Antagonism of substance P induced facilitation of central neuronal activity by 2,4-dinitrophenol and depressant agents

1978 ◽  
Vol 56 (3) ◽  
pp. 527-530 ◽  
Author(s):  
Bhagavatula R. Sastry

2,4-Dinitrophenol, pentobarbital, thiopental, methoxyflurane, and halothane more often antagonized the facilitatory effects of substance P than of acetylcholine on the activity of spinal dorsal horn neurons (of unanaesthetized decerebrated and spinalized cats) as well as interpeduncular and cerebral cortical cells (of either rats anaesthetized with methoxyflurane, nitrous oxide, and oxygen or 'cerveau isolé' rats). The results of the studies indicate that the excitatory effects of substance P on central neurons are extremely sensitive to anaesthesia.

1999 ◽  
Vol 88 (4) ◽  
pp. 893-897 ◽  
Author(s):  
Yoshiya Miyazaki ◽  
Takehiko Adachi ◽  
Jun Utsumi ◽  
Tsutomu Shichino ◽  
Hajime Segawa

Peptides ◽  
1988 ◽  
Vol 9 (3) ◽  
pp. 651-660 ◽  
Author(s):  
M. Randic ◽  
S. Jeftinija ◽  
L. Urban ◽  
C. Raspantini ◽  
K. Folkers

Pain ◽  
2008 ◽  
Vol 134 (1) ◽  
pp. 24-31 ◽  
Author(s):  
Stefan K. Georgiev ◽  
Tatsuro Kohno ◽  
Miho Ikoma ◽  
Tomohiro Yamakura ◽  
Hiroshi Baba

1999 ◽  
Vol 88 (4) ◽  
pp. 893-897 ◽  
Author(s):  
Yoshiya Miyazaki ◽  
Takehiko Adachi ◽  
Jun Utsumi ◽  
Tsutomu Shichino ◽  
Hajime Segawa

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