Safety and Efficacy of Repeat Doses of Allogeneic Mesenchymal Stem Cells in Patients with Age Related Frailty

Age-related frailty is a common geriatric condition characterized by a decline in physical and immunological capacity that is associated with depletion of endogenous stem cells and leads to increased vulnerability for adverse health outcomes. Allogeneic mesenchymal stem cells (allo-MSCs) exert immunomodulatory effects and promote tissue repair, which may be able to impede the negative effects of the aging process. The objective of this study was to explore the safety and efficacy of repeated infusions of allo-MSCs in subjects with aging-frailty. Mean age at time of first and second infusions was 75.5 and 77 years of age, respectively. In this open-label clinical trial, 24 participants received two intravenous infusions of allo-MSCs with an average interval of 17.6 months between doses. Safety endpoints included incidence of treatment-emergent serious adverse events (TE-SAEs) within 1-month post-infusion and increase in Panel Reactive Antibodies (PRAs) at 6-months post-infusion. Primary efficacy endpoint was change in 6-minute walk test (6MWT) distance at 6-months post-infusion. No TE-SAEs occurred within 1-month post-infusion. PRAs remained stable throughout the study, indicating no evidence of immune rejection. 6MWT increased by 42 meters after the first infusion (P=0.018). Eighteen months later elevation persisted (P=0.026), but did not increase further after the second infusion. In summary, repeated intravenous infusions of allo-MSCs were safe in participants with age-related frailty and showed remarkable improvement in physical performance. Given the excellent safety and efficacy profiles demonstrated in this study, larger clinical trials are warranted to further quantify the efficacy of repeated dosing of allo-MSCs in this multisystem disorder.

A new combination treatment for lupus vulgaris

A new method of combined treatment for lupus vulgaris is offered by Demuth (Dermal. Ztschr. Bd. 56, H. 2/3, 29), which he tested on "large material" and which consists in the fact that the patient is lubricated from the outside with the composition: ac. pyrogall., resorcini albi, ac. salicyl aa 7.0, talci ven., gelanthi Unna aa 5.0, and in addition, intravenous infusions of sulfates (Godyl, Plospanine) at a dose of 5 kb are used. see 2% solution daily. The author points out that the ointment treatment works quite vigorously in small lesions, but in large lesions, the proposed combination is recommended, the action of which is based on the fact that the pyrogall ointment is better tolerated, the convalescent tissue granulates more intensively and, finally, relapses are very rare.

Why do Patients with Acute Pneumonia Receive Intravenous Infusions?

Currently, almost all urgently hospitalized patients immediately get access to the venous bed and begin to receive an infusion of solutions. This priority of this procedure is due not only to the need to have the most effective way of administering medications, but also to compensate for the loss of fluid, which in acute diseases has many reasons for this. Further recommendations for the correction of water-electrolyte and volume losses and the choice of the infusion rate are determined by the general criteria for their diagnosis in accordance with the parameters of the large circle of blood circulation. Considering AP, first of all, as a result of infection and not focusing on the localization of the process, modern medicine does not make exceptions in this therapeutic direction for patients with inflammation of the lung tissue.

Quinine as a remedy for enhancing labor contractions of the uterus Werner (Monatsschr. F. Geb. u. Gyn., Bd. XLVIII; Zentr. F. Gyn., 1919)

The real enthusiasm with which the introduction of pituitrin and other pituitary preparations into obstetric practice as a means of enhancing labor contractions of the uterus was greeted among German obstetricians has apparently subsided in recent years, and they have returned to the old remedy. for this purpose, quinine. Werner (Monatsschr. F. Geb. U. Gyn., Bd. XLVIII; Zentr. F. Gyn., 1919) used hydrochloric acid quinine in 5% solution in the form of intravenous infusions (10 cc. S.), And each infusion was accompanied by injecting the same dose of quinine into the muscles

Intravenous and combined methods of treatment of articular rheumatism

In recent years, we have used the following methods in the treatment of articular rheumatism: 1) intravenous infusion of the so-called Attritin 16% salicylic sodium solution + 4% coffeini n.- salic solution. 2) Intramuscular injections of milk in combination with intravenous infusions of Attritin'a. 3) Intravenous infusion of opsonized salicylic sodium and 4) Natr. salic, ex 10-12.0-200.0 per os - 4-6 tablespoons per day in combination with subcutaneous injections of autologous blood.

Anti-B-cell therapy in patients with neuromyelitis optica spectrum disorders

Neuromyelitis optica spectrum disorders (NMOSDs) are a group of central nervous system autoimmune diseases characterized by similar clinical manifestations, optic neuritis, and transverse myelitis being the most frequent among them. In most cases, the pathogenesis of NMOSDs is associated with autoantibodies to aquaporin-4 (AQP4-IgG). However, AQP4-IgG is not detected in at least 10-20% of patients with NMOSDs. In this subgroup and in patients with isolated transverse myelitis or optic neuritis, IgG antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) were detected. Patients seronegative for both AQP4-IgG and MOG-IgG have also been described.Objective: to evaluate rituximab (RTX) effectiveness in preventing relapses and disability in patients with NMOSDs.Patients and methods. The study included 27 patients with NMOSDs (9 men and 18 women) aged 20-51 years who received RTX in 2019-2021. The treatment protocol included intravenous infusions of 1000 mg of RTX on the 1st and 15th days, the second and subsequent courses (maintenance therapy) - intravenous infusions of 1000 mg of RTX once every six months. Treatment effectiveness was assessed by the average annualized relapse rate, the median changes of the Expanded Disability Status Scale (EDSS), and based on the magnetic resonance imaging (MRI) changes.Results and discussion. The annualized relapse rate at baseline and 18 months after the start of treatment was: all patients (n=27) — 0.6±0.3 and 0.07±0.27(p<0.0001); AQP4-IgG+ patients (n=6) — 1.1±0.9 and 0.17±0.41 (p=0.028); MOG-IgG+ patients (n=14) — 0.4±0.3 and 0.07±0.28(p=0.001); AQP4-IgG-, MOG-IgG-patients (n=7) — 0.8±0.4 and 0.0±0.0 (p=0.018). The EDSSscore at baseline and 18months after the start of treatment was: all patients — 4.5 [3.25; 6.0] and 4.0 [3.0; 5.75] (p=0.679); AQP4-IgG+ — 3.5 [2.625; 4.75] and 3.5 [2.5; 4.5] (p=0.869); MOG-IgG+ - 5.5[3.75; 6.5] and 5.5[2.75; 6.25] (p=0.465); AQP4-IgG-, MOG-IgG- - 4.0[3.75; 5.25] and 3.5[3.0; 3.5] (p=0.043). We observed two clinical relapses during the study period: one in an AQP4-IgG+ male and another one in a MOG-IgG+ woman. There was a significant decrease in the annualized relapse rate in all groups. The disability indicator did not increase during the study period, and in AQP4-IgG and MOG-IgG seronegative patients, it slightly but significantly decreased. Brain and spinal cord MRI monitoring during the treatment period revealed new active foci only in two patients with clinical relapses.Conclusion. RTX treatment in NMOSDs is reasonably efficient and safe, but with the obligatory prior patient evaluation and monitoring of treatment results.

Intravenous infusion of grape sugar with neosalvarsan for syphilis

Eugen (Derm. Woch., 1923, No. 36) used in a number of cases of syphilis intravenous infusions of solutions of grape sugar with neosalvarsan (20 cubic site. 50% sugar solution and 0.15-0.3 neosalvarsan).

Rivanol for childbirth fever

Having tried intravenous infusions of 0.1% rivanol solution (Rivanoli 0.1, saccliari 0.3, aqd dest.ad 100.0, the solution is sterilized by boiling), Bock (Deut.l med. Wocli., 1921, No. 11; according to ref . in "Practice. Vr.", 1924, No. 7-8 received such brilliant, sometimes downright incredible results that he considers it a very foamy remedy for the fight against postpartum septicemia