Competitive dynamics underlie cognitive improvements during sleep

We provide evidence that human sleep is a competitive arena in which cognitive domains vie for limited resources. Using pharmacology and effective connectivity analysis, we demonstrate that long-term memory and working memory are served by distinct offline neural mechanisms that are mutually antagonistic. Specifically, we administered zolpidem to increase central sigma activity and demonstrated targeted suppression of autonomic vagal activity. With effective connectivity, we determined the central activity has greater causal influence over autonomic activity, and the magnitude of this influence during sleep produced a behavioral trade-off between offline long-term and working memory processing. These findings suggest a sleep switch mechanism that toggles between central sigma-dependent long-term memory and autonomic vagal-dependent working memory processing.

Preferences and constraints on an Islamic consumer: An analysis from Islamic perspective

Consumption is one of the central activity of an economy. It is perhaps the ultimate aim of all economic activity. The paper investigates Muslim consumer behaviour. The question that this study answers are what Muslim consumer behaviour is and how does it differ from Nep-Classical approach. This Study has adopted a realist ontological stance and interpretivist Epistemology. Units of data collection for the study were the Quranic verses and the texts of Hadith. The study found that an optimal Muslim consumer is confined in his consumption and spending to the boundaries of Sharia i.e., to stay away from Tabzir (pre-eminence) and Israf (extravagance) and follows the balanced approach, which is moderation and unlike modern day neo-classical Consumer theory, consumption is not the ultimate aim of human being. The paper suggests that the consumption behaviour of Muslim consumer must be guided by Islamic Principles. The paper also finds that the Muslim consumer should prioritize his/her expenditure within the domain of the Halal earning and spending. Thus, the findings of the paper show a compact Islamic consumer framework.

The Research on the Product Humanization Model Based on the Evolution of Consumer Purchase Pat

Digital economy gives new connotation to business model. In the process of business model changing from vertical to horizontal, from exclusive to inclusive, and from individual to social, the central activity of enterprise marketing should be transferred to how to actively interact with consumers, so that consumers can more participate in the process of enterprise marketing value creation. This paper focuses on the model of consumers’ participation in marketing value creation. Firstly, this paper studies the basic model of consumer purchase path evolution, and proposes 5A +1D model based on the basic model. Then, based on the 5A+1D model, an important carrier for consumers to participate in the value creation of marketing is proposed: the product humanization model. Secondly, the paper analyzes the ideal migration mode of consumer purchase path under humanistic products: “W” model, which finally reaches the balance at both ends of 5A+1D model. Under the ecological background of open innovation, this paper extends the chain of consumers’ purchase path and realizes the co-creation of consumers and enterprises’ value, and designs a human-oriented product model based on the chain of consumers’ extended purchase path. The W model achieves the balance between the beginning and the end of the consumer purchase path model, which provides a theoretical basis for the intervention points of enterprises on the overall consumers’ purchase path.

Pelatihan Pembuatan Video Pembelajaran Online Bagi Mahasiswa Calon Guru Pendidikan Agama Islam Sebagai Antisipasi Mewabahnya Covid 19 Sekolah Tinggi Ilmu Tarbiyah Syamsul Ma’arif Bontang Tahun 2020/2021

Education is a central activity in advancing and developing the potential of students, which in this case are prospective students of Islamic religious education teachers at the Bontang Tarbiyah College of Sciences. With the outbreak of covid-19, educational activities have changed very significantly related to the implementation of learning activities from face to face to online learning. With these changes, it automatically forces education providers from basic to high levels to be able and creative in developing the online learning system. So that the results of online learning can be achieved properly, it is necessary to carry out training activities not only making learning videos but more importantly how a lecturer or teacher or student as a prospective teacher is able to use internet equipment such as using computers, using online learning tools, making online learning tools and the preparation of online learning materials and the process of implementing online learning. All of this is expected to produce the quality of education as expected.

Design of carbon supports for metal-catalyzed acetylene hydrochlorination

For decades, carbons have been the support of choice in acetylene hydrochlorination, a key industrial process for polyvinyl chloride manufacture. However, no unequivocal design criteria could be established to date, due to the complex interplay between the carbon host and the metal nanostructure. Herein, we disentangle the roles of carbon in determining activity and stability of platinum-, ruthenium-, and gold-based hydrochlorination catalysts and derive descriptors for optimal host design, by systematically varying the porous properties and surface functionalization of carbon, while preserving the active metal sites. The acetylene adsorption capacity is identified as central activity descriptor, while the density of acidic oxygen sites determines the coking tendency and thus catalyst stability. With this understanding, a platinum single-atom catalyst is developed with stable catalytic performance under two-fold accelerated deactivation conditions compared to the state-of-the-art system, marking a step ahead towards sustainable PVC production.

Pemberdayaan Masyarakat melalui Perpustakaan Desa Berbasis Inklusi Sosial (Studi Kasus Perpustakaan “Sumber Ilmu” Desa Marga Sakti Kabupaten Musirawas)

Libraries can play a more role and can contribute in terms of community empowerment, closer, invite and empower the community. One way to get closer to the community is that the library can use the concept of inclusion to achieve its goals as a principle of lifelong learning. Inclusion-based libraries are libraries that facilitate the community in developing their potential by seeing cultural diversity, willingness to accept change, and offering opportunities to try, protect and fight for culture and human rights. This has been done by the Library of Science Resources in Marga Sakti Village, Musi Rawas Regency, with the concept of a Village Library Based on Social Inclusion, which has made the library an institution that can empower the community through productive activities such as making bitter melon chips, cultivating crickets, providing internet access for the community, Karang Taruna activities by establishing Youth Bands, PKK activities centered in libraries, storytelling activities, mobile libraries, establishing reading villages and others. Of the many activities above, this indicates that the library has become the central activity of the village community and as a concrete manifestation that the Marga Sakti Village Resource Library has implemented the concept of Social Inclusion.

Pitolisant in an Adolescent with Prader-Willi Syndrome

This case report evaluates the potential benefit of pitolisant in a 15-year-old female with Prader-Willi syndrome, obsessive-compulsive disorder, autism spectrum disorder, and mild intellectual disability. Due to its action on the H3 receptor, it enhances central activity of histaminergic neurons resulting in increased alertness, irrespective of the loss of orexin neurons seen in narcolepsy. Additionally, it is thought to modulate various other neurotransmitter systems including acetylcholine, norepinephrine, and dopamine. Pitolisant has the potential to improve many symptoms in patients with Prader-Willi syndrome and it appears to be well tolerated with minimal side effects observed. Therefore, the use of pitolisant should be considered in patients with Prader-Willi syndrome who fail a psychostimulant trial.

Epistemic injustice in workplace hierarchies: Power, knowledge and status

Contemporary workplaces are mostly hierarchical. Intrinsic and extrinsic bads of workplace hierarchies have been widely discussed in the literature on workplace democracy and workplace republicanism. However, a distinctively intrinsic relational bad, epistemic injustice in the workplace, has largely been neglected by both normative theorists of the workplace and theorists of epistemic injustice. This article, by bringing in the insights of Miranda Fricker’s influential conceptualization of epistemic injustice, argues that hierarchical workplaces have contributed to and reinforced both testimonial and hermeneutical injustices in a central activity of most people’s daily lives. This article argues that these injustices are moral wrongs and thus moral injury to the workers. The article concludes by demonstrating that traditional hierarchy is the most epistemically unjust form of hierarchy, while contestatory hierarchy, because of its emphasis on granting the right to the workers to be listened, is less unjust epistemically.

Is “Leptin Resistance” Another Key Resistance to Manage Type 2 Diabetes?

Although novel pharmacological options for the treatment of type 2 diabetes mellitus (DM2) have been observed to modulate the functionality of several key organs in glucose homeostasis, successful regulation of insulin resistance (IR), body weight management, and pharmacological treatment of obesity remain notable problems in endocrinology. Leptin may be a pivotal player in this scenario, as an adipokine which centrally regulates appetite and energy balance. In obesity, excessive caloric intake promotes a low-grade inflammatory response, which leads to dysregulations in lipid storage and adipokine secretion. In turn, these entail alterations in leptin sensitivity, leptin transport across the blood-brain barrier and defects in post-receptor signaling. Furthermore, hypothalamic inflammation and endoplasmic reticulum stress may increase the expression of molecules which may disrupt leptin signaling. Abundant evidence has linked obesity and leptin resistance, which may precede or occur simultaneously to IR and DM2. Thus, leptin sensitivity may be a potential early therapeutic target that demands further preclinical and clinical research. Modulators of insulin sensitivity have been tested in animal models and small clinical trials with promising results, especially in combination with agents such as amylin and GLP-1 analogs, in particular, due to their central activity in the hypothalamus.

4. That Which Is Worthy of Love: A Philosophical Framework for Reflection on Staff-Student Partnerships for the Future University

<?page nr="71"?>Abstract In this article we develop a philosophical understanding of student-staff partnership through a novel interpretation and development of Aristotle’s friendship arguments. In contributing to an emerging critical field of study of student-staff partnership, we begin by explaining the current state of being a student in the neoliberal university. In light of the polylithic changes neo-liberalism impresses on student being and becoming, and how partnerships are proposed paradoxically as both a counterculture and serving this agenda, we develop a typology of partnership that helps those working in, and proposing to work in partnership, to discuss their ethical basis. For Aristotle, “What is worthy of love?” in the relationship, is a salient question. Is it utility? Is it pleasure? Is it virtue and flourishing? In the typology we propose an additional form of partnership—where creativity is a central activity worthy of time, energy, and love. It is reasonable to suggest that student-staff partnerships are likely to remain, if not grow, in the future university, and are likely to have a significant impact on the being and becoming of the student. It is for this reason we develop the typology in order for participants, particularly students, to have clarity in understanding the ethical motivation and purpose of the partnership in the university. We see this clarity as enabling students to see how the partnership will contribute to their notion of the flourishing life.