Abstract 1313: CPI-818: A selective inhibitor of interleukin-2-inducible T-cell kinase (ITK) that inhibits T-cell receptor signaling, promotes Th1 skewing, and achieves objective tumor responses when administered to dogs with T cell lymphomas

2019 ◽  
Author(s):  
James W. Janc ◽  
Craig M. Hill ◽  
Patrick P. Ng ◽  
Andrew N. Hoston ◽  
Antonett Madriaga ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Interleukin 2 ◽  
Cell Receptor ◽  
Selective Inhibitor ◽  
Receptor Signaling ◽  
T Cell Lymphomas ◽  
T Cell Receptor Signaling ◽  
Inducible T Cell Kinase ◽  
Cell Receptor Signaling

scholarly journals T-cell Receptor Signaling Activates an ITK/NF-κB/GATA-3 axis in T-cell Lymphomas Facilitating Resistance to Chemotherapy

2016 ◽  
Vol 23 (10) ◽  
pp. 2506-2515 ◽  
Author(s):  
Tianjiao Wang ◽  
Ye Lu ◽  
Avery Polk ◽  
Pinki Chowdhury ◽  
Carlos Murga Zamalloa ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Receptor Signaling ◽  
T Cell Lymphomas ◽  
T Cell Receptor Signaling ◽  
Cell Receptor Signaling ◽  
Resistance To Chemotherapy

scholarly journals Differential Expression of Interleukin-17A and -17F Is Coupled to T Cell Receptor Signaling via Inducible T Cell Kinase

Immunity ◽  
2009 ◽  
Vol 31 (4) ◽  
pp. 587-597 ◽  
Author(s):  
Julio Gomez-Rodriguez ◽  
Nisebita Sahu ◽  
Robin Handon ◽  
Todd S. Davidson ◽  
Stacie M. Anderson ◽  
...  
Keyword(s):  
T Cell ◽  
Differential Expression ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Receptor Signaling ◽  
Interleukin 17A ◽  
T Cell Receptor Signaling ◽  
Inducible T Cell Kinase ◽  
Cell Receptor Signaling
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