Changes in translation of synaptic excitation to dentate granule cell discharge accompanying long-term potentiation. I. Differences between normal and reinnervated dentate gyrus.

1981 ◽  
Vol 46 (2) ◽  
pp. 324-338 ◽  
Author(s):  
R C Wilson
Keyword(s):  
Dentate Gyrus ◽  
Granule Cell ◽  
Long Term Potentiation ◽  
Dentate Granule Cell ◽  
Synaptic Excitation ◽  
Cell Discharge ◽  
Term Potentiation

scholarly journals A voltage-based metaplasticity rule applied to the model hippocampal granule cell accounts for homeostatic heterosynaptic plasticity

2019 ◽  
Author(s):  
Azam Shirrafiardekani ◽  
Lubica Benuskova ◽  
Jörg Frauendiener
Keyword(s):  
Spontaneous Activity ◽  
Granule Cell ◽  
Long Term Potentiation ◽  
Homeostatic Plasticity ◽  
Perforant Path ◽  
Dentate Granule Cell ◽  
Reduced Frequency ◽  
Term Potentiation

AbstractLong-term potentiation (LTP) and long-term depression (LTD) of synaptic efficacies are involved in establishment of long-term memories. In this process, neurons need to adjust the overall efficacy of their synapses by using mechanisms of homeostatic plasticity to balance their activity and control their firing rate. For instance, in the dentate granule cell in vivo, induction of homosynaptic LTP in the tetanized medial perforant path is accompanied by heterosynaptic LTD in the non-tetanized lateral perforant path. We used the compartmental model of this cell to test the following hypotheses: 1. Using plasticity and metaplasticity rules both based on postsynaptic voltage we can reproduce homosynaptic LTP and concurrent heterosynaptic LTD, provided there is an ongoing noisy spontaneous activity; 2. Frequency of an ongoing noisy spontaneous activity along the lateral path determines the magnitude of heterosynaptic LTD. In experiments where procaine was used to block the lateral spontaneous activity, no heterosynaptic LTD occurred. However, when the procaine was washed out and a second tetanization was applied to the medial path, no heterosynaptic LTD could have been induced neither. Our simulations predict that the reduced frequency of spontaneous activity in the lateral perforant path can account for this lasting absence of heterosynaptic LTD.

scholarly journals Dentate gyrus granule cell firing patterns can induce mossy fiber long-term potentiation in vitro

Hippocampus ◽  
2010 ◽  
Vol 21 (11) ◽  
pp. 1157-1168 ◽  
Author(s):  
Rajen Mistry ◽  
Siobhan Dennis ◽  
Matthew Frerking ◽  
Jack R. Mellor
Keyword(s):  
Dentate Gyrus ◽  
Granule Cell ◽  
Mossy Fiber ◽  
Long Term Potentiation ◽  
Firing Patterns ◽  
Term Potentiation ◽  
Cell Firing

Spine formation pattern of new neurons is modulated by induction of long-term potentiation (LTP) in adult dentate gyrus

2009 ◽  
Vol 65 ◽  
pp. S83
Author(s):  
Noriaki Ohkawa ◽  
Yoshito Saitoh ◽  
Eri Tokunaga ◽  
Toshio Kitamura ◽  
Kaoru Inokuchi
Keyword(s):  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Spine Formation ◽  
Term Potentiation ◽  
Formation Pattern

Spatial performance correlates with long-term potentiation of the dentate gyrus but not of the CA1 region in rats with fimbria–fornix lesions

2001 ◽  
Vol 307 (3) ◽  
pp. 159-162 ◽  
Author(s):  
Kazuhito Nakao ◽  
Yuji Ikegaya ◽  
Maki K Yamada ◽  
Nobuyoshi Nishiyama ◽  
Norio Matsuki
Keyword(s):  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Ca1 Region ◽  
Term Potentiation ◽  
Spatial Performance
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