Presynaptic Action of Central Depressant Drugs: Inhibition of Depolarization–Secretion Coupling

1972 ◽  
Vol 50 (3) ◽  
pp. 279-284 ◽  
Author(s):  
D. M. J. Quastel ◽  
J. T. Hackett ◽  
K. Okamoto
Keyword(s):  
Osmotic Pressure ◽  
Chloral Hydrate ◽  
Locust Muscle ◽  
Endplate Potential ◽  
Mouse Diaphragm ◽  
Miniature Endplate Potential ◽  
Diaphragm In Vitro ◽  
Potential Frequency ◽  
Central Depressant

Chlorpromazine, like raised osmotic pressure, not only increases spontaneous miniature endplate potential frequency (F) in mouse diaphragm (in vitro) but also depresses the slope of log F versus focal presynaptic depolarization. It also depresses the slope of log F versus [Ca], in raised K+ (constant depolarization). Similar effects are seen with pentobarbital, chloral hydrate, chloroform, and lowered pH. The drugs have similar actions in locust muscle, where the transmitter is not acetylcholine.

scholarly journals Changes in the structure of neuromuscular junctions caused by variations in osmotic pressure.

1976 ◽  
Vol 69 (3) ◽  
pp. 521-538 ◽  
Author(s):  
A W Clark
Keyword(s):  
Osmotic Pressure ◽  
Synaptic Vesicles ◽  
Rana Pipiens ◽  
Neuromuscular Junctions ◽  
Presynaptic Membrane ◽  
Normal Position ◽  
Structural Modifications ◽  
Endplate Potential ◽  
Miniature Endplate Potential ◽  
Potential Frequency

Neuromuscular junctions of the frog, Rana pipiens, were examined for structural modifications produced by exposure to increased and reduced osmotic pressure (pi). Preparations exposed to increased pi for varying lengths of time were fixed with either OSO4-Veronal with and without calcium, glutaraldehyde-phosphate, or glutaraldehyde-formaldehyde-phosphate as primary fixatives. The greatest difference between the fixatives was seen in preparations exposed to increased pi for 5 min, corresponding to the time when miniature endplate potential frequency is highest. The 5-min OSO4 calcium-free preparations appeared comparatively normal, while those fixed with OSO4 and 2 mM CaCl2 or aldehyde-phosphate had wide infoldings of the presynaptic membrane and a reduced number of synaptic vesicles. Aldehyde-phosphate had the same effect on mouse diaphragm. Another series of frog preparations were conditioned to elevated pi and then returned to normal Ringer's for varying times before fixation in OSO4-phosphate. Preparations fixed 2 min after their return to normal Ringer's showed marked disruption of the presynaptic membrane as well as apparently rupturing vesicles. If fixed after 10 min, terminals were depleted of vesicles although the presynaptic membrane had returned to its normal position and appearance.

scholarly journals Mode of inhibitory actions of acute and chronic chloroquine administration on the electrically stimulated mouse diaphragm in vitro

1990 ◽  
Vol 101 (1) ◽  
pp. 133-139 ◽  
Author(s):  
F.K. Okwuasaba ◽  
J.A.M. Otubu ◽  
F.V. Udoh
Keyword(s):  
Mouse Diaphragm ◽  
Diaphragm In Vitro

Interacting effects of Ca2+ and hypoxia in the induction of sarcolemmal damage in mouse diaphragm in vitro

1995 ◽  
Vol 90 (4) ◽  
pp. 411-414 ◽  
Author(s):  
N. J. Bannister ◽  
S. J. Publicover
Keyword(s):  
Mouse Diaphragm ◽  
Diaphragm In Vitro

The effect of insulin on the formation of glycogen by the mouse diaphragm in vitro

1966 ◽  
Vol 22 (4) ◽  
pp. 241-242
Author(s):  
A. J. Moody ◽  
J. P. Felber
Keyword(s):  
Mouse Diaphragm ◽  
Diaphragm In Vitro

scholarly journals Depression of miniature endplate potential frequency by acetylcholine and its analogues in frog

1991 ◽  
Vol 104 (4) ◽  
pp. 1024-1032 ◽  
Author(s):  
E.E. Nikolsky ◽  
E.A. Bukharaeva ◽  
E.G. Strunsky ◽  
F. Vyskočil
Keyword(s):  
Endplate Potential ◽  
Miniature Endplate Potential ◽  
Potential Frequency

scholarly journals Potentiation of miniature endplate potential frequency by ATP in Xenopus tadpoles

1993 ◽  
Vol 108 (1) ◽  
pp. 236-241 ◽  
Author(s):  
Wen-Mei Fu ◽  
Shiau-Hui Yang ◽  
Shoei-Yn Lin-Shiau
Keyword(s):  
Endplate Potential ◽  
Miniature Endplate Potential ◽  
Potential Frequency

N-acetylcysteine Delays Fatigue of Mouse Diaphragm In Vitro, But Not Soleus or EDL Muscles

2008 ◽  
Vol 40 (Supplement) ◽  
pp. S76
Author(s):  
Leonardo F. Ferreira ◽  
Laura A. Ashley ◽  
Michael B. Reid
Keyword(s):  
Mouse Diaphragm ◽  
Diaphragm In Vitro

scholarly journals Miniature endplate potential frequency and amplitude determined by an extension of Campbell's theorem

1985 ◽  
Vol 47 (2) ◽  
pp. 183-202 ◽  
Author(s):  
J.R. Segal ◽  
B. Ceccarelli ◽  
R. Fesce ◽  
W.P. Hurlbut
Keyword(s):  
Endplate Potential ◽  
Miniature Endplate Potential ◽  
Potential Frequency
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