Protective effect and potential mechanism of Schwann cell‐derived exosomes on mechanical damage of rat dorsal root ganglion cells

2021 ◽  
Author(s):  
Guotao Huang ◽  
Ming Hu ◽  
Danhua Lu ◽  
Li Hong
Keyword(s):  
Dorsal Root Ganglion ◽  
Schwann Cell ◽  
Protective Effect ◽  
Dorsal Root ◽  
Ganglion Cells ◽  
Mechanical Damage ◽  
Potential Mechanism ◽  
Dorsal Root Ganglion Cells

scholarly journals Effects of RSC96 Schwann Cell-Derived Exosomes on Proliferation, Senescence, and Apoptosis of Dorsal Root Ganglion Cells In Vitro

2018 ◽  
Vol 24 ◽  
pp. 7841-7849 ◽  
Author(s):  
Min Zhou ◽  
Ming Hu ◽  
Songming He ◽  
Bingshu Li ◽  
Cheng Liu ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Schwann Cell ◽  
Dorsal Root ◽  
Ganglion Cells ◽  
Dorsal Root Ganglion Cells

Effect of gold nanoparticle treated dorsal root ganglion cells on peripheral neurite differentiation

2021 ◽  
Vol 74 ◽  
pp. 105175
Author(s):  
Pallavi Madhusudanan ◽  
Chinnu Jerard ◽  
Neeraj Katiyar ◽  
Gayathri Raju ◽  
Sahadev A. Shankarappa
Keyword(s):  
Dorsal Root Ganglion ◽  
Gold Nanoparticle ◽  
Dorsal Root ◽  
Ganglion Cells ◽  
Dorsal Root Ganglion Cells

Gangliosides attenuate vincristine neurotoxicity on dorsal root ganglion cells

1993 ◽  
Vol 16 (1) ◽  
pp. 11-14 ◽  
Author(s):  
Kouji Houi ◽  
Soichiro Mochio ◽  
Takaaki Kobayashi
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Ganglion Cells ◽  
Dorsal Root Ganglion Cells

Reactions of dorsal root ganglion cells to section of peripheral and central processes

1940 ◽  
Vol 73 (3) ◽  
pp. 489-502 ◽  
Author(s):  
William Kendrick Hare ◽  
Joseph C. Hinsey
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Ganglion Cells ◽  
Dorsal Root Ganglion Cells

Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat

1995 ◽  
Vol 73 (5) ◽  
pp. 1811-1820 ◽  
Author(s):  
Y. Xie ◽  
J. Zhang ◽  
M. Petersen ◽  
R. H. LaMotte
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Ganglion Cells ◽  
Threshold Concentration ◽  
Injury Site ◽  
Functional Changes ◽  
C Fibers ◽  
Excitatory Responses ◽  
Dorsal Root Ganglion Cells ◽  
Thermal Stimuli

1. We studied the effects of a chronic nerve constriction on the evoked responses in dorsal root fibers in the rat to norepinephrine and to thermal stimuli applied either to the dorsal root ganglion (DRG) or the site of nerve injury. We recorded a total of 59 C fibers, 15 A delta-fibers, and 46 A beta-fibers from the L5 dorsal root of the rats 11-52 days after a loose ligation of the ipsilateral sciatic nerve. Most fibers were identified by the presence of spontaneous activity (SA) that originated partially at and/or proximal to the injury site. In addition, we recorded 20 C fibers, 1 A delta-fiber, and 28 A beta-fibers from the dorsal roots of normal, uninjured neurons. 2. In nerve-injured rats, the SA of some C fibers was generally increased by cooling and decreased by heating either site. In contrast, the SA of most A beta-fibers was increased by heating either the injury site or the DRG. Cooling the DRG decreased SA in A beta-fibers, whereas cooling the injury site typically had no effect. Excitatory responses were not evoked in any fiber group when the same thermal stimuli were applied to the nerve or DRG tested in normal, uninjured rats. 3. Norepinephrine (< 0.5 mM) applied either to the injury site or the DRG increased the SA of most C fibers and A delta-fibers but only a minority of A beta-fibers in previously injured nerves. The threshold concentration for excitation of the DRG somata of C fibers was 0.01 mM. No effects were found for fibers in uninjured nerves. 4. The effect of norepinephrine was blocked by a pretreatment with yohimbine, an alpha 2-blocker, but not with prazosin, an alpha 1-blocker. 5. Stimulation of the sympathetic trunk (L2-L3) excited most C fibers and a minority of A beta-fibers. In contrast, the SA of a minority of C fibers and A beta-fibers was depressed during sympathetic stimulation. 6. After a chronic nerve constriction the DRG becomes a source of abnormal activity modulated by sympathetically released norepinephrine acting on alpha 2 receptors in DRG somata. This neuropathic activity may contribute to cutaneous pain and hyperalgesia.

Dorsal Root Ganglion Cells and Their Processes

1991 ◽  
pp. 47-78 ◽  
Author(s):  
W. D. Willis ◽  
R. E. Coggeshall
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Ganglion Cells ◽  
Dorsal Root Ganglion Cells

scholarly journals Gymnopilin-a substance produced by the hallucinogenic mushroom, Gymnopilus junonius-mobilizes intracellular Ca2+ in dorsal root ganglion cells

2012 ◽  
Vol 33 (2) ◽  
pp. 111-118 ◽  
Author(s):  
Shunsuke Miyazaki ◽  
Naoki Kitamura ◽  
Aiko Nishio ◽  
Saki Tanaka ◽  
Tomohiko Kayano ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Ganglion Cells ◽  
Dorsal Root Ganglion Cells

scholarly journals Paclitaxel and vinorelbine, evoked the release of substance P from cultured rat dorsal root ganglion cells through different PKC isoform-sensitive ion channels

2009 ◽  
Vol 57 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Kanako Miyano ◽  
He-Bin Tang ◽  
Yoki Nakamura ◽  
Norimitsu Morioka ◽  
Atsuko Inoue ◽  
...  
Keyword(s):  
Ion Channels ◽  
Substance P ◽  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Ganglion Cells ◽  
Dorsal Root Ganglion Cells
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