Excessive dietary salt promotes aortic stiffness in murine renovascular hypertension
2020 ◽
Vol 318
(5)
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pp. H1346-H1355
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High dietary salt exaggerates hypertension in multiple experimental models. Here we demonstrate that a high-salt diet produces a greater increase in arterial blood pressure at 1 wk after induction of 2-kidney, 1-clip (2K1C) hypertension but not at 3 wk. Interestingly, 2K1C mice fed a high-salt diet displayed an exaggerated pulse pressure, elevated pulse wave velocity, and reduced endothelium-dependent vasodilation of the aorta but not mesenteric arteries. These findings suggest that dietary salt may interact with underlying cardiovascular disease to promote selective vascular dysfunction and aortic stiffness.
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2005 ◽
Vol 288
(4)
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pp. H1557-H1565
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2002 ◽
Vol 543
(1)
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pp. 255-260
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Keyword(s):
1999 ◽
Vol 276
(6)
◽
pp. R1749-R1757
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