scholarly journals Potent Vesicular Stomatitis Virus-Based Avian Influenza Vaccines Provide Long-Term Sterilizing Immunity against Heterologous Challenge

2010 ◽  
Vol 84 (9) ◽  
pp. 4611-4618 ◽  
Author(s):  
Jennifer A. Schwartz ◽  
Linda Buonocore ◽  
Amorsolo L. Suguitan ◽  
Alex Silaghi ◽  
Darwyn Kobasa ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Vesicular Stomatitis Virus ◽  
Neutralizing Antibodies ◽  
H5n1 Avian Influenza Virus ◽  
H5n1 Avian Influenza ◽  
Heterologous Challenge ◽  
Vesicular Stomatitis ◽  
Clade 1 ◽  
Pandemic Vaccine ◽  
Sterilizing Immunity

ABSTRACT The emergence in 1997 and continuance today of a highly lethal H5N1 avian influenza virus (AIV) causing human disease has raised concern about an impending pandemic and the need for a vaccine to prepare for such an occurrence. We previously generated an efficacious vesicular stomatitis virus (VSV)-based AIV vaccine expressing H5 hemagglutinin (HA) from the fifth genomic position of VSV (J. A. Schwartz et al., Virology 366:166-173, 2007). Here we have generated and characterized VSV-based vaccines that express the A/Hong Kong/156/1997 (clade 0) H5 HA from the first position of the VSV genome. These vectors induce broadly cross-neutralizing antibodies against homologous and heterologous H5N1 viruses of different clades in mice. The vaccines provide complete protection against morbidity and mortality after heterologous challenge with clade 0 and clade 1 strains in animals even 1 year after vaccination. Postchallenge pulmonary virus loads show that these vectors provide sterilizing immunity. Therefore, VSV-based AIV vaccines are potent, broadly cross-protective pandemic vaccine candidates.

scholarly journals Vesicular stomatitis virus vectors expressing avian influenza H5 HA induce cross-neutralizing antibodies and long-term protection

Virology ◽  
2007 ◽  
Vol 366 (1) ◽  
pp. 166-173 ◽  
Author(s):  
Jennifer A. Schwartz ◽  
Linda Buonocore ◽  
Anjeanette Roberts ◽  
Amorsolo Suguitan ◽  
Darwyn Kobasa ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Vesicular Stomatitis Virus ◽  
Neutralizing Antibodies ◽  
Virus Vectors ◽  
Vesicular Stomatitis

scholarly journals Development of a new candidate H5N1 avian influenza virus for pre-pandemic vaccine production

2009 ◽  
Vol 3 (6) ◽  
pp. 287-295 ◽  
Author(s):  
Jie Dong ◽  
Yumiko Matsuoka ◽  
Taronna R. Maines ◽  
David E. Swayne ◽  
Eduardo O’Neill ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Vaccine Production ◽  
H5n1 Avian Influenza Virus ◽  
H5n1 Avian Influenza ◽  
Pandemic Vaccine

scholarly journals Evaluation of a rapid test for detection of H5N1 avian influenza virus

2008 ◽  
Vol 154 (1-2) ◽  
pp. 213-215 ◽  
Author(s):  
Yixin Chen ◽  
Feihai Xu ◽  
Xiaohui Fan ◽  
Haifeng Luo ◽  
Shengxiang Ge ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Rapid Test ◽  
H5n1 Avian Influenza Virus ◽  
H5n1 Avian Influenza

scholarly journals Pathobiology of A/Chicken/Hong Kong/220/97 (H5N1) Avian Influenza Virus in Seven Gallinaceous Species

2001 ◽  
Vol 38 (2) ◽  
pp. 149-164 ◽  
Author(s):  
L. E. L. Perkins ◽  
D. E. Swayne
Keyword(s):  
Hong Kong ◽  
Avian Influenza ◽  
Pulmonary Edema ◽  
Multiorgan Failure ◽  
Clinical Manifestations ◽  
Highly Pathogenic ◽  
H5n1 Avian Influenza Virus ◽  
Multiple Organs ◽  
H5n1 Avian Influenza ◽  
Virus Localization

Direct bird-to-human transmission, with the production of severe respiratory disease and human mortality, is unique to the Hong Kong-origin H5N1 highly pathogenic avian influenza (HPAI) virus, which was originally isolated from a disease outbreak in chickens. The pathobiology of the A/chicken/Hong Kong/ 220/97 (H5N1) (HK/220) HPAI virus was investigated in chickens, turkeys, Japanese and Bobwhite quail, guinea fowl, pheasants, and partridges, where it produced 75-100% mortality within 10 days. Depression, mucoid diarrhea, and neurologic dysfunction were common clinical manifestations of disease. Grossly, the most severe and consistent lesions included splenomegaly, pulmonary edema and congestion, and hemorrhages in enteric lymphoid areas, on serosal surfaces, and in skeletal muscle. Histologic lesions were observed in multiple organs and were characterized by exudation, hemorrhage, necrosis, inflammation, or a combination of these features. The lung, heart, brain, spleen, and adrenal glands were the most consistently affected, and viral antigen was most often detected by immunohistochemistry in the parenchyma of these organs. The pathogenesis of infection with the HK/220 HPAI virus in these species was twofold. Early mortality occurring at 1-2 days postinoculation (DPI) corresponded to severe pulmonary edema and congestion and virus localization within the vascular endothelium. Mortality occurring after 2 DPI was related to systemic biochemical imbalance, multiorgan failure, or a combination of these factors. The pathobiologic features were analogous to those experimentally induced with other HPAI viruses in domestic poultry.

Re-Emergence of a Novel H5N1 Avian Influenza Virus Variant Subclade 2.2.1.1 in Egypt During 2014

2016 ◽  
Vol 64 (4) ◽  
pp. 1306-1312 ◽  
Author(s):  
M. A. Rohaim ◽  
R. F. El-Naggar ◽  
M. M. Hamoud ◽  
S. A. Nasr ◽  
E. Ismael ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Virus Variant ◽  
H5n1 Avian Influenza Virus ◽  
H5n1 Avian Influenza

Phylodynamics of H5N1 avian influenza virus in Indonesia

2012 ◽  
Vol 21 (12) ◽  
pp. 3062-3077 ◽  
Author(s):  
TOMMY TSAN-YUK LAM ◽  
CHUNG-CHAU HON ◽  
PHILIPPE LEMEY ◽  
OLIVER G. PYBUS ◽  
MANG SHI ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
H5n1 Avian Influenza Virus ◽  
H5n1 Avian Influenza
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