Trichotillomania in an Autistic Spectum Disroder: Single Case Intervention

The following work addresses trichotillomania and dermatillomania, both symptoms of the impulses control, in a 11 years old girl, who courses the sixth grade in a private elementary school and with a diagnose of first degree autism spectrum disorder and Attention Deficit Hyperactivity Disorder (ADHD) as a comorbidity. The objective was to reduce the frequency of tearing her hair and the skin imperfections in the school context throughout an intervention based on cognitive behavioral techniques. Within the used methodology to analyze the case an exhaustive evaluation of the patient has been performed using grade observation records, before and during the intervention period in order to systematize the whole process. The intervention techniques used where Token Economy and self-instruction. The results show a progressive improvement of the symptoms, reflected in the diminish of frequency of the behaviors registered that were conducted. In spite of the limited time for the intervention for these kinds of behaviors and the base line phase, it was possible to get to know the girl well and establish bonds with her, in spite of her condition, which can be noted in a better adaptation on her school context. This work seeks to favor the increase of research on this disorder since there is information related on the etiological factors, but it still is not enough, likewise, the related information on these disorders and its possible comorbidities is useful to continue with the advance on the treatments in this area.

First Successful Proppant Frac in a Water Injection Field Strategy, West Qurna-1, South Iraq

Zubair formation in West Qurna field, is one of the largest prolific reservoirs comprising of oil bearing sandstone layers interbedded with shale sequences. An average productivity index of 6 STB/D/psi is observed without any types of stimulation treatment. As the reservoir pressure declines from production, a peripheral water injection strategy was planned in both flanks of the reservoir to enhance the existing wells production deliverability. The peripheral injection program was initiated by drilling several injectors in the west flank. Well A1 was the first injector drilled and its reservoir pressure indicated good communication with the up-dip production wells. An injection test was conducted, revealing an estimated injectivity index of 0.06 STB//D/psi. Candidate well was then re-perforated and stimulated with HF/HCl mud acid, however no significant improvement in injectivity was observed due to the complex reservoir mineralogy and heterogeneity associated to the different targeted layers. An extended high-pressure injection test was performed achieving an injectivity index of 0.29 STB/D/psi at 4500 psi. As this performance was sub-optimal, a proppant fracture was proposed to achieve an optimal injection rate. A reservoir-centric fracture model was built, using the petrophysical and geo-mechanical properties from the Zubair formation, with the objective of optimizing the perforation cluster, fracture placement and injectivity performance. A wellhead isolation tool was utilized as wellhead rating was not able to withstand the fracture model surface pressure; downhole gauges were also installed to provide an accurate analysis of the pressure trends. The job commenced with a brine injection test to determine the base-line injectivity profile. The tubing volume was then displaced with a linear gel to perform a step-rate / step-down test. The analysis of the step-rate test revealed the fracture extension pressure, which was set as the maximum allowable injection pressure when the well is put on continuous injection. The step-down test showed significant near wellbore tortuosity with negligible perforation friction. A fracture fluid calibration test was then performed to validate the integrated model leak-off profile, fracture gradient and young’s modulus; via a coupled pressure fall-off and temperature log analysis. Based on the fluid efficiency, the pad volume was adjusted to achieve a tip screen-out. The job was successfully pumped and tip screen-out was achieved after pumping over ~90% of the planned proppant volume. A 7 days post-frac extended injection test was then conducted, achieving an injection rate of 12.5 KBWD at 1300 psi with an injectivity index of 4.2 STB/D/psi. These results proved that the implementation of a reservoir-centric Proppant Fracture treatment, can drastically improve the water injection strategy and field deliverability performance even in good quality rock formations. This first integrated fracture model and water injection field strategy, represents a building platform for further field development optimization plans in Southern Iraq.

Effect of autologous platelet rich plasma on anti-mullerian hormone and antral follicle count in sub fertile women with poor ovarian reserve

Background: Ovarian aging may be reversible. Platelet rich plasma (PRP) has growth factors that promote cellular proliferation and folliculogenesis. Recently published studies and case reports suggest that ovarian rejuvenation can be done by PRP treatment. The objective of the study was to evaluate the effect of platelet rich plasma on ovarian reserve markers such as anti mullerian hormone (AMH) and antral follicle count (AFC) in sub fertile women with poor ovarian reserve (POR).Methods: The self-controlled quasi experimental study was carried out on 29 sub fertile women with poor ovarian reserve. They were selected for laparoscopic tubo-peritoneal evaluation as they could not afford in vitro fertilization. During laparoscopy, 5 ml of pre prepared autologous PRP was injected into each ovary. Post-PRP AMH and AFC were measured at every cycle for a period of at least three (3) months and compared with base line values.Results: Mean age of participants was 35.9±3.2 years. Baseline AMH was 0.31±0.17 ng/ml and baseline AFC was 3.41±0.73. AMH was raised on first, second and third cycle from base line values in 58.62%, 86.21% and 91.30% of the study population respectively. AMH changes in all three cycle were statistically significant. Pregnancy occurred in three (10.34%) women during the study period.Conclusions: The injection of autologous PRP into human ovaries is a safe procedure to improve ovarian reserve markers (AMH and AFC) in women with POR.

The effect of Cisplatin on Complete blood count among chemotherapy Sudanese patients at Taiba Cancers Center in Khartoum state 2021

Background: Cisplatin is one of therapy used as anticancer activity in a variety of tumors. Among many chemotherapy drugs that are widely used for cancer, Cisplatin is one of the most compelling ones. Material and methods: This study was Analytical cross sectional study conducted at Taiba Cancer Center, Khartoum, Sudan, during the period July 2021 to November 2021 and aimed to estimate the complete blood count among chemotherapy Sudanese patients treated with Cisplatin. 50 cancer patients treated with cisplatin as chemotherapy selected as a case group and 50 apparently health donor were selected as control group. Three ml of the venous blood was collected in EDTA container. Six sample collected from each patient before each dose of cisplatin. Complete blood count was done by using Sysmex Automated Hematology Analyzer KX 21N.Result: When compared the base line of case value of RBCs, Hb, WBCs, neutrophils, and platelets with control there were insignificant differences (P. value ≥ 0.05). But when compared RBCs, Hb, WBCs, neutrophils, and platelets between the case (baseline) and the cases in cycle 1, 2,3,4 and 5 there was significant decreased among progression of doses (P. value ≤ 0.05). There was insignificant correlation in the duration of the cancer and WBCs, neutrophil count, HGB and platelets count (P. value ≥ 0.05), significant correlation with RBCs in baseline and cycle 2 (P. value < 0.05). When correlate the anatomical location of cancer with WBCs, neutrophil count there was insignificant correlation, and significant correlation with RBC and HGB in cycle 5 and platelets count cycle 2 and cycle 3 Conclusion: The study observed that Cisplatin with combination of drug can effect on the hematological parameters also the chemotherapy was induced anemia, neutropenia and thrombocytopenia.

MONITORAMENTO DE FALHAS EM SISTEMAS DINÂMICOS UTILIZANDO UM MÉTODO DE ANÁLISE DE DADOS BASEADO NO ALGORITMO DE SELEÇÃO NEGATIVA

This work presents the application of a method for monitoring and diagnosing failures in mechanical structures based on the theory of vibration signals and on Artificial Immune Systems to assist in data processing. It uses the Negative Selection Algorithm as a tool to identify fault samples extracted from the laboratory simulated signals of a dynamic rotor. This methodology can help mechanical structure maintenance professionals, facilitating decision-making. The data set used in the processing of the intelligent system was generated through experiments. For normal (base-line) conditions, the signals of the rotor in free operation were used, that is, without the addition of unbalance mass, and for the fault conditions, unbalance masses were added to the system. The results are satisfactory, showing precision and robustness.

Assess Digital Maturity to Set Digital Transformation Strategy in Oil and Gas

This paper presents a structured methodology for an oil company to embark on a digital transformation. It was implemented in several JVs with a NOC that includes three producing blocks with dozens of mature fields. The methodology has several key unique strengths: One is the ability to isolate the core-money-making processes and build a digital strategy around them. This shows early gains and at the same time becomes a buy-in support for management. Another advantage is the simplicity to define the "desired" digital maturity level using direct input from the final stakeholders. This is achieved by using the process enhancement method, a SIPOC technique (Supplier, Input, Process, Output, Customer analysis). Also, an important strength is the methodology does not ignore the existing IT infrastructure, nor the field systems (i.e., SCADA) and re-uses them, as much as possible, giving enough time for a transition or an upgrade when needed. Several tools are provided in this paper that makes the methodology consistent, auditable, and strong to support the designed digital strategy to any management level with high chance of approval. The methodology is flexible enough to be run on various types of contracts, hydrocarbon phase or operational environments. As with any method, it relies on commitment from the top and base line in the organization, requiring open and honest evaluation of current inefficiencies and, equally important, resources (budget and people). In summary, a digital transformation is not a sudden leap from a company's current analog status to an instantaneous digital state of being. Rather, it is a progressive, step-by-step transition of core processes and user-centric workflows that requires careful planning and a thoughtful methodology to find the most suitable scenario for each company.

High Definition Acoustic and Temperature Logging for the Diagnosis of Complex Annuli Leaks and Communication

Maintaining annuli integrity is critical for safe and optimized well operations. Monitoring of tubing casing annulus (TCA) and casing-casing annulus (CCA) pressures is mandatory as it gives a direct indication of possible seal or tubular failures that may lead to a negative impact on HSE or well production. In cases where the observed annuli pressures suggest leaks and possible communication between tubing and TCA or TCA and CCA, a comprehensive plan should be put in place to detect and evaluate the possible leak sources and paths that will allow for proper remedial actions. Logging techniques using spectral noise logging (SNL), and high precision temperature Logging (HPT) are one way to diagnose the source of a leak and communication path between 2 adjacent casings (for example TCA and CCA). The operation is performed by running the HPT and SNL log under shut in conditions to establish a base line, followed by logging under dynamic conditions. Dynamic conditions can include bleeding off the TCA pressure while all other annuli and tree valves are shut-in and injecting into the tubing-casing annulus while bleeding off the CCA. The dynamic passes aim to activate the leak points. The SNL and HPT will capture the corresponding temperature and Spectral noise events revealed by the fluid flow though the leak points. These are compared to the base line shut in logs. The SNL is run in stations and can capture noise generated by fluid movement in a wide range of strength (decibels) and frequency within a wide scanning radius, while HPT can capture minor temperature changes of 0.02 Deg F. The paper will discuss an example where the HPT and SNL were run along with a set of conventional sensors such as GR, CCL, and pressure in a HPHT gas well to diagnose leak points and a possible communication path between the TCA and CCA. The Logging operation was carried out rig-less with minimum intervention using wire line under the shut in and dynamic conditions. Spectral noise logging precisely captured the leak points and drew a clear picture of the casing integrity breaches in multiple points. The results of the diagnostics and evaluation will now be used to design the appropriate remedial actions required to restore the well to the desired condition for production.

The Effect of Isotonic Saline Nasal Lavages in Improving Symptoms in SARS-CoV-2 Infection: A Case-Control Study

Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mainly colonizes nasopharynx. In upper airways acute infections, e.g., the common cold, saline nasal irrigations have a significant efficacy in reducing symptoms. The present study aimed to test the efficacy of nasal lavages in upper airways symptoms of Coronavirus Disease 2019 (COVID-19).Methods: A series of consecutive adult subjects who tested positive for SARS-CoV-2 from December 2020 to February 2021 performed daily nasal lavages with saline solution (Lavonase®—Purling, Lugo di Romagna, Italy) for 12 days, starting on the day after the SARS-CoV-2 positive swab. A control group included a historical series of patients who were infected in February-March 2020 and who did not perform lavages. An ad hoc questionnaire regarding symptoms was administered to each subjects at base-line and 10 days after diagnosis (i.e., on the same day of the control swab) in both cases and controls.Results: A total of 140 subjects were enrolled. 68 participants in the treatment group and 72 in the control group were included. 90% of respondents declared the lavages were simple to use and 70% declared they were satisfied. Symptoms of blocked nose, runny nose, or sneezing decreased by an average of 24.7% after the treatment. Blocked nose and sneezing increased in the same period of time in the control group. Ears and eyes symptoms, anosmia/ageusia symptoms, and infection duration (10.53 days in the treatment group and 10.48 days in the control group) didn't vary significantly among the two groups.Conclusion: Nasal lavages resulted to significantly decrease nasal symptoms in newly diagnosed SARS-CoV-2 patients. These devices proved to be well-tolerated and easy to be used. Further studies on a larger number of subjects are needed in order to possibly confirm these preliminary results.

Study on Population Dynamics and Effects of Inbreeding on Performance Traits in Indian Murrah Buffalo

Background: A population is continuously facing the changing environment and its directly influencing the production of animal so to adopt these changes population must be flexible and have sufficient variability to overcome the adverse affects of environment. The evaluation of animals in terms of production performance traits along with impact of inbreeding coefficient is essential to formulate breeding and selection strategies for higher genetic improvement. Methods: Genealogy data of 6429 animals maintained at ICAR-NDRI, Karnal, India was analyzed by web-based POPREP application tool (http:// poprep.tzv.fal.de) and ENDOG V5.8 used to study the population structure and genetic diversity and regression model to study the effect of inbreeding on first lactation productive traits in Murrah buffaloes. Result: The result indicated that 91.91% of the individuals had known pedigree. The maximum generation traced was 13 with mean, full and equivalent complete generation as 5.93, 1.67 and 3.25 respectively. The average generation interval was 8.28 years and longer for the sire-son pathway and 2.16% was average inbreeding in whole population. The average genetic diversity loss was 2.10% indicated that the population has been stable with sufficient diversity. The study also revealed non significant effect of inbreeding on all first lactation traits. The low inbreeding was firstly due to introduction of new genetic variant and culling of animals avoiding mating of related ones and secondly due to incompleteness of pedigree in earlier years. This can be used as a base line information of phenomic needs to be generated before applying genomics tools in particular herd to be used as reference population in future for genomic selection.

A Comparative Evaluation between the Efficacy of Scaling & Root Planing (SRP) with Local Delivery of Chlorhexidine Gluconate and SRP Alone in Periodontal Pocket Reduction Therapy

Aim: The aim of the present study was to compare the efficacy of locally delivered chlorhexidine as an adjunct to scaling and root planning (SRP) & SRP alone in bringing reduction of pocket depth in the treatment of moderate to severe periodontitis patients. Materials and Methods: A total number of 15 patients both males and females in the age group of 30-55 years were selected with total number of 30 sites with periodontal probing pocket depth measuring 5-8mm in different quadrant of the mouth. A randomized, double blind, controlled clinical trial design was followed for the study. On one side scaling and root planning was done and on the other side scaling and root planning was done along with local delivery of chlorhexidine glugocate then the patient was examined after 0, 45, and 60 days using The clinical parameters the Plaque Index (PI), gingival index (GI), Bleeding on probing (BOP), Clinical attachment level (CAL) and Probing pocket depth (PPD). Statistical Analysis: Student paired T-test has been carried out for this present study. Results: The mean reduction of Plaque Index score between 0-45 day between control site and test site was 1.58±0.11 and the mean reduction of Plaque Index score between 0-60 day between control site and test site was 2.42±0.34 which is found not significant. At the Control site the mean plaque index score on 0 day was 2.2, on 45th day was 1.88 and on 60th day was 1.82. At the test site the mean plaque index score on 0 day was 2.6, on 45th day was 1.82 and on 60thday was 1.59. There was change from the base line values of mean plaque index between the control sites and test sites but was not significant. Conclusion: There was improvement in all the clinical parameters of the test sites in comparison to the control sites from base line to 60 days, but the adjunctive use of chlorhexidine showed a significant improvement only on the clinical attachment level.