Identification and Characterization of NDT 9513727 [N,N-bis(1,3-Benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a Novel, Orally Bioavailable C5a Receptor Inverse Agonist

2008 ◽  
Vol 327 (3) ◽  
pp. 898-909 ◽  
Author(s):  
Robbin M. Brodbeck ◽  
Daniel N. Cortright ◽  
Andrzej P. Kieltyka ◽  
Jianying Yu ◽  
Carolyn O. Baltazar ◽  
...  
Keyword(s):  
Inverse Agonist ◽  
C5a Receptor ◽  
Orally Bioavailable ◽  
Identification And Characterization ◽  
Receptor Inverse Agonist

scholarly journals Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate

2014 ◽  
Vol 5 (5) ◽  
pp. 474-479 ◽  
Author(s):  
Samit K. Bhattacharya ◽  
Kim Andrews ◽  
Ramsay Beveridge ◽  
Kimberly O. Cameron ◽  
Chiliu Chen ◽  
...  
Keyword(s):  
Inverse Agonist ◽  
Ghrelin Receptor ◽  
Orally Bioavailable ◽  
Receptor Inverse Agonist ◽  
Clinical Candidate

Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents

2008 ◽  
Vol 579 (1-3) ◽  
pp. 215-224 ◽  
Author(s):  
Lauren P. Shearman ◽  
D. Sloan Stribling ◽  
Ramon E. Camacho ◽  
Kimberly M. Rosko ◽  
Junying Wang ◽  
...  
Keyword(s):  
Inverse Agonist ◽  
Cb1 Receptor ◽  
Cannabinoid Cb1 Receptor ◽  
Receptor Inverse Agonist

Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity

2011 ◽  
Vol 384 (6) ◽  
pp. 565-581 ◽  
Author(s):  
Laura H. Jacobson ◽  
S. Renee Commerford ◽  
Sarah P. Gerber ◽  
Yu Alice Chen ◽  
Beatriz Dardik ◽  
...  
Keyword(s):  
Metabolic Profile ◽  
Inverse Agonist ◽  
Cb1 Receptor ◽  
Central Activity ◽  
Receptor Inverse Agonist
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