scholarly journals Inhibitory effects of acyclic nucleoside phosphonate analogs, including (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, on Epstein-Barr virus replication.

1991 ◽  
Vol 35 (11) ◽  
pp. 2440-2443 ◽  
Author(s):  
J C Lin ◽  
E De Clercq ◽  
J S Pagano
Keyword(s):  
Virus Replication ◽  
Epstein Barr Virus ◽  
Inhibitory Effects ◽  
Barr Virus ◽  
Acyclic Nucleoside ◽  
Epstein Barr ◽  
Acyclic Nucleoside Phosphonate

scholarly journals Inhibitory Effects of Novel Nucleoside and Nucleotide Analogues on Epstein—Barr Virus Replication

1998 ◽  
Vol 9 (3) ◽  
pp. 275-282 ◽  
Author(s):  
A Meerbach ◽  
A Holý ◽  
P Wutzler ◽  
E De Clercq ◽  
J Neyts
Keyword(s):  
Dna Hybridization ◽  
Epstein Barr Virus ◽  
Inhibitory Effects ◽  
Nucleotide Analogues ◽  
Barr Virus ◽  
Ebv Dna ◽  
Acyclic Nucleoside ◽  
Epstein Barr ◽  
New Compounds ◽  
Acyclic Nucleoside Phosphonate

The anti-Epstein–Barr virus (EBV) activity of different classes of compounds was assessed by means of an EBV DNA hybridization assay using a digoxigenin-labelled probe specific for the BamHI W fragment of the EBV genome, as well as by measuring viral capsid antigen (VCA) expression after a 7 day incubation period of P3HR-1 producer cells with the test substances. Acyclovir, ganciclovir, cidofovir and zidovudine were included as reference compounds. Several compounds proved to be potent and selective inhibitors of EBV DNA synthesis and VCA expression. Of the new compounds that were evaluated for their anti-EBV activity, the highest efficacy (lowest EC50) and highest selectivity index (SI) were shown by the purine nucleoside analogue 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine (S2242) (EC50 0.6 ng/ml; SI 600), the acyclic nucleoside phosphonate analogues 9-(2-phosphonomethoxyethyl)-6-dimethylaminopurine (EC50 1.1 μg/ml; SI 91), 9-(2-phosphonomethoxyethyl)-2-amino-6-benzhydrylaminopurine (EC501.3 μg/ml; SI 29), 7-(2-phosphonomethoxyethyl)-6-dimethylaminopurine (EC50 0.8 μg/ml; SI 56), 9-( R)-(2-phosphonomethoxypropyl)-6-(2-dimethylaminoethyl)-aminopurine (EC50 0.5 μg/ml; SI 42), the 2′,3′-dideoxythymidine derivative 3′-oximino-2′,3′-dideoxythymidine (EC501.5 μg/ml; SI 65), and 1-(2,3-dideoxy-3- N-hydroxyamino-β-d-threo-pentafuran yl)pentafuranosyl)thymine (EC50 4.1 μg/ml; SI >24).

Latent and lytic Epstein-Barr virus replication strategies

2004 ◽  
Vol 15 (1) ◽  
pp. 3-15 ◽  
Author(s):  
Tatsuya Tsurumi ◽  
Masatoshi Fujita ◽  
Ayumi Kudoh
Keyword(s):  
Virus Replication ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

Inhibitory effects of 3-nitrophloroglucinecarboxylic acid derivatives on Epstein-Barr virus early antigen induction

1993 ◽  
Vol 68 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Ichiro Honda ◽  
Harukuni Tokuda ◽  
Mutsuo Kozuka ◽  
Koichi Yoneyama ◽  
Hoyoku Nishino ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Inhibitory Effects ◽  
Early Antigen ◽  
Barr Virus ◽  
Epstein Barr

Lucidenic Acids P and Q, Methyl Lucidenate P, and Other Triterpenoids from the FungusGanoderma lucidumand Their Inhibitory Effects on Epstein−Barr Virus Activation

2003 ◽  
Vol 66 (12) ◽  
pp. 1582-1585 ◽  
Author(s):  
Kenji Iwatsuki ◽  
Toshihiro Akihisa ◽  
Harukuni Tokuda ◽  
Motohiko Ukiya ◽  
Manabu Oshikubo ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Inhibitory Effects ◽  
Barr Virus ◽  
Epstein Barr

Studies on Inhibitors of Skin Tumor Promotion, III. Inhibitory Effects of Isoflavonoids from Wisteria brachybotrys on Epstein-Barr Virus Activation

1988 ◽  
Vol 51 (6) ◽  
pp. 1266-1270 ◽  
Author(s):  
Takao Konoshima ◽  
Emiko Okamoto ◽  
Mutsuo Kozuka ◽  
Hoyoku Nishino ◽  
Harukuni Tokuda ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Tumor Promotion ◽  
Skin Tumor ◽  
Inhibitory Effects ◽  
Barr Virus ◽  
Epstein Barr

New abietane diterpenoids from the cones of Larix kaempferi

2000 ◽  
Vol 78 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Hironori Ohtsu ◽  
Reiko Tanaka ◽  
Yasuko In ◽  
Shunyo Matsunaga ◽  
Harukuni Tokuda ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Tumor Promoter ◽  
Larix Kaempferi ◽  
Inhibitory Effects ◽  
Early Antigen ◽  
Barr Virus ◽  
Primary Screening ◽  
Abietane Diterpenoids ◽  
Epstein Barr ◽  
Abietane Diterpenes

A new podocarpane diterpene, 7α,15-dihydroxypodocarp-8(14)-en-13-one (1) and eight new abietane diterpenes, abiet-8(14)-en-7α,13β,15,18-tetraol (2), 7α,13β,15-trihydroxyabiet-8(14)-en-18-oic acid (3), 13β,18-dihydroxyabiet-8(14)-en-7-one (4), 13β,15,18-trihydroxyabiet-8(14)-en-7-one (5), 7-oxo-13β-methoxyabiet-8(14)- en-18-oic acid (7), abiet-8(14)-en-7α,12α,13β,18-tetraol (8), 7α,12α,13β-trihydroxyabiet-8(14)-en-18-oic acid (9), and abiet-8(14)-en-7α,12α,13β,15,18-pentaol (10) were isolated from the CHCl3 extract of the cones of Larix kaempferi. Their structures were determined on the basis of chemical and spectral evidence. The inhibitory effects of compounds 1-4 and 7-9 on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), were examined for a primary screening for anti-tumor promotors. Key words: Larix kaempferi, Pinaceae, cones, abietane, EBV-EA.

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