Association of CYP2C9*3 with phenytoin-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: A systematic review and meta-analysis

2017 ◽  
Vol 43 (3) ◽  
pp. 408-413 ◽  
Author(s):  
X. Wu ◽  
W. Liu ◽  
W. Zhou
Keyword(s):  
Systematic Review ◽  
Toxic Epidermal Necrolysis ◽  
Meta Analysis ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome

scholarly journals Association of HLA-B*5801 allele and allopurinol-induced stevens johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis

2011 ◽  
Vol 12 (1) ◽  
Author(s):  
Ratchadaporn Somkrua ◽  
Elizabeth E Eickman ◽  
Surasak Saokaew ◽  
Manupat Lohitnavy ◽  
Nathorn Chaiyakunapruk
Keyword(s):  
Systematic Review ◽  
Toxic Epidermal Necrolysis ◽  
Meta Analysis ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome

Stevens–Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis

2021 ◽  
Vol 30 (12) ◽  
pp. 1012-1019
Author(s):  
Khosrow S Houschyar ◽  
Christian Tapking ◽  
Mimi R Borrelli ◽  
Behrus Puladi ◽  
Mark Ooms ◽  
...  
Keyword(s):  
Systematic Review ◽  
Toxic Epidermal Necrolysis ◽  
Clinical Studies ◽  
English Language ◽  
Meta Analysis ◽  
Treatment Protocol ◽  
Stevens Johnson Syndrome ◽  
Inclusion Criteria ◽  
Johnson Syndrome ◽  
Pubmed Database

Objective: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and severe skin and mucosal reactions that are associated with high mortality. Despite the severity, an evidence-based treatment protocol for SJS/TEN is still lacking. Method: In this systematic review and meta-analysis, the PubMed database was searched using the following terms: [Stevens–Johnson syndrome] OR [toxic epidermal necrolysis] AND [therapy] OR [treatment] over a 20-year period (1999–2019) in the German and English language. All clinical studies reporting on the treatment of SJS/TEN were included, and epidemiological and diagnostic aspects of treatment were analysed. A meta-analysis was conducted on all comparative clinical studies that met the inclusion criteria. Results: A total of 88 studies met the inclusion criteria, reporting outcomes in 2647 patients. Treatment was either supportive or used systemic corticosteroid, intravenous immunoglobulin, plasmapheresis, cyclosporine, thalidomide or cyclophosphamide therapy. The meta-analysis included 16 (18%) studies, reporting outcomes in 976 (37%) patients. Systemic glucocorticoids showed a survival benefit for SJS/TEN patients in all analyses compared with other forms of treatment. Cyclosporine treatment also showed promising results, despite being used in a small cohort of patients. No beneficial effects on mortality could be demonstrated for intravenous immunoglobulins. Conclusion: Glucocorticoids and cyclosporine may be tentatively recommended as the most promising immunomodulatory therapies for SJS/TEN, but these results should be investigated in future prospective controlled trials.

scholarly journals HLA genotypes and cold medicine-induced Stevens–Johnson syndrome/toxic epidermal necrolysis with severe ocular complications: a systematic review and meta-analysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Wimonchat Tangamornsuksan ◽  
Sirikan Chanprasert ◽  
Phenphechaya Nadee ◽  
Saowalak Rungruang ◽  
Natnaree Meesilsat ◽  
...  
Keyword(s):  
Systematic Review ◽  
Toxic Epidermal Necrolysis ◽  
Meta Analysis ◽  
Stevens Johnson Syndrome ◽  
Ocular Complications ◽  
Johnson Syndrome ◽  
Hla Genotypes
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