scholarly journals Protection against lethal challenge of BALB/c mice by passive transfer of monoclonal antibodies to five glycoproteins of herpes simplex virus type 2.

1982 ◽  
Vol 37 (3) ◽  
pp. 1132-1137 ◽  
Author(s):  
N Balachandran ◽  
S Bacchetti ◽  
W E Rawls
Keyword(s):  
Monoclonal Antibodies ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Passive Transfer ◽  
Lethal Challenge ◽  
Simplex Virus

scholarly journals Monoclonal antibodies to two glycoproteins of herpes simplex virus type 2.

1981 ◽  
Vol 39 (2) ◽  
pp. 438-446 ◽  
Author(s):  
N Balachandran ◽  
D Harnish ◽  
R A Killington ◽  
S Bacchetti ◽  
W E Rawls
Keyword(s):  
Monoclonal Antibodies ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

scholarly journals Monoclonal Antibodies to Three Non-glycosylated Antigens of Herpes Simplex Virus Type 2

1982 ◽  
Vol 63 (2) ◽  
pp. 297-305 ◽  
Author(s):  
C. McLean ◽  
A. Buckmaster ◽  
D. Hancock ◽  
A. Buchan ◽  
A. Fuller ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

Glycoproteins of herpes simplex virus type 2 as defined by monoclonal antibodies.

1982 ◽  
Vol 44 (1) ◽  
pp. 344-355 ◽  
Author(s):  
N Balachandran ◽  
D Harnish ◽  
W E Rawls ◽  
S Bacchetti
Keyword(s):  
Monoclonal Antibodies ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

scholarly journals Efficacy of Orally Administered Low Dose N-methanocarbathymidine against Lethal Herpes Simplex Virus Type-2 Infections of Mice

2011 ◽  
Vol 22 (3) ◽  
pp. 131-137 ◽  
Author(s):  
Debra C Quenelle ◽  
Deborah J Collins ◽  
Terri L Rice ◽  
Aquilur Rahman ◽  
Robert Glazer
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Viral Replication ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Low Dose ◽  
Limit Of Detection ◽  
Lethal Challenge ◽  
Simplex Virus

Background: N-methanocarbathymidine (N-MCT) has previously been shown to be effective against lethal orthopoxvirus and herpes simplex virus type-1 infections in mice. In this investigation, the antiviral activity of N-MCT was assessed against herpes simplex virus type-2 (HSV-2) in BALB/c mice. Methods: BALB/c mice were infected intranasally with a lethal challenge dose of HSV-2. N-MCT was administered orally twice daily to mice using doses of 0.01 to 100 mg/kg to determine effects on survival and on viral replication in organ and central nervous system (CNS) samples. Results: N-MCT provided significant protection from mortality even when treatments were delayed until 3 days after viral infection. Viral replication in organ and CNS samples from N-MCT-treated mice was reduced below the limit of detection after 4 days of treatment. Conclusions: These results indicated that low dose N-MCT treatment was more effective than acyclovir therapy. N-MCT may be effective against HSV disease in humans and is currently undergoing preclinical evaluation. In particular, its potential use as a combination therapy for HSV, with its differing metabolism from acyclovir, make it a promising compound to develop for human use.

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