scholarly journals Prospective study of prenatal screening for Down's syndrome with free beta human chorionic gonadotrophin.

BMJ ◽  
1993 ◽  
Vol 307 (6907) ◽  
pp. 764-769 ◽  
Author(s):  
K Spencer ◽  
P Carpenter
Keyword(s):  
Prospective Study ◽  
Prenatal Screening ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Beta Human Chorionic Gonadotrophin

scholarly journals Assessment of Atypicality: An Adjunct to Prenatal Screening for Down's Syndrome That Facilitates Detection of other Abnormalities

1993 ◽  
Vol 30 (6) ◽  
pp. 578-583 ◽  
Author(s):  
D E Wright ◽  
T M Reynolds ◽  
C M Donovan
Keyword(s):  
Prenatal Screening ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Maternal Serum ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Low Risk ◽  
Risk Estimates ◽  
Risk Reporting

Current software used for assessment of the risk of Down's syndrome may give misleading risk estimates if applied to other abnormalities. Often the abnormality is reflected in maternal serum α-fetoprotein and human chorionic gonadotrophin levels and is then translated into a low risk for Down's syndrome that may not be recognized as significantly atypical of normality. We regard this as a serious deficiency in the current Down's syndrome risk reporting algorithm, and suggest a modification that allows the problem to be overcome.

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