scholarly journals The abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal ganglia.

1997 ◽  
Vol 71 (4) ◽  
pp. 2897-2904 ◽  
Author(s):  
D Goldenberg ◽  
N Mador ◽  
M J Ball ◽  
A Panet ◽  
I Steiner
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Latent Infection ◽  
Neuronal Cells ◽  
Trigeminal Ganglia ◽  
Simplex Virus

scholarly journals Correlation between Herpes Simplex Virus Type 1 Rate of Reactivation from Latent Infection and the Number of Infected Neurons in Trigeminal Ganglia

Virology ◽  
1996 ◽  
Vol 225 (1) ◽  
pp. 72-81 ◽  
Author(s):  
John Maggioncalda ◽  
Anand Mehta ◽  
Ying Hsiu Su ◽  
Nigel W. Fraser ◽  
Timothy M. Block
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Latent Infection ◽  
Trigeminal Ganglia ◽  
Simplex Virus

Viable herpes simplex virus type 1 and varicella-zoster virus in the trigeminal ganglia of human cadavers

2013 ◽  
Vol 85 (5) ◽  
pp. 833-838 ◽  
Author(s):  
Hisako Saitoh ◽  
Yuko Momma ◽  
Hiroyuki Inoue ◽  
Daisuke Yajima ◽  
Hirotaro Iwase
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Trigeminal Ganglia ◽  
Varicella Zoster ◽  
Human Cadavers ◽  
Simplex Virus

scholarly journals Herpes simplex virus-mediated human hypoxanthine-guanine phosphoribosyltransferase gene transfer into neuronal cells.

1988 ◽  
Vol 8 (1) ◽  
pp. 457-460 ◽  
Author(s):  
T D Palella ◽  
L J Silverman ◽  
C T Schroll ◽  
F L Homa ◽  
M Levine ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Neuronal Cells ◽  
Neurological Dysfunction ◽  
Hprt Gene ◽  
Hypoxanthine Guanine Phosphoribosyltransferase ◽  
Simplex Virus

The virtually complete deficiency of the purine salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) results in a devastating neurological disease, Lesch-Nyhan syndrome. Transfer of the HPRT gene into fibroblasts and lymphoblasts in vitro and into hematopoietic cells in vivo has been accomplished by other groups with retroviral-derived vectors. It appears to be necessary, however, to transfer the HPRT gene into neuronal cells to correct the neurological dysfunction of this disorder. The neurotropic virus herpes simplex virus type 1 has features that make it suitable for use as a vector to transfer the HPRT gene into neuronal tissue. This report describes the isolation of an HPRT-deficient rat neuroma cell line, designated B103-4C, and the construction of a recombinant herpes simplex virus type 1 that contained human HPRT cDNA. These recombinant viruses were used to infect B103-4C cells. Infected cells expressed HPRT activity which was human in origin.

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