Safety, Pharmacokinetics, and Pharmacodynamics of AMG 102, a Fully Human Hepatocyte Growth Factor–Neutralizing Monoclonal Antibody, in a First-in-Human Study of Patients with Advanced Solid Tumors

Solid Tumors ◽

Human Study ◽

Advanced Solid Tumors ◽

Pharmacokinetics And Pharmacodynamics ◽

Neutralizing Monoclonal Antibody ◽

Pharmacodynamic (PD) – Pharmacokinetic (PK) Study of Ficlatuzumab(F), A Monoclonal Antibody (MAB) Directed to the Hepatocyte Growth Factor (HGF), in Patients (PTS) with Advanced Solid Tumors who have Liver Metastases (METS)

Annals of Oncology ◽

10.1016/s0923-7534(20)33049-0 ◽

2012 ◽

Vol 23 ◽

pp. ix154 ◽

Cited By ~ 1

Author(s):

E. Elez ◽

J. Tabernero ◽

L. Prudkin ◽

S. Agarwal ◽

M. Han ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Liver Metastases ◽

Solid Tumors ◽

Advanced Solid Tumors ◽

Phase I study of SCH 900105 (SC), an anti-hepatocyte growth factor (HGF) monoclonal antibody (MAb), as a single agent and in combination with erlotinib (E) in patients (pts) with advanced solid tumors.

Journal of Clinical Oncology ◽

10.1200/jco.2010.28.15_suppl.2525 ◽

2010 ◽

Vol 28 (15_suppl) ◽

pp. 2525-2525 ◽

Cited By ~ 14

Author(s):

A. Patnaik ◽

G. J. Weiss ◽

K. Papadopoulos ◽

R. Tibes ◽

A. W. Tolcher ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Phase I ◽

Solid Tumors ◽

Phase I Study ◽

Single Agent ◽

Advanced Solid Tumors ◽

Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-07-2169 ◽

2008 ◽

Vol 7 (7) ◽

pp. 1913-1922 ◽

Cited By ~ 29

Author(s):

Laura P. Stabile ◽

Mary E. Rothstein ◽

Phouthone Keohavong ◽

Jide Jin ◽

Jinling Yin ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Human Hepatocyte ◽

Lung Tumorigenesis ◽

Therapeutic Targeting ◽

Neutralizing Monoclonal Antibody ◽

Immunohistochemical application of a highly sensitive and specific murine monoclonal antibody recognising the extracellular domain of the human hepatocyte growth factor receptor ( MET )

Histopathology ◽

10.1111/his.12510 ◽

2014 ◽

Vol 65 (6) ◽

pp. 879-896 ◽

Cited By ~ 13

Author(s):

Aaron M Gruver ◽

Ling Liu ◽

Peter Vaillancourt ◽

Sau‐Chi B Yan ◽

Joel D Cook ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Growth Factor Receptor ◽

Extracellular Domain ◽

Human Hepatocyte ◽

Hepatocyte Growth Factor Receptor ◽

Highly Sensitive ◽

Pharmacokinetics and Pharmacodynamics following Intravenous Administration of Recombinant Human Hepatocyte Growth Factor in Rats with Renal Injury

Pharmacology ◽

10.1159/000363412 ◽

2014 ◽

Vol 94 (3-4) ◽

pp. 190-197 ◽

Cited By ~ 5

Author(s):

Eri Adachi ◽

Tomoko Hirose-Sugiura ◽

Yukio Kato ◽

Fumie Ikebuchi ◽

Atsuko Yamashita ◽

...

Keyword(s):

Growth Factor ◽

Intravenous Administration ◽

Renal Injury ◽

Human Hepatocyte ◽

Pharmacokinetics And Pharmacodynamics ◽

Abstract A100: A phase 1, first in human, study of SCH 900105, an antihepatocyte growth factor (HGF) monoclonal antibody, in subjects with advanced solid tumors

10.1158/1535-7163.targ-09-a100 ◽

2009 ◽

Cited By ~ 3

Author(s):

Ramesh K. Ramanathan ◽

Francis C. Payumo ◽

Kyriakos P. Papadopoulos ◽

Glen J. Weiss ◽

Glenda Chambers ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Solid Tumors ◽

Phase 1 ◽

Human Study ◽

Advanced Solid Tumors

Evaluation of the effect of static magnetic fields combined with human hepatocyte growth factor on human satellite cell cultures

Molecular Medicine Reports ◽

10.3892/mmr.2014.2083 ◽

2014 ◽

Vol 9 (6) ◽

pp. 2328-2334 ◽

Cited By ~ 3

Author(s):

RICHARD BIRK ◽

ULRICH SOMMER ◽

ANNE FABER ◽

CHRISTOPH ADERHOLD ◽

JOHANNES D. SCHULZ ◽

...

Keyword(s):

Growth Factor ◽

Magnetic Fields ◽

Satellite Cell ◽

Cell Cultures ◽

Human Hepatocyte ◽

Static Magnetic Fields ◽

Molecular cloning and expression of human hepatocyte growth factor

Nature ◽

10.1038/342440a0 ◽

1989 ◽

Vol 342 (6248) ◽

pp. 440-443 ◽

Cited By ~ 1534

Author(s):

Toshikazu Nakamura ◽

Tsutomu Nishizawa ◽

Mitchio Hagiya ◽

Tatsuya Seki ◽

Manabu Shimonishi ◽

...

Keyword(s):

Growth Factor ◽

Molecular Cloning ◽

Human Hepatocyte ◽

Cloning And Expression ◽

Angiogenesis induced by human hepatocyte growth factor gene without nitric oxide synthesis in a rat ischemic hindlimb model

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(03)82394-x ◽

2003 ◽

Vol 41 (6) ◽

pp. 297-298

Author(s):

Makoto Ishizawa ◽

Koji Ohmori ◽

Takahisa Noma ◽

Teppei Tsuji ◽

Kazushi Murakami ◽

...

Keyword(s):

Nitric Oxide ◽

Growth Factor ◽

Human Hepatocyte ◽

Nitric Oxide Synthesis ◽

Factor Gene ◽

Growth Factor Gene ◽

Evaluation of interleukin-6, interleukin-10 and human hepatocyte growth factor as tumor markers for hepatocellular carcinoma

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2006.10.036 ◽

2007 ◽

Vol 33 (2) ◽

pp. 208-212 ◽

Cited By ~ 67

Author(s):

C.-Y. Hsia ◽

T.-I. Huo ◽

S.-Y. Chiang ◽

M.-F. Lu ◽

C.-L. Sun ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Growth Factor ◽

Tumor Markers ◽

Interleukin 6 ◽

Interleukin 10 ◽

Human Hepatocyte ◽