scholarly journals A voltage-based metaplasticity rule applied to the model hippocampal granule cell accounts for homeostatic heterosynaptic plasticity

2019 ◽  
Author(s):  
Azam Shirrafiardekani ◽  
Lubica Benuskova ◽  
Jörg Frauendiener
Keyword(s):  
Spontaneous Activity ◽  
Granule Cell ◽  
Long Term Potentiation ◽  
Homeostatic Plasticity ◽  
Perforant Path ◽  
Dentate Granule Cell ◽  
Reduced Frequency ◽  
Term Potentiation

AbstractLong-term potentiation (LTP) and long-term depression (LTD) of synaptic efficacies are involved in establishment of long-term memories. In this process, neurons need to adjust the overall efficacy of their synapses by using mechanisms of homeostatic plasticity to balance their activity and control their firing rate. For instance, in the dentate granule cell in vivo, induction of homosynaptic LTP in the tetanized medial perforant path is accompanied by heterosynaptic LTD in the non-tetanized lateral perforant path. We used the compartmental model of this cell to test the following hypotheses: 1. Using plasticity and metaplasticity rules both based on postsynaptic voltage we can reproduce homosynaptic LTP and concurrent heterosynaptic LTD, provided there is an ongoing noisy spontaneous activity; 2. Frequency of an ongoing noisy spontaneous activity along the lateral path determines the magnitude of heterosynaptic LTD. In experiments where procaine was used to block the lateral spontaneous activity, no heterosynaptic LTD occurred. However, when the procaine was washed out and a second tetanization was applied to the medial path, no heterosynaptic LTD could have been induced neither. Our simulations predict that the reduced frequency of spontaneous activity in the lateral perforant path can account for this lasting absence of heterosynaptic LTD.

scholarly journals Neuroligin-3 Regulates Excitatory Synaptic Transmission and EPSP-Spike Coupling in the Dentate Gyrus In Vivo

2021 ◽  
Author(s):  
Julia Muellerleile ◽  
Matej Vnencak ◽  
Angelo Ippolito ◽  
Dilja Krueger-Burg ◽  
Tassilo Jungenitz ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Autism Spectrum ◽  
Perforant Path ◽  
Adhesion Protein ◽  
Neuronal Excitation ◽  
Term Potentiation

Abstract Neuroligin-3 (Nlgn3), a neuronal adhesion protein implicated in autism spectrum disorder (ASD), is expressed at excitatory and inhibitory postsynapses and hence may regulate neuronal excitation/inhibition balance. To test this hypothesis, we recorded field excitatory postsynaptic potentials (fEPSPs) in the dentate gyrus of Nlgn3 knockout (KO) and wild-type mice. Synaptic transmission evoked by perforant path stimulation was reduced in KO mice, but coupling of the fEPSP to the population spike was increased, suggesting a compensatory change in granule cell excitability. These findings closely resemble those in neuroligin-1 (Nlgn1) KO mice and could be partially explained by the reduction in Nlgn1 levels we observed in hippocampal synaptosomes from Nlgn3 KO mice. However, unlike Nlgn1, Nlgn3 is not necessary for long-term potentiation. We conclude that while Nlgn1 and Nlgn3 have distinct functions, both are required for intact synaptic transmission in the mouse dentate gyrus. Our results indicate that interactions between neuroligins may play an important role in regulating synaptic transmission and that ASD-related neuroligin mutations may also affect the synaptic availability of other neuroligins.

Oleuropein Improves Long Term Potentiation at Perforant Path-dentate Gyrus Synapses in vivo

2015 ◽  
Vol 7 (3) ◽  
pp. 255-260 ◽  
Author(s):  
Fei-fei Pu ◽  
Song Yin ◽  
Hong-ying Chen ◽  
Zhi Dai ◽  
Tian-xiu Qian ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Perforant Path ◽  
Term Potentiation

Brain RNA synthesis, long-term potentiation and depression at the perforant path-granule cell synapse in the guinea pig

1995 ◽  
Vol 36 (6) ◽  
pp. 515-526 ◽  
Author(s):  
A.G. Sadile ◽  
A. Neugebauer ◽  
T. Gessi ◽  
S. Marchionni ◽  
A. Giuditta
Keyword(s):  
Guinea Pig ◽  
Granule Cell ◽  
Rna Synthesis ◽  
Long Term Potentiation ◽  
Perforant Path ◽  
Term Potentiation ◽  
Cell Synapse

In Vivo Recordings of Long-Term Potentiation and Long-Term Depression in the Dentate Gyrus of the Neonatal Rat

2004 ◽  
Vol 91 (2) ◽  
pp. 613-622 ◽  
Author(s):  
Michael P. O'Boyle ◽  
Viet Do ◽  
Brian E. Derrick ◽  
Brenda J. Claiborne
Keyword(s):  
Dentate Gyrus ◽  
Granule Cells ◽  
Long Term Potentiation ◽  
Neonatal Rat ◽  
Perforant Path ◽  
Long Term Depression ◽  
Term Potentiation ◽  
Old Rats

Previous in vitro studies demonstrated that long-term potentiation (LTP) could be elicited at medial perforant path (MPP) synapses onto hippocampal granule cells in slices from 7-day-old rats. In contrast, in vivo studies suggested that LTP at perforant path synapses could not be induced until at least days 9 or 10 and then in only a small percentage of animals. Because several characteristics of the oldest granule cells are adult-like on day 7, we re-examined the possibility of eliciting LTP in 7-day-old rats in vivo. We also recorded from 8- and 9-day-old rats to further elucidate the occurrence and magnitude of LTP in neonates. With halothane anesthesia, all animals in each age group exhibited synaptic plasticity of the excitatory postsynaptic potential following high-frequency stimulation of the MPP. In 7-day-old rats, LTP was elicited in 40% of the animals and had an average magnitude of 143%. Long-term depression (LTD) alone (magnitude of 84%) was induced in 40% of the animals, while short-term potentiation (STP) alone (magnitude of 123%) was induced in 10%. STP followed by LTD was elicited in the remaining 10%. Data were similar for all ages combined. In addition, the N-methyl-d-aspartate (NMDA) antagonist ( R,S)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) blocked the occurrence of LTP at each age and doubled the percentage of animals expressing LTD alone for all ages combined. These results demonstrate that tetanic stimulation can elicit LTP or LTD at MPP synapses in 7-day-old rats, supporting our premise that at least a portion of the dentate gyrus is functional at this early age.

Rapidly induced gene networks following induction of long-term potentiation at perforant path synapses in vivo

Hippocampus ◽  
2011 ◽  
Vol 21 (5) ◽  
pp. 541-553 ◽  
Author(s):  
Margaret M. Ryan ◽  
Sara E. Mason-Parker ◽  
Warren P. Tate ◽  
Wickliffe C. Abraham ◽  
Joanna M. Williams
Keyword(s):  
Gene Networks ◽  
Long Term Potentiation ◽  
Perforant Path ◽  
Term Potentiation
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