scholarly journals Retreatment with interferon plus ribavirin of chronic hepatitis C non-responders to interferon monotherapy: a meta-analysis of individual patient data

Gut ◽  
2002 ◽  
Vol 51 (6) ◽  
pp. 864-869 ◽  
Author(s):  
C Camma
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data ◽  
Interferon Monotherapy

scholarly journals Re-treatment with interferon plus ribavirin of chronic hepatitis C nonresponders to interferon monotherapy: A meta-analysis of individual patient data

2001 ◽  
Vol 33 ◽  
pp. A60
Author(s):  
Calogero Cammá ◽  
Savino Bruno ◽  
Filippo Schepis ◽  
Anna Gramenzi ◽  
Alessandra Mangia ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data ◽  
Interferon Monotherapy

Combination therapy with amantadine and interferon in naı̈ve patients with chronic hepatitis C: meta-analysis of individual patient data from six clinical trials

2004 ◽  
Vol 40 (3) ◽  
pp. 478-483 ◽  
Author(s):  
Alessandra Mangia ◽  
Gioacchino Leandro ◽  
Beat Helbling ◽  
Eberhard L Renner ◽  
Marco Tabone ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Combination Therapy ◽  
Chronic Hepatitis C ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data

Effect of peginterferon alfa-2a on liver histology in chronic hepatitis C: A meta-analysis of individual patient data

Hepatology ◽  
2004 ◽  
Vol 39 (2) ◽  
pp. 333-342 ◽  
Author(s):  
Calogero Cammà ◽  
Danilo Di Bona ◽  
Filippo Schepis ◽  
E. Jenny Heathcote ◽  
Stefan Zeuzem ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data ◽  
Liver Histology ◽  
Peginterferon Alfa

Relationship Between Steatosis, Inflammation, and Fibrosis in Chronic Hepatitis C: A Meta-Analysis of Individual Patient Data

2006 ◽  
Vol 130 (6) ◽  
pp. 1636-1642 ◽  
Author(s):  
Gioacchino Leandro ◽  
Alessandra Mangia ◽  
Jason Hui ◽  
Paolo Fabris ◽  
Laura Rubbia–Brandt ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data

scholarly journals Chronic hepatitis C: Interferon retreatment of relapsers. A meta-analysis of individual patient data

Hepatology ◽  
1999 ◽  
Vol 30 (3) ◽  
pp. 801-807 ◽  
Author(s):  
Calogero Cammà ◽  
Marco Giunta ◽  
Liliana Chemello ◽  
Alfredo Alberti ◽  
Hidenori Toyoda ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data ◽  
Interferon Retreatment

Combination Therapy of Interferon and Ribavirin Versus Interferon Monotherapy in Treatment of Chronic Hepatitis C: A Meta-analysis of Clinical Trials

2006 ◽  
Vol 19 (5) ◽  
pp. 265-274
Author(s):  
Yousef S. Khader ◽  
Anmar Dweek ◽  
Ahmad Alkafajei ◽  
Atallah Z. Rabi'
Keyword(s):  
Clinical Trials ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Combination Therapy ◽  
Chronic Hepatitis C ◽  
Virological Response ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Interferon Monotherapy ◽  
Chronic Hepatitis C Patients

This meta-analysis was conducted to assess the efficacy and safety of interferon and ribavirin combination therapy (CT) versus interferon monotherapy (IMT) in inducing sustained response in interferon-naïve, relapser, and nonresponder chronic hepatitis C patients. A literature search was performed using the MEDLINE database for clinical trials published in the period between 1995 and 2003. A total of 31 randomized trials and 7 nonrandomized trials comparing CT with interferon alone or comparing different dose regimens of CT were included in this meta-analysis. The primary outcome measure was sustained virological response. The summary estimate of the odds ratio was obtained using the random effect model. The study showed that sustained virological response rate was significantly higher in interferon-naïve, relapser, and nonrespondent chronic hepatitis C patients who were on CT compared to IMT (odds ratio = 3.23, 17.65, and 4.71, respectively). There was no statistically significant difference in virological and biochemical responses between different dose regimens of CT. Side effects, dose reduction, and treatment discontinuation rates were significantly higher in patients receiving CT compared with IMT. Treatment with interferon plus ribavirin has a significant benefit on the virological and biochemical response in patients with chronic hepatitis C irrespective to the previous treatment, and it should be considered the treatment of choice in naïve, relapser, and nonrespondent chronic hepatitis C patients.

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