SAE (Society of Automotive Engineers) and the working principle of the ECPBS (Electronically Controlled Pneumatic Brake system), the requirements and the control modes of the APRV (Automatic Pressure Regulating Valve) were concluded. Four structural configurations for APRV were proposed to meet the requirements of the ECPBS. To study the pressure regulating characteristics of the APRV of different structure configurations, a simulation model was established, and a test bench was built. Through experiments, the correctness and the reliability of the simulation model were verified. The pressure regulation characteristics of the APRV of different structure configurations under different control conditions were revealed, and the suitable levels in the SAE automated driving classifications for automatic pressure regulators of different structure configurations were determined; thus, the theoretical underpinning to improve driving safety and develop automated driving was provided.