Noradrenaline Content and Release in the Mesenteric Artery of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) and a New Strain of SHRSP (M-SHRSP)

1987 ◽  
Vol 24 (6) ◽  
pp. 334-338 ◽  
Author(s):  
Keiichi Shimamura ◽  
Tomoko Shimada ◽  
Kazuo Yamamoto ◽  
Satoru Sunano ◽  
Kozo Okamoto
Keyword(s):  
Mesenteric Artery ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Noradrenaline Content ◽  
Spontaneously Hypertensive

Early Changes in Noradrenaline Content of Some Brain Nuclei in Spontaneously Hypertensive Rats

1980 ◽  
Vol 59 (s6) ◽  
pp. 243s-245s ◽  
Author(s):  
Kim Hanh Le Quan-Bui ◽  
Jean-Luc Elghozi ◽  
Marie-Aude Devynck ◽  
Philippe Meyer
Keyword(s):  
High Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Cardiovascular Regulation ◽  
Hypertensive Rats ◽  
Salt Treatment ◽  
Noradrenaline Content ◽  
Brain Nuclei ◽  
Spontaneously Hypertensive ◽  
Hypothalamic Nuclei ◽  
Adrenergic Activity

1. The noradrenaline content of individual brain nuclei was measured by using high-pressure liquid chromatography coupled with electrochemical detection. 2. This study was performed on spontaneously hypertensive rats during the development of hypertension (4 and 12 weeks) and also on deoxycorticosterone-salt hypertensive rats after 1 and 4 weeks of treatment. 3. In young spontaneously hypertensive rats a significant decrease in noradrenaline content was observed in some medullary and hypothalamic nuclei which are involved in cardiovascular regulation. No change was observed after deoxycorticosterone-salt treatment. 4. It is proposed that a change in adrenergic activity, restricted to brain cardiovascular centres, could represent a mechanism triggering spontaneous hypertension.

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