Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

Science ◽

10.1126/science.1168750 ◽

2009 ◽

Vol 323 (5922) ◽

pp. 1718-1722 ◽

Cited By ~ 1340

Author(s):

S. G. Aller ◽

J. Yu ◽

A. Ward ◽

Y. Weng ◽

S. Chittaboina ◽

...

Keyword(s):

Molecular Basis ◽

Drug Binding ◽

Specific Drug ◽

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Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

Biophysical Journal ◽

10.1016/j.bpj.2009.12.4143 ◽

2010 ◽

Vol 98 (3) ◽

pp. 755a

Author(s):

Stephen G. Aller

Keyword(s):

Molecular Basis ◽

Drug Binding ◽

Specific Drug ◽

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Faculty Opinions recommendation of Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1158560.793502871 ◽

2015 ◽

Author(s):

Stephan Wilkens

Keyword(s):

Molecular Basis ◽

Drug Binding ◽

Specific Drug ◽

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Faculty Opinions recommendation of Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1158560.618749 ◽

2009 ◽

Author(s):

Victor Ling

Keyword(s):

Molecular Basis ◽

Drug Binding ◽

Specific Drug ◽

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Faculty Opinions recommendation of Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1158560.619202 ◽

2009 ◽

Author(s):

Bruno Stieger

Keyword(s):

Molecular Basis ◽

Drug Binding ◽

Specific Drug ◽

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Faculty Opinions recommendation of Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1158560.619081 ◽

2009 ◽

Author(s):

Paul Roepe

Keyword(s):

Molecular Basis ◽

Drug Binding ◽

Specific Drug ◽

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The flexibility of P-glycoprotein for its poly-specific drug binding from molecular dynamics simulations

Journal of Biomolecular Structure and Dynamics ◽

10.1080/07391102.2012.706079 ◽

2013 ◽

Vol 31 (6) ◽

pp. 612-629 ◽

Author(s):

Ming Liu ◽

Tingjun Hou ◽

Zhiwei Feng ◽

Youyong Li

Keyword(s):

Molecular Dynamics ◽

Molecular Dynamics Simulations ◽

Drug Binding ◽

Specific Drug ◽

P Glycoprotein ◽

Dynamics Simulations

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Specific drug binding by purified lipid-reconstituted P-glycoprotein: Dependence on the lipid composition

Biochimica et Biophysica Acta (BBA) - Biomembranes ◽

10.1016/0005-2736(92)90334-i ◽

1992 ◽

Vol 1107 (1) ◽

pp. 105-110 ◽

Author(s):

Tohru Saeki ◽

Alfredo M. Shimabuku ◽

Kazumitsu Ueda ◽

Tohru Komano

Keyword(s):

Lipid Composition ◽

Drug Binding ◽

Specific Drug ◽

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Drug-Binding to Distinct Sites of the Multidrug Exporter P-Glycoprotein

Biophysical Journal ◽

10.1016/j.bpj.2020.11.645 ◽

2021 ◽

Vol 120 (3) ◽

pp. 69a-70a

Author(s):

Ina Urbatsch ◽

Anthony A. Bui ◽

Joel Zapata ◽

Douglas J. Swartz ◽

Courtney Katz ◽

...

Keyword(s):

Drug Binding ◽

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Molecular basis of multidrug resistance mediated by P-glycoprotein

Current Opinion in Biotechnology ◽

10.1016/0958-1669(91)90021-v ◽

1991 ◽

Vol 2 (2) ◽

pp. 278-281 ◽

Author(s):

Christopher F. Higgins

Keyword(s):

Multidrug Resistance ◽

Molecular Basis ◽

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Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.022049799 ◽

2002 ◽

Vol 99 (6) ◽

pp. 3511-3516 ◽

Author(s):

Tip W. Loo ◽

David M. Clarke

Keyword(s):

Multidrug Resistance ◽

Binding Site ◽

Binding Sites ◽

Drug Binding ◽

Atp Binding ◽

Drug Binding Site ◽

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