Trimethoprim reduced dysuria in women with symptoms of urinary tract infection but negative urine dipstick test results

Background: Urine culture is the gold standard in the diagnosis of urinary tract infection (UTI), but usually takes at least 48 hours and is expensive. Urine dipstick test and microscopy are useful for early diagnosis and initiation of treatment. The current study aims to assess the diagnostic value of dipstick and microscopy of urine in the diagnosis of UTI in comparison with culture.Methods: Children aged between 3 months-15 years of age, in whom UTI was suspected clinically were included in the study. Dipstick and microscopic examination of urine were done and compared with the urine culture. Results were analyzed using sensitivity, specificity, positive predictive value and negative predictive values.Results: Total of 104 children with clinical suspicion of UTI were evaluated in the study. The specificity of nitrite is 93.94%, leucocyte esterase 75.76%, urine dipstick test (nitrite and leukocyte esterase) 96.97% and urine microscopy is 50% when compared to urine culture.Conclusions: Urine dipstick test (nitrite and leukocyte esterase) and urine microscopy can be used as screening tests to rule out or rule in UTI. This would be useful clinically as treatment could be commenced in children pending culture reports.

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Can urine dipstick test be an alternative to detect urinary tract infection in limited resource setting? – A validity study from Bangalore, India

Journal of Family Medicine and Primary Care ◽

10.4103/jfmpc.jfmpc_696_19 ◽

2020 ◽

Vol 9 (2) ◽

pp. 561

Author(s):

LeeberkR Inbaraj ◽

AbilashJ Bhansali ◽

CarolinE George ◽

Gift Norman

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Limited Resource ◽

Validity Study ◽

Dipstick Test ◽

Urine Dipstick ◽

Limited Resource Setting ◽

Resource Setting ◽

Urine Dipstick Test

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Urine dipstick test for diagnosing urinary tract infection

Paediatrica Indonesiana ◽

10.14238/pi53.6.2013.315-9 ◽

2013 ◽

Vol 53 (6) ◽

pp. 315

Author(s):

Syarifah Julinawati ◽

Oke Rina ◽

Rosmayanti Rosmayanti ◽

Rafita Ramayati ◽

Rusdidjas Rusdidjas

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Low Cost ◽

Diagnostic Study ◽

Dipstick Test ◽

Predictive Values ◽

Urine Dipstick ◽

Prompt Treatment ◽

Urine Dipstick Test

Background Urinary tract infection (UTI) is a common diseasein children. Approximately 3-5% of girls and 1 % of boys developa UTI. In children, prompt treatment is essential because UTImay be a risk factor for developing renal insufficiency or end stagerenal disease. Howevet; prompt treatment depends on having arapid diagnosis. Urine dipstick testis a useful and commonly usedbecause it is low cost and gives rapid results, compared to urinecultures for diagnosing UTis. However, the diagnostic accuracyof the urine dipstick test is debatable.Objective To compare urine dipstick test (leukocyte esterase,nitrite, and combined leukocyte es terase and nitrite) to urineculture for diagnosing UTis.Methods A diagnostic study was held in H. Adam Malik Hospitalfrom May to June 2010. There were 70 children aged 2 to 14years and recruited by consecutive sampling. Two midstreamurine specimens were collected from subjects after cleaning theexternal urethral orifice. The first specimen was used for urinedipstick testing for leukocyte esterase and nitrite. The secondurine specimen was cultured in the laboratory. Urinalysis forleukocyte esterase and nitrite studies were performed with freshand uncentrifuged urine. Leukocyte esteras e and nitrite causeda change in dipstick color apparent within 2 minutes. Urinalyseswere considered to be positive for UTI if either leukocyte esteraseor nitrite were positive. The results of urine culture were used asthe golden standard.Results The sensitivities of leukocyte esterase and nitratetests were 90 .5% and 73.8%, respectively. However, thesensitivity for combined leukocyte esterase and nitrite testwas 96.4%. Nitrite test was more specific (60.7%) than theleukocyte esterase test (39.3%). The specificity of both teststaken together was 64.3% . For leukocyte esterase alone, nitratealone, and the two combined the positive predictive values(PPV) were 69.1 %, 73.8%, and 64.3.%, respectively, and thenegative predictive values (NPV) were 73.3%, 60.7%, and96.4%, respectively.Conclusion Urine dipstick test for leukocyte esterase and nitritecombined may be a good alternative diagnostic test for UTis inchildren than leukocyte esterase or nitrite by themselves in areaswith limited resources.

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