scholarly journals Physical Factors That Affect In Vitro Autographa californica Nuclear Polyhedrosis Virus Infection

1981 ◽  
Vol 41 (5) ◽  
pp. 1166-1172 ◽  
Author(s):  
Edward M. Dougherty ◽  
Ronald M. Weiner ◽  
James L. Vaughn ◽  
Charles F. Reichelderfer
Keyword(s):  
Virus Infection ◽  
Nuclear Polyhedrosis Virus ◽  
Autographa Californica ◽  
Physical Factors ◽  
Polyhedrosis Virus ◽  
Nuclear Polyhedrosis

scholarly journals Induction of Antitumor Acquired Immunity by Baculovirus Autographa californica Multiple Nuclear Polyhedrosis Virus Infection in Mice

2007 ◽  
Vol 15 (2) ◽  
pp. 376-378 ◽  
Author(s):  
Masayuki Kitajima ◽  
Hiroshi Takaku
Keyword(s):  
Gene Therapy ◽  
Virus Infection ◽  
Nuclear Polyhedrosis Virus ◽  
Tumor Therapy ◽  
Autographa Californica ◽  
Acquired Immunity ◽  
Gene Therapy Vector ◽  
Polyhedrosis Virus ◽  
Nuclear Polyhedrosis

ABSTRACT The baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) has been studied as a gene therapy vector. Here, we demonstrated that AcMNPV induces antitumor acquired immunity. These results suggest that AcMNPV has the potential to be an efficient virus or tumor therapy agent which induces innate and acquired immunity.

scholarly journals The Effect of a Small Conotoxin-Like ctx Gene from Autographa californica Nuclear Polyhedrosis Virus (AcMNPV) on Insect Hemolymph Melanization

2012 ◽  
Vol 61 (3) ◽  
pp. 183-189 ◽  
Author(s):  
QING CAO ◽  
SHAN$YING ZHU ◽  
YAN WU ◽  
YONG LIU ◽  
JIANG ZHU ◽  
...  
Keyword(s):  
Nuclear Polyhedrosis Virus ◽  
Fusion Gene ◽  
Autographa Californica ◽  
Insect Larvae ◽  
Cysteine Motif ◽  
Bmnpv Bacmid ◽  
Polyhedrosis Virus ◽  
Nuclear Polyhedrosis

The conotoxin-like (ctx) gene encodes a small cysteine-rich polypeptide in various baculoviruses. Previous research has demonstrated that the product of the ctx gene could be purified from insect cells infected by Autographa californica nuclear polyhedrosis virus (AcMNPV), but its function was unknown. In this paper, we compared the conserved cysteine motif structure (CX3GX2CX5CCX3CX6C) of the ctx gene in baculoviruses and generated recombinant Bombyx mori nuclear polyhedrosis virus (BmNPV) with the BmNPV bacmid system. The recombinant BmNPV contained the ctx gene from AcMNPV or a fusion gene of ctx with eGFP, respectively. Fluorescence in CTX-eGFP-positive cells was mainly observed on the cell membrane. To gain insight into CTX function, two methods were used to elucidate the affect CTX had on hemolymph melanization in vivo and in vitro in insect larvae and pupae. The results indicated that CTX abrogates hemolymph melanization; however, the mechanisms require further evaluation.

Autographa californica Nuclear Polyhedrosis Virus Structural Proteins Compared from in vivo and in vitro Sources

Intervirology ◽  
1979 ◽  
Vol 11 (2) ◽  
pp. 82-88 ◽  
Author(s):  
James E. Maruniak ◽  
Max D. Summers ◽  
Louis A. Falcon ◽  
Gale E. Smith
Keyword(s):  
Nuclear Polyhedrosis Virus ◽  
Autographa Californica ◽  
Structural Proteins ◽  
Polyhedrosis Virus ◽  
Nuclear Polyhedrosis
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