Protection against Herpetic Ocular Disease by Immunotherapy with Monoclonal Antibodies to Herpes simplex Virus Glycoproteins

Herpetic ocular disease never produces well-identifiable morphological aspects. It is expensive, complicated and slow to culture Herpes simplex virus. The validity of the fluorescent monoclonal antibodies test was investigated using corneal cells with or without a sure herpetic lesion. The tests, on 36 cases without sure herpetic lesions, were always negative, while of the 42 patients with a clinically ascertained herpetic lesion, 38 were positive (90.5%) and 4 negative (9.5%), two of these on account of inadeguate tissue preparations. Thus, this method can prove useful and reliable for diagnostic purposes.

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Passive immunization with monoclonal antibodies against herpes simplex virus glycoproteins protects mice against herpetic ocular disease

Current Eye Research ◽

10.3109/02713688709020086 ◽

1987 ◽

Vol 6 (1) ◽

pp. 173-177 ◽

Cited By ~ 25

Author(s):

Joseph F. Metcalf ◽

Junichi Koga ◽

Subhendra Chatterjee ◽

Richard J. Whitley

Keyword(s):

Monoclonal Antibodies ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Passive Immunization ◽

Ocular Disease ◽

Simplex Virus

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Faculty Opinions recommendation of Monoclonal antibodies and human sera directed to the secreted glycoprotein G of herpes simplex virus type 2 recognize type-specific antigenic determinants.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1003873.39455 ◽

2002 ◽

Author(s):

Rhoda Ashley Morrow

Keyword(s):

Monoclonal Antibodies ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Virus Type ◽

Herpes Simplex Virus Type ◽

Antigenic Determinants ◽

Glycoprotein G ◽

Human Sera ◽

Simplex Virus

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Structural properties and reactivity of N-terminal synthetic peptides of herpes simplex virus type 1 glycoprotein D by using antipeptide antibodies and group VII monoclonal antibodies.

Journal of Virology ◽

10.1128/jvi.61.11.3607-3611.1987 ◽

1987 ◽

Vol 61 (11) ◽

pp. 3607-3611 ◽

Cited By ~ 9

Author(s):

D L Bosch ◽

H J Geerligs ◽

W J Weijer ◽

M Feijlbrief ◽

G W Welling ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Structural Properties ◽

Virus Type ◽

Herpes Simplex Virus Type ◽

Synthetic Peptides ◽

Glycoprotein D ◽

Simplex Virus

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Identification and typing of herpes simplex virus types 1 and 2 by monoclonal antibodies, sensitivity to the drug (E)-5-(2-bromovinyl)-2′-deoxyuridine, and restriction endonuclease analysis of viral DNA

Journal of Medical Virology ◽

10.1002/jmv.1890150302 ◽

1985 ◽

Vol 15 (3) ◽

pp. 215-222 ◽

Cited By ~ 4

Author(s):

Daniel H. Zimmerman ◽

Francis K. Mundon ◽

Susan E. Croson ◽

Laraine S. Henchal ◽

John J. Docherty ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Restriction Endonuclease ◽

Restriction Endonuclease Analysis ◽

Viral Dna ◽

Simplex Virus ◽

Endonuclease Analysis

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Monoclonal Antibodies Specific for Herpes Simplex Virus Type 1 Mediate Antiviral Effects in Vitro and in Vivo

Hybridomas and Cellular Immortality ◽

10.1007/978-1-4615-9352-2_31 ◽

1983 ◽

pp. 293-293

Author(s):

James T. Rector ◽

Robert N. Lausch ◽

John E. Oakes

Keyword(s):

Monoclonal Antibodies ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Virus Type ◽

Herpes Simplex Virus Type ◽

Antiviral Effects ◽

Simplex Virus

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Herpes Simplex Virus Ocular Disease

Herpes Simplex Viruses ◽

10.1201/9780203711828-10 ◽

2017 ◽

pp. 239-274 ◽

Cited By ~ 1

Author(s):

Thomas J. Liesegang

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Ocular Disease ◽

Simplex Virus

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Detection and serotyping of herpes simplex virus in MRC-5 cells by use of centrifugation and monoclonal antibodies 16 h postinoculation.

Journal of Clinical Microbiology ◽

10.1128/jcm.21.1.29-32.1985 ◽

1985 ◽

Vol 21 (1) ◽

pp. 29-32 ◽

Cited By ~ 84

Author(s):

C A Gleaves ◽

D J Wilson ◽

A D Wold ◽

T F Smith

Keyword(s):

Monoclonal Antibodies ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Simplex Virus

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Typing of Clinical Herpes Simplex Virus Type 1 and Type 2 Isolates with Monoclonal Antibodies

Journal of Clinical Microbiology ◽

10.1128/jcm.37.8.2717-2718.1999 ◽

1999 ◽

Vol 37 (8) ◽

pp. 2717-2718 ◽

Cited By ~ 13

Author(s):

Jan-Åke Liljeqvist ◽

Bo Svennerholm ◽

Tomas Bergström

Keyword(s):

Monoclonal Antibody ◽

Monoclonal Antibodies ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Glycoprotein C ◽

Glycoprotein G ◽

Simplex Virus ◽

Hsv 1

The purpose of this study was to evaluate the performance of a herpes simplex virus (HSV) type 1-specific anti-glycoprotein C-1 monoclonal antibody (MAb) and a type 2-specific anti-glycoprotein G-2 MAb for typing of 2,400 clinical HSV-1 isolates and 2,400 clinical HSV-2 isolates, respectively, using an enzyme immunoassay. The anti-HSV-1 MAb showed sensitivity and specificity of 100%, and the anti-HSV-2 MAb showed a sensitivity of 99.46% and 100% specificity, indicating that these MAbs are suitable for typing of clinical HSV isolates.

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