Phasic capillary pressure determined by arterial occlusion in intact dog lung lobes

1989 ◽  
Vol 67 (6) ◽  
pp. 2205-2211 ◽  
Author(s):  
Y. Yamada ◽  
M. Suzukawa ◽  
M. Chinzei ◽  
T. Chinzei ◽  
N. Kawahara ◽  
...  
Keyword(s):  
Capillary Pressure ◽  
Vascular Resistance ◽  
Control Period ◽  
Arterial Occlusion ◽  
Lung Lobe ◽  
Pulmonary Capillary ◽  
Pulmonary Capillary Pressure ◽  
Lower Lung ◽  
Pulmonary Arterial ◽  
Electrocardiogram Ecg

In six open-chest dogs, electrocardiogram- (ECG) controlled pulmonary arterial occlusion was performed during the control period and during the infusions of serotonin and histamine. A temporal series of instantaneous pulmonary capillary pressure and the longitudinal distributions of vascular resistance and compliance were evaluated in the intact left lower lung lobe. In the control period, we found a significant phasic variation of pulmonary capillary pressure (Pc) with the cardiac cycle. The ratio of arterial to venous resistances (Ra/Rv) was 6:4, and the ratio of arterial to capillary compliances (Ca/Cc) was 1:11. During the infusions of serotonin and histamine, Pc showed similar phasic variations, despite significant hemodynamic changes induced by these agents. Serotonin predominantly increased Ra, whereas histamine predominantly increased Rv. The ratio of Rv to the total resistance decreased significantly from 0.42 to 0.32 during the infusion of serotonin and increased significantly to 0.62 during the infusion of histamine. The data suggest that phasic Pc determined by ECG-controlled arterial occlusion reflects the pulsatility in the pulmonary microvascular bed under control conditions and after alterations of the pulmonary vascular resistance by serotonin and histamine.

A Comparison of Pulmonary Arterial Occlusion Algorithms for Estimation of Pulmonary Capillary Pressure

1999 ◽  
Vol 160 (1) ◽  
pp. 162-168 ◽  
Author(s):  
ANDREW A. PELLETT ◽  
ROYCE W. JOHNSON ◽  
GERALYNN G. MORRISON ◽  
MICHAEL S. CHAMPAGNE ◽  
BENNETT P. DeBOISBLANC ◽  
...  
Keyword(s):  
Capillary Pressure ◽  
Arterial Occlusion ◽  
Pulmonary Capillary ◽  
Pulmonary Capillary Pressure ◽  
Pulmonary Arterial

Pulmonary capillary pressure during exercise in horses

1996 ◽  
Vol 80 (5) ◽  
pp. 1792-1798 ◽  
Author(s):  
A. K. Sinha ◽  
R. D. Gleed ◽  
T. S. Hakim ◽  
A. Dobson ◽  
K. J. Shannon
Keyword(s):  
Capillary Pressure ◽  
Maximal Exercise ◽  
Arterial Occlusion ◽  
Esophageal Pressure ◽  
Maximal Heart Rate ◽  
Pulmonary Capillary ◽  
Pulmonary Capillary Pressure ◽  
Occlusion Technique ◽  
Pulmonary Arterial ◽  
The Difference

The object of this study was to relate pulmonary capillary pressure to arterial and wedge pressures during exercise. Pulmonary vascular pressures were measured in six standardbred horses exercising at speeds equivalent to 75, 90, and 100% of maximal heart rate. Vascular pressures were measured with transducer-tip catheters and expressed relative to esophageal pressure. Pulmonary capillary pressure was estimated by the arterial-occlusion technique modified for exercise. Mean pulmonary arterial, capillary and wedge pressures increased from 30.5 +/- 6.3, 17.8 +/- 4.3, and 13.4 +/- 1.6 mmHg, respectively, at rest, to 70.5 +/- 5.2, 42.1 +/- 5.3, and 38.4 +/- 5.6 mmHg, respectively, at maximal exercise. The largest part of the increase occurred during the first level of exertion. With exercise, the pressure across the lung barely doubled at a time when the cardiac output would have increased at least fivefold. Thus the absolute resistance in both pre- and postcapillary segments must have decreased. The capillary and wedge pressures rose similarly, whereas the difference between them did not change with exertion. The fractional resistance of the precapillary segment increased with exercise. The postcapillary resistance, initially 28% of the total pulmonary vascular resistance, fell to 9% at maximal exercise. The rise (to approximately 45 mmHg) in pulmonary capillary pressure with exertion is consistent with an increase in transvascular filtration.

Pulmonary vascular response to leukotriene D4 in unanesthetized sheep: role of thromboxane

1986 ◽  
Vol 60 (3) ◽  
pp. 765-769 ◽  
Author(s):  
T. C. Noonan ◽  
A. B. Malik
Keyword(s):  
Capillary Pressure ◽  
Pulmonary Veins ◽  
Thromboxane B2 ◽  
Base Line ◽  
Vascular Response ◽  
Leukotriene D4 ◽  
Pulmonary Hemodynamic ◽  
Pulmonary Capillary ◽  
Pulmonary Capillary Pressure ◽  
Pulmonary Arterial

We examined the pulmonary vascular response to an intravenous leukotriene D4 (LTD4) injection of (1 microgram X kg-1 X min-1 for 2 min) immediately followed by infusion of 0.133 microgram X kg-1 X min-1 for 15 min in awake sheep prepared with lung lymph fistulas. LTD4 resulted in rapid generation of thromboxane A2 as measured by an increase in plasma thromboxane B2 concentration. The thromboxane B2 generation was associated with increases in pulmonary arterial and pulmonary arterial wedge pressures while left atrial pressure did not change significantly. Pulmonary lymph flow (Qlym) increased (P less than 0.05) transiently from base line 6.87 +/- 1.88 (SE) ml/h to maximum value of 9.77 +/- 1.27 at 15 min following the LTD4 infusion. The maximum increase in Qlym was associated with an increase in the estimated pulmonary capillary pressure. The increase in Qlym was not associated with a change in the lymph-to-plasma protein concentration (L/P) ratio. Thromboxane synthetase inhibition with dazoxiben (an imidazole derivative) prevented thromboxane B2 generation after LTD4 and also prevented the increases in pulmonary vascular pressures and Qlym. We conclude that LTD4 in awake sheep increases resistance of large pulmonary veins. The small transient increase in Qlym can be explained by the increase in pulmonary capillary pressure. Thromboxane appears to mediate both the pulmonary hemodynamic and lymph responses to LTD4 in sheep.

Estimation of Pulmonary Capillary Pressure in Intact Dog Lungs Using the Arterial Occlusion Technique

1990 ◽  
Vol 141 (6) ◽  
pp. 1602-1602 ◽  
Author(s):  
Doris K. Cope ◽  
Ronald C. Allison ◽  
John N. Miller ◽  
James C. Parker ◽  
Aubrey E. Taylor
Keyword(s):  
Capillary Pressure ◽  
Arterial Occlusion ◽  
Pulmonary Capillary ◽  
Pulmonary Capillary Pressure ◽  
Occlusion Technique

A1175 ADEQUACY OF THE SWAN-GANZ CATHETER FOR CALCULATION OF PULMONARY CAPILLARY PRESSURE AFTER ARTERIAL OCCLUSION

1990 ◽  
Vol 73 (3A) ◽  
pp. NA-NA
Author(s):  
V. Lenzi ◽  
E. M. Camporesi ◽  
T. S. Hakim
Keyword(s):  
Capillary Pressure ◽  
Arterial Occlusion ◽  
Pulmonary Capillary ◽  
Pulmonary Capillary Pressure

On the Estimation of Pulmonary Capillary Pressure from Arterial Occlusion

1989 ◽  
Vol 140 (5) ◽  
pp. 1228-1236 ◽  
Author(s):  
Christopher A. Dawson ◽  
Thomas A. Bronikowski ◽  
John H. Linehan ◽  
Steven T. Haworth ◽  
David A. Rickaby
Keyword(s):  
Capillary Pressure ◽  
Arterial Occlusion ◽  
Pulmonary Capillary ◽  
Pulmonary Capillary Pressure

scholarly journals THE EFFECT OF INTRAVENOUS INFUSIONS OF PHYSIOLOGIC SALINE SOLUTION ON THE PULMONARY ARTERIAL AND PULMONARY CAPILLARY PRESSURE IN MAN 1

1951 ◽  
Vol 30 (4) ◽  
pp. 345-352 ◽  
Author(s):  
Joseph T. Doyle ◽  
Joseph S. Wilson ◽  
E. Harvey Estes ◽  
James V. Warren
Keyword(s):  
Capillary Pressure ◽  
Saline Solution ◽  
Intravenous Infusions ◽  
Pulmonary Capillary ◽  
Pulmonary Capillary Pressure ◽  
Physiologic Saline ◽  
Pulmonary Arterial

Derivation of pulmonary capillary pressure from arterial occlusion in intact conditions

1994 ◽  
Vol 22 (6) ◽  
pp. 986-993 ◽  
Author(s):  
ERIC GILBERT ◽  
TAWFIC S. HAKIM
Keyword(s):  
Capillary Pressure ◽  
Arterial Occlusion ◽  
Pulmonary Capillary ◽  
Pulmonary Capillary Pressure
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