Stimulation of renin release in perfused kidney by low calcium and high magnesium

1977 ◽  
Vol 232 (4) ◽  
pp. F377-F382 ◽  
Author(s):  
J. S. Fray
Keyword(s):  
Sodium Excretion ◽  
Calcium Concentration ◽  
Perfusion Pressure ◽  
Rat Kidney ◽  
Sodium Concentration ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Low Calcium ◽  
Perfused Rat Kidney ◽  
Stimulation Of

These experiments were designed to test whether changing perfusate calcium or magnesium concentrations affected renin release in the isolated perfused rat kidney, and whether kidneys removed from sodium-loaded or sodium-deprived rats released the same amount of renin in response to identical stimuli. Kidneys were perfused with Kreb-Henseleit solution containing albumin. Renin release was inversely related to perfusate calcium concentration, whereas renin release was directly related to perfusate magnesium. Although a low calcium medium or low perfusion pressure (50 mmHg) stimulated renin release, the release was substantially greater in the sodium-deprived rats. Increasing the perfusate sodium concentration from 85 to 206 mM increased excretion, but did not alter renin release. It is concluded that a) low perfusate calcium and high magnesium concentrations stimulate renin release, b) kidneys removed from sodium-deprived rats released substantially more renin thatn those from sodium-loaded rats, and c) changing perfusate sodium concentration alters sodium excretion, but does not affect renin release.

Nitrendipine-Induced Stimulation of Renin Release by the Isolated Perfused Rat Kidney

1985 ◽  
Vol 180 (1) ◽  
pp. 133-136 ◽  
Author(s):  
R. Loutzenhiser ◽  
M. Epstein ◽  
C. Horton ◽  
R. Hamburger
Keyword(s):  
Rat Kidney ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney ◽  
Stimulation Of

Alpha 2-adrenoceptors and sodium reabsorption in the isolated perfused rat kidney

1984 ◽  
Vol 247 (4) ◽  
pp. F680-F685 ◽  
Author(s):  
D. D. Smyth ◽  
S. Umemura ◽  
W. A. Pettinger
Keyword(s):  
Adenylate Cyclase ◽  
Sodium Excretion ◽  
Perfusion Pressure ◽  
Rat Kidney ◽  
Blocking Agent ◽  
Sodium Reabsorption ◽  
Sodium Retention ◽  
Sympathoadrenal System ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney

Alpha 2-Adrenoceptors are known to inhibit adenylate cyclase in a number of tissues, but their function in the kidney is unknown. Adenylate cyclase and sodium excretion were stimulated with furosemide (30 microM) in the rat kidney perfused with Krebs-Henseleit solution (albumin 6.5 g/100 ml, 36 degrees C). beta-Adrenoceptors and alpha 1-adrenoceptors were blocked by propranolol (100 nM) and prazosin (30 nM) in the perfusate. Urinary cAMP and sodium excretion increased with furosemide. Activation of alpha 2-adrenoceptors with epinephrine (28 nM) caused no change in perfusion pressure or flow but decreased urinary cAMP and sodium excretion. These effects of epinephrine were reversed by the alpha 2-selective adrenoceptor blocking agent yohimbine (300 nM). Thus, in the setting of furosemide-stimulated sodium excretion and an associated elevation of adenylate cyclase, alpha 2-adrenoceptor stimulation resulted in sodium retention and inhibition of adenylate cyclase. By this receptor mechanism the sympathoadrenal system may contribute to retention of sodium.

Blockade of Renin Release by Lanthanum

1974 ◽  
Vol 48 (s2) ◽  
pp. 31s-32s
Author(s):  
A. G. Logan ◽  
I. Tenyi ◽  
T. Quesada ◽  
W. S. Peart ◽  
A. S. Breathnach ◽  
...  
Keyword(s):  
Rat Kidney ◽  
Renin Secretion ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Renal Vasoconstriction ◽  
Perfused Rat Kidney ◽  
Stimulation Of

1. The effects of lanthanum on renin release and renal vasoconstriction were studied in the isolated perfused rat kidney. 2. Lanthanum reduced noradrenaline-induced renal vasoconstriction. 3. Lanthanum prevented isoprenaline-induced and glucagon-induced stimulation of renin secretion.

Influence of pulsatile perfusion upon renin release from the isolated perfused rat kidney

1990 ◽  
Vol 415 (6) ◽  
pp. 713-717 ◽  
Author(s):  
Rainer Nobiling ◽  
Klaus Münter ◽  
Christian P. Bührle ◽  
Eberhard Hackenthal
Keyword(s):  
Rat Kidney ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney ◽  
Pulsatile Perfusion

scholarly journals Effects of atrial natriuretic peptide on renal function and renin release in the isolated perfused rat kidney.

1987 ◽  
Vol 28 (2) ◽  
pp. 221-227 ◽  
Author(s):  
Shosaku NARUMI ◽  
Toshiyuki YASUI ◽  
Mamoru YOSHIZAWA ◽  
Minako KAWAMURA ◽  
Hiromichi SUZUKI ◽  
...  
Keyword(s):  
Renal Function ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Rat Kidney ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney ◽  
Atrial Natriuretic

Stimulation of Renin Secretion by Frusemide and Diazoxide in the Isolated Rat Kidney

1976 ◽  
Vol 51 (s3) ◽  
pp. 101s-104s
Author(s):  
R. Vandongen ◽  
Dianne M. Greenwood
Keyword(s):  
Perfusion Pressure ◽  
Rat Kidney ◽  
Renal Perfusion ◽  
Urine Flow ◽  
Renin Secretion ◽  
Stimulatory Action ◽  
Vasodilatory Effect ◽  
Perfused Rat Kidney ◽  
Site Of Action ◽  
Stimulation Of

1. The effect of diazoxide (17·3 μmol min—1 g—1) and frusemide (0·12 μmol min—1 g—1) on renin secretion was examined in the isolated perfused rat kidney. These substances are potential renal vasodilators with opposite effects on urine sodium excretion. 2. Both agents significantly increased renin secretion rate above control values. In the case of frusemide this was not altered by ureteric occlusion and presumed absence of urine flow. 3. Mean renal perfusion pressure decreased to the same extent with diazoxide and frusemide infusion as in the control experiments and no additional vasodilatory effect was observed on the basis of changes in flow rate of perfusate. 4. These observations identify an intrarenal site of action for diazoxide and frusemide on renin secretion. The apparent independence of this stimulatory action on renal vasodilatation and urine flow suggests a direct effect on the renin-producing cell.

scholarly journals Regulation of kallikrein and renin release by the isolated perfused rat kidney

1983 ◽  
Vol 24 (1) ◽  
pp. 58-65 ◽  
Author(s):  
Jiro Misumi ◽  
François Alhenc-Gelas ◽  
Michel Marre ◽  
Jeanine Marchetti ◽  
Pierre Corvol ◽  
...  
Keyword(s):  
Rat Kidney ◽  
Renin Release ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney
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