scholarly journals The loss of slow skeletal muscle isoform of troponin T in spindle intrafusal fibres explains the pathophysiology of Amish nemaline myopathy

2019 ◽  
Vol 597 (15) ◽  
pp. 3999-4012 ◽  
Author(s):  
Kentaro Oki ◽  
Bin Wei ◽  
Han‐Zhong Feng ◽  
Jian‐Ping Jin
Keyword(s):  
Skeletal Muscle ◽  
Troponin T ◽  
Nemaline Myopathy ◽  
Slow Skeletal Muscle ◽  
Intrafusal Fibres

scholarly journals Cellular Fate of Truncated Slow Skeletal Muscle Troponin T Produced by Glu180Nonsense Mutation in Amish Nemaline Myopathy

2005 ◽  
Vol 280 (14) ◽  
pp. 13241-13249 ◽  
Author(s):  
Xin Wang ◽  
Qi-Quan Huang ◽  
Mark T. Breckenridge ◽  
Aihua Chen ◽  
Thomas O. Crawford ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Troponin T ◽  
Nemaline Myopathy ◽  
Slow Skeletal Muscle ◽  
Cellular Fate

scholarly journals Truncation by Glu180Nonsense Mutation Results in Complete Loss of Slow Skeletal Muscle Troponin T in a Lethal Nemaline Myopathy

2003 ◽  
Vol 278 (28) ◽  
pp. 26159-26165 ◽  
Author(s):  
Jian-Ping Jin ◽  
Marco A. Brotto ◽  
M. Moazzem Hossain ◽  
Qi-Quan Huang ◽  
Leticia S. Brotto ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Troponin T ◽  
Nemaline Myopathy ◽  
Complete Loss ◽  
Slow Skeletal Muscle

scholarly journals Toad Heart Utilizes Exclusively Slow Skeletal Muscle Troponin T

2012 ◽  
Vol 287 (35) ◽  
pp. 29753-29764 ◽  
Author(s):  
Han-Zhong Feng ◽  
Xuequn Chen ◽  
M. Moazzem Hossain ◽  
Jian-Ping Jin
Keyword(s):  
Skeletal Muscle ◽  
Troponin T ◽  
Slow Skeletal Muscle

scholarly journals Conformational modulation of slow skeletal muscle troponin T by an NH2-terminal metal-binding extension

2000 ◽  
Vol 279 (4) ◽  
pp. C1067-C1077 ◽  
Author(s):  
Jian-Ping Jin ◽  
Aihua Chen ◽  
Ozgur Ogut ◽  
Qi-Quan Huang
Keyword(s):  
Skeletal Muscle ◽  
Monoclonal Antibody ◽  
Metal Binding ◽  
Metal Ion ◽  
Troponin I ◽  
Troponin T ◽  
Terminal Region ◽  
Sequence Motif ◽  
Fast Skeletal Muscle ◽  
Slow Skeletal Muscle

Troponin T (TnT) is an essential element in the thin filament Ca2+-regulatory system controlling striated muscle contraction. Alternative RNA splicing generates developmental and muscle type-specific TnT isoforms differing in the hypervariable NH2-terminal region. Using avian fast skeletal muscle TnT containing a metal-binding segment, we have demonstrated a role of the NH2-terminal domain in modulating the conformation of TnT (Wang J and Jin JP. Biochemistry 37: 14519–14528, 1998). To further investigate the structure-function relationship of TnT, the present study constructed and characterized a recombinant protein in which the metal-binding peptide present in avian fast skeletal muscle TnT was fused to the NH2 terminus of mouse slow skeletal muscle TnT. Metal ion or monoclonal antibody binding to the NH2-terminal extension induced conformational changes in other domains of the model TnT molecule. This was shown by the altered affinity to a monoclonal antibody against the COOH-terminal region and a polyclonal antiserum recognizing multiple epitopes. Protein binding assays showed that metal binding to the NH2-terminal extension had effects on the interaction of TnT with troponin I, troponin C, and most significantly, tropomyosin. The data indicate that the NH2-terminal Tx [4–7 repeats of a sequence motif His-(Glu/Ala)-Glu-Ala-His] extension confers a specific conformational modulation in the slow skeletal muscle TnT.

Genomic structure of the chicken slow skeletal muscle troponin T gene

Gene ◽  
2004 ◽  
Vol 338 (2) ◽  
pp. 243-256 ◽  
Author(s):  
Chinami Hirao ◽  
Izuru Yonemura ◽  
Jun-Ichi Miyazaki
Keyword(s):  
Skeletal Muscle ◽  
Troponin T ◽  
Genomic Structure ◽  
Slow Skeletal Muscle

Effects of exercise on plasma myosin heavy chain fragments and MRI of skeletal muscle

1992 ◽  
Vol 72 (2) ◽  
pp. 656-663 ◽  
Author(s):  
J. Mair ◽  
A. Koller ◽  
E. Artner-Dworzak ◽  
C. Haid ◽  
K. Wicke ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Plasma Concentrations ◽  
Eccentric Contractions ◽  
Cardiac Troponin T ◽  
Skeletal Muscle Myosin ◽  
Slow Skeletal Muscle ◽  
Slow Twitch ◽  
Muscle Myosin

The effects of a single series of high-force eccentric contractions involving the quadriceps muscle group (single leg) on plasma concentrations of muscle proteins were examined as a function of time, in the context of measurements of torque production and magnetic resonance imaging (MRI) of the involved muscle groups. Plasma concentrations of slow-twitch skeletal (cardiac beta-type) myosin heavy chain (MHC) fragments, myoglobin, creatine kinase (CK), and cardiac troponin T were measured in blood samples of six healthy male volunteers before and 2 h after 70 eccentric contractions of the quadriceps femoris muscle. Screenings were conducted 1, 2, 3, 6, 9, and 13 days later. To visualize muscle injury, MRI of the loaded and unloaded thighs was performed 3, 6, and 9 days after the eccentric exercise bout. Force generation of the knee extensors was monitored on a dynamometer (Cybex II+) parallel to blood sampling. Exercise resulted in a biphasic myoglobin release profile, delayed CK and MHC peaks. Increased MHC fragment concentrations of slow skeletal muscle myosin occurred in late samples of all participants, which indicated a degradation of slow skeletal muscle myosin. Because cardiac troponin T was within the normal range in all samples, which excluded a protein release from the heart (cardiac beta-type MHC), this finding provides evidence for an injury of slow-twitch skeletal muscle fibers in response to eccentric contractions. Muscle action revealed delayed reversible increases in MRI signal intensities on T2-weighted images of the loaded vastus intermedius and deep parts of the vastus lateralis. We attributed MRI signal changes due to edema in part to slow skeletal muscle fiber injury.(ABSTRACT TRUNCATED AT 250 WORDS)

Genomic sequence and structural organization of mouse slow skeletal muscle troponin T gene

Gene ◽  
1999 ◽  
Vol 229 (1-2) ◽  
pp. 1-10 ◽  
Author(s):  
Qi-Quan Huang ◽  
Aihua Chen ◽  
Jian-Ping Jin
Keyword(s):  
Skeletal Muscle ◽  
Structural Organization ◽  
Genomic Sequence ◽  
Troponin T ◽  
Slow Skeletal Muscle

scholarly journals Effect of a Unique Polymophism in Tropomyosin-Binding Site 1 of Toad Slow Skeletal Muscle Troponin T on Cardiac Function

2018 ◽  
Vol 114 (3) ◽  
pp. 138a-139a
Author(s):  
Hanzhong Feng ◽  
Shirin Akhter ◽  
Hui Wang ◽  
Jian-Ping Jin
Keyword(s):  
Skeletal Muscle ◽  
Cardiac Function ◽  
Binding Site ◽  
Troponin T ◽  
Slow Skeletal Muscle

scholarly journals Biophysical and Biochemical Studies of Human Slow Skeletal Troponin T Isoforms in Slow Skeletal Muscle

2010 ◽  
Vol 98 (3) ◽  
pp. 352a
Author(s):  
Michelle A. Jones ◽  
José R. Pinto ◽  
Qian Xu ◽  
Aldrin V. Gomes ◽  
Michelle S. Parvatiyar ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Troponin T ◽  
Slow Skeletal Muscle ◽  
Biochemical Studies
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