The usefulness of combined brain perfusion single-photon emission computed tomography, Dopamine-transporter single-photon emission computed tomography, and 123 I-metaiodobenzylguanidine myocardial scintigraphy for the diagnosis of dementia with Lewy bodies

2017 ◽  
Vol 17 (4) ◽  
pp. 247-255 ◽  
Author(s):  
Seiju Kobayashi ◽  
Kanae Makino ◽  
Shigeki Hatakeyama ◽  
Takao Ishii ◽  
Masaru Tateno ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Lewy Bodies ◽  
Brain Perfusion ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Emission Computed ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

Efficacy of Single Photon Emission Computed Tomography in Differentiating Dementia with Lewy Bodies - A Review of Neurotransmitter and Perfusion Imaging

2009 ◽  
Vol 4 (1) ◽  
pp. 82 ◽  
Author(s):  
Shirlony Morgan ◽  
Zuzana Walker ◽  
◽  
Keyword(s):  
Computed Tomography ◽  
Dementia With Lewy Bodies ◽  
Single Photon ◽  
Photon Emission ◽  
Lewy Bodies ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Emission Computed ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

The accuracy of the clinical diagnosis of dementia with Lewy bodies continues to be relatively poor. Several neuroimaging techniques have been used to facilitate a more accurate diagnosis. Thus far, functional neuroimaging has provided the most help. This article concentrates on the use of single photon emission computed tomography (SPECT) and reports on the efficacy data available from studies investigating cerebral perfusion, cardiac scintigraphy and dopaminergic neurotransmission. The results from perfusion studies are inconsistent. Cardiac scintigraphy shows more promise, but it is not yet known whether co-morbid cardiac conditions, which are common in the elderly, will limit the clinical use of this method. The radioligand123I–FP-CIT binds to dopamine transporters in nigrostriatal nerve terminals and provides a way of assessing the neurodegeneration caused by Lewy body pathology. Abnormal123I–FP-CIT has been shown to have high sensitivity and specificity in an autopsy study and a large multicentre trial. This article aims to give an overview of the topic.

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