Pharmacological Characterization of a New, Orally Active and Potent Allosteric Metabotropic Glutamate Receptor 1 Antagonist, 4-[1-(2-Fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC)

Metabotropic Glutamate ◽

Metabotropic Glutamate Receptor 1 ◽

ChemInform Abstract: Design, Synthesis, and Pharmacological Characterization of (+)-2- Aminobicyclo(3.1.0)hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvul

ChemInform ◽

10.1002/chin.199722076 ◽

2010 ◽

Vol 28 (22) ◽

pp. no-no

Author(s):

J. A. MONN ◽

M. J. VALLI ◽

S. M. MASSEY ◽

R. A. WRIGHT ◽

C. R. SALHOFF ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Design Synthesis ◽

Metabotropic Glutamate ◽

Group 2 ◽

Glutamate Receptor Agonist ◽

Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

Journal of Medicinal Chemistry ◽

10.1021/jm9606756 ◽

1997 ◽

Vol 40 (4) ◽

pp. 528-537 ◽

Cited By ~ 299

Author(s):

James A. Monn ◽

Matthew J. Valli ◽

Steven M. Massey ◽

Rebecca A. Wright ◽

Craig R. Salhoff ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Design Synthesis ◽

Metabotropic Glutamate ◽

Group 2 ◽

Glutamate Receptor Agonist ◽

Synthesis, SARs, and Pharmacological Characterization of 2-Amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent, Selective, and Orally Active Group II Metabotropic Glutamate Receptor Agonists

Journal of Medicinal Chemistry ◽

10.1021/jm000346k ◽

2000 ◽

Vol 43 (25) ◽

pp. 4893-4909 ◽

Cited By ~ 94

Author(s):

Atsuro Nakazato ◽

Toshihito Kumagai ◽

Kazunari Sakagami ◽

Ryoko Yoshikawa ◽

Yoshiko Suzuki ◽

...

Keyword(s):

Dicarboxylic Acid ◽

Glutamate Receptor ◽

Active Group ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonists ◽

Identification of single nucleotide polymorphisms of the human metabotropic glutamate receptor 1 gene and pharmacological characterization of a P993S variant

Biochemical Pharmacology ◽

10.1016/j.bcp.2008.12.003 ◽

2009 ◽

Vol 77 (7) ◽

pp. 1246-1253 ◽

Cited By ~ 3

Author(s):

Patrick M. Downey ◽

Roberta Petrò ◽

Jason S. Simon ◽

David Devlin ◽

Gianluca Lozza ◽

...

Keyword(s):

Single Nucleotide Polymorphisms ◽

Glutamate Receptor ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Metabotropic Glutamate ◽

Metabotropic Glutamate Receptor 1

In Vitro Pharmacological Characterization of Novel Isoxazolopyridone Derivatives as Allosteric Metabotropic Glutamate Receptor 7 Antagonists

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.107.124701 ◽

2007 ◽

Vol 323 (1) ◽

pp. 147-156 ◽

Cited By ~ 96

Author(s):

Gentaroh Suzuki ◽

Naohiro Tsukamoto ◽

Hiroshi Fushiki ◽

Aki Kawagishi ◽

Masayuki Nakamura ◽

...

Keyword(s):

Glutamate Receptor ◽

Molecular Cloning, Functional Expression and Pharmacological Characterization of the Human Metabotropic Glutamate Receptor Type 2

European Journal of Neuroscience ◽

10.1111/j.1460-9568.1995.tb00666.x ◽

1995 ◽

Vol 7 (4) ◽

pp. 622-629 ◽

Cited By ~ 49

Author(s):

P. J. Flor ◽

K. Lindauer ◽

I. Püttner ◽

D. Rüegg ◽

S. Lukic ◽

...

Keyword(s):

Molecular Cloning ◽

Glutamate Receptor ◽

Functional Expression ◽

Receptor Type ◽

Synthesis and Pharmacological Characterization of Aminocyclopentanetricarboxylic Acids: New Tools to Discriminate between Metabotropic Glutamate Receptor Subtypes

Journal of Medicinal Chemistry ◽

10.1021/jm970207b ◽

1997 ◽

Vol 40 (19) ◽

pp. 3119-3129 ◽

Cited By ~ 106

Author(s):

Francine C. Acher ◽

Frédérique J. Tellier ◽

Robert Azerad ◽

Isabelle N. Brabet ◽

Laurent Fagni ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Subtypes ◽

Pharmacological characterization of the rat metabotropic glutamate receptor type 8a revealed strong similarities and slight differences with the type 4a receptor

European Journal of Pharmacology ◽

10.1016/s0014-2999(00)00113-8 ◽

2000 ◽

Vol 394 (1) ◽

pp. 17-26 ◽

Cited By ~ 23

Author(s):

Cyril De Colle ◽

Anne-Sophie Bessis ◽

Joël Bockaert ◽

Francine Acher ◽

Jean-Philippe Pin

Keyword(s):

Glutamate Receptor ◽

Receptor Type ◽

Expression and pharmacological characterization of mouse metabotropic glutamate receptor subtype 5b

The FASEB Journal ◽

10.1096/fasebj.21.6.a790 ◽

2007 ◽

Vol 21 (6) ◽

Author(s):

Brian G. Salisbury ◽

Gitali Mukhopadhyay ◽

Ellie Norris ◽

Thomas M. Laz

Keyword(s):

Glutamate Receptor ◽

Receptor Subtype ◽

A pharmacological characterization of the mGluR1α subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line

Brain Research ◽

10.1016/0006-8993(93)91592-g ◽

1993 ◽

Vol 619 (1-2) ◽

pp. 22-28 ◽

Cited By ~ 71

Author(s):

Christian Thomsen ◽

Eileen R. Mulvihill ◽

Betty Haldeman ◽

Darryl S. Pickering ◽

David R. Hampson ◽

...

Keyword(s):

Cell Line ◽

Glutamate Receptor ◽

Kidney Cell ◽

Baby Hamster Kidney Cell ◽

Baby Hamster Kidney ◽

Kidney Cell Line ◽