scholarly journals Effects of Gray-Scale Ultrasonography Immediate Post-Contrast on Characterization of Focal Liver Lesions

2015 ◽  
Vol 2015 ◽  
pp. 1-11
Author(s):  
Wei Yang ◽  
Min-Hua Chen ◽  
Wei Wu ◽  
Ying Dai ◽  
Zhi-Hui Fan
Keyword(s):  
Interventional Procedure ◽  
Hepatic Metastases ◽  
Focal Liver Lesions ◽  
Imaging Features ◽  
Liver Lesions ◽  
Gray Scale ◽  
Post Contrast ◽  
Contrast Enhanced ◽  
Before And After

This study compared the imaging features of conventional gray scale ultrasound (US) before and after contrast-enhanced ultrasound (CEUS) for focal liver lesions and 22 evaluated the role of US post-CEUS in characterizing liver lesions. 126 patients with 158 focal liver lesions underwent CEUS and US post-CEUS examination and entered this study. There were 74 hepatocellular carcinomas (HCC), 43 hepatic metastases, and 41 hemangiomas. Imaging features of US pre-CEUS and US post-CEUS were analyzed offsite by two blinded experienced radiologists to evaluate size, boundary, echogenicity, internal texture, posterior acoustic enhancement, spatial resolution, and contrast resolution. In the end with pathological and clinical evidence, the diagnostic accuracy rate of US pre-CEUS was 53.8% (85/158 lesions), lower than that of CEUS (88.0%, 139/158 lesions); with the complementation of US post-CEUS the rate rose to 93.0% (147/158 lesions). US post-CEUS could improve the visibility of typical structures of focal liver lesions and might provide important complementary information for CEUS diagnosis. It also increases the visibility of small liver lesions compared with US pre-CEUS and helps to guide local interventional procedure.

Differential diagnosis of focal liver lesions: role of spin-echo and contrast-enhanced dynamic MR imaging.

Radiology ◽  
1994 ◽  
Vol 193 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Y Yamashita ◽  
Y Hatanaka ◽  
H Yamamoto ◽  
A Arakawa ◽  
T Matsukawa ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Mr Imaging ◽  
Spin Echo ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Dynamic Mr Imaging ◽  
Contrast Enhanced ◽  
Dynamic Mr

scholarly journals Role of contrast enhanced ultrasound in characterization of focal liver lesions

2014 ◽  
Vol 45 (1) ◽  
pp. 7-17 ◽  
Author(s):  
Shruti Thakur ◽  
Anupam Jhobta ◽  
D.S. Dhiman ◽  
R.G. Sood ◽  
Arun Chauhan ◽  
...  
Keyword(s):  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced

The Role of Contrast-Enhanced Sonography of Focal Liver Lesions Before Percutaneous Biopsy

2006 ◽  
Vol 187 (3) ◽  
pp. 752-761 ◽  
Author(s):  
Wei Wu ◽  
Min-Hua Chen ◽  
Shan-Shan Yin ◽  
Kun Yan ◽  
Zhi-Hui Fan ◽  
...  
Keyword(s):  
Percutaneous Biopsy ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Contrast Enhanced

The role of contrast-enhanced ultrasound in the characterisation of focal liver lesions

2008 ◽  
Vol 29 (S 1) ◽  
Author(s):  
DL Sandulescu ◽  
A Saftoiu ◽  
I Rogoveanu ◽  
T Ciurea ◽  
DI Gheonea ◽  
...  
Keyword(s):  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced

Characterization of Malignant Focal Liver Lesions with Contrast-Enhanced 40 MHz Ultrasound Imaging in Hepatitis B Virus X Transgenic Mice: A Feasibility Study

2008 ◽  
Vol 30 (4) ◽  
pp. 203-216 ◽  
Author(s):  
Ai-Ho Liao ◽  
Ya-Chien Cheng ◽  
Chien-Hsiu Weng ◽  
Ting-Fen Tsai ◽  
Wei-Hsiang Lin ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Liver Parenchyma ◽  
Liver Lesion ◽  
Focal Liver Lesion ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Preclinical Research ◽  
Post Contrast ◽  
Contrast Enhanced ◽  
B Virus

Contrast-enhanced ultrasound (CEUS) imaging has been a reliable clinical method of detecting three vascular contrast phases and characterizing focal liver lesions. Previous results were all from human (i.e., clinical studies). The main purpose of this study was to extend this to small animals and to investigate the feasibility of using CEUS in preclinical research. Specifically, high-frequency (40 MHz) ultrasound liver imaging with albumin-shelled microbubbles was employed to detect the three vascular contrast phases and characterize focal liver lesions that developed in thirteen Hepatitis B virus X (HBx) transgenic mice at around 14 to 16 months of age. Previous studies indicated that 90–100% incidence of hepatocellular carcinoma (HCC) was observed in HBx transgenic male mice. After injecting the contrast agent, the time-intensity curves (TICs) of focal liver lesions, vessels in focal liver lesions and surrounding liver parenchyma tissues were measured for 30 minutes. The peak of mean intensity relative to the baseline increased 7.36 dB (p<0.02). On the other hand, the mean contrast between the focal liver lesion and the liver parenchyma increased by 7.74 (p<0.05) dB, thus allowing clear detection of the lesion margin. Histopathology investigations confirmed the development of the lesion in these mice. In addition, guidelines of European Federation of Societies for Ultrasound in Medicine and Biology were followed as an attempt to characterize features of the TICs in mice. The arterial phase was defined as 2 to 60 seconds post contrast injection, and the parenchyma phase was defined as the time period from 10 to 30 minutes post contrast injection. Comparing the imaging with the pathology results, the sensitivity, specificity and accuracy of CEUS for the detection of malignant focal liver lesion in HBx transgenic mice were 91%, 100% and 92%. These results demonstrated that high-frequency CEUS imaging potentially can be used for detecting the three vascular contrast phases of malignant focal liver lesions and characterizing malignant focal liver lesions in mice. Thus can be a valuable tool in preclinical research.

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