scholarly journals The role of discharge history effects in rapid adaptation of auditory‐nerve fibers

1986 ◽  
Vol 79 (S1) ◽  
pp. S33-S33
Author(s):  
Bernd Lutkenhoner ◽  
Robert L. Smith
Keyword(s):  
Auditory Nerve ◽  
Nerve Fibers ◽  
Rapid Adaptation ◽  
History Effects ◽  
Auditory Nerve Fibers

scholarly journals Probing adaptation and spontaneous firing in human auditory-nerve fibers with far-field peri-stimulus time responses

2021 ◽  
Author(s):  
Antoine Huet ◽  
Charlène Batrel ◽  
Xavier Dubernard ◽  
Jean-Charles Kleiber ◽  
Gilles Desmadryl ◽  
...  
Keyword(s):  
Auditory Nerve ◽  
Round Window ◽  
Nerve Fibers ◽  
Electrical Signal ◽  
Cochlear Nerve ◽  
Spontaneous Discharge ◽  
Rapid Adaptation ◽  
Discharge Rates ◽  
Auditory Nerve Fibers ◽  
Stimulus Time

AbstractInformation in sound stimuli is conveyed from sensory hair cells to the cochlear nuclei by the firing of auditory nerve fibers (ANFs). For obvious ethical reasons, single unit recordings from the cochlear nerve have never been performed in human, thus functional hallmarks of ANFs are unknown. By filtering and rectifying the electrical signal recorded at the round window of gerbil cochleae, we reconstructed a peri-stimulus time response (PSTR), with a waveform similar to the peri-stimulus time histograms (PSTHs) recorded from single ANFs. Pair-by-pair analysis of simultaneous PSTR and PSTH recordings in gerbil provided a model to predict the rapid adaptation and spontaneous discharge rates (SR) in a population of ANFs according to their location in the cochlea. We then probed the model in the mouse, in which the SR-based distribution of ANFs differs from the gerbil. We show that the PSTR-based predictions of the rapid adaptation time constant and mean SR across frequency again matched those obtained by recordings from single ANFs. Using PSTR recorded from the human cochlear nerve in 8 normal-hearing patients who underwent cerebellopontine angle surgeries for a functional cranial-nerve disorders (trigeminal neuralgia or hemifacial spasm), we predicted a rapid adaptation of about 3 milliseconds and a mean SR of 23 spikes/s in the 4 kHz frequency range in human ANFs. Together, our results support the use of PSTR as a promising diagnostic tool to map the auditory nerve in humans, thus opening new avenues to better understanding neuropathies, tinnitus, and hyperacusis.

Responses of auditory‐nerve fibers to multiple‐tone complexes

1987 ◽  
Vol 82 (6) ◽  
pp. 1989-2000 ◽  
Author(s):  
Li Deng ◽  
C. Daniel Geisler ◽  
Steven Greenberg
Keyword(s):  
Auditory Nerve ◽  
Nerve Fibers ◽  
Auditory Nerve Fibers

Responses of Single Auditory‐Nerve Fibers in Cochleas Damaged by Ototoxic Drugs

1969 ◽  
Vol 46 (1A) ◽  
pp. 106-107
Author(s):  
R. A. Levine ◽  
E. C. Moxon ◽  
N. Y. S. Kiang
Keyword(s):  
Auditory Nerve ◽  
Nerve Fibers ◽  
Ototoxic Drugs ◽  
Auditory Nerve Fibers
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