Three-Dimensional Geometries Representing the Retinal Nerve Fiber Layer in Multiple Sclerosis, Optic Neuritis, and Healthy Eyes

2013 ◽  
Vol 50 (1) ◽  
pp. 72-81 ◽  
Author(s):  
Elena Garcia-Martin ◽  
Begoña Calvo ◽  
Mauro Malvè ◽  
Raquel Herrero ◽  
Isabel Fuertes ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Three Dimensional ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Healthy Eyes ◽  
Retinal Nerve Fiber

Axonal loss in the retinal nerve fiber layer in patients with multiple sclerosis

2008 ◽  
Vol 14 (5) ◽  
pp. 609-614 ◽  
Author(s):  
V Pueyo ◽  
J Martin ◽  
J Fernandez ◽  
C Almarcegui ◽  
J Ara ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Axonal Loss ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Healthy Eyes ◽  
Retinal Nerve Fiber

Objective To quantify axonal loss in the retinal nerve fiber layer (RNFL) in patients with multiple sclerosis (MS), with and without a history of optic neuritis, by means of ocular imaging technologies. Methods This cross-sectional study enrolled 50 patients with MS and 25 age- and sex-matched healthy controls. All patients underwent neurologic assessment and a complete ophthalmic examination that included visual acuity, visual field examination, optical coherence tomography (OCT), scanning laser polarimetry (GDx) and visual evoked potentials (VEPs). Visual parameters and RNFL measurements were evaluated in MS eyes with a prior optic neuritis episode (MS-ON), with no prior episode (MS-NON) and control subjects. Results There were significant differences ( p < 0.05, analysis of variance) between MS-ON ( n = 25 eyes) and healthy eyes ( n = 25 eyes) for all RNFL parameters measured by OCT and GDx. Significant differences between MS-NON ( n = 75 eyes) and healthy eyes were also found for most of these parameters. RNFL thickness in the temporal quadrant was the parameter with the greatest differences between groups (71.79 μm in healthy eyes, 60.29 μm in MS-NON and 53.92 μm in MS-ON, p < 0.0005). Although there was a highly significant but moderate correlation between RNFL thickness and duration of the disease, no correlation was observed between RNFL thickness and neurologic impairment (Expanded Disability Status Scale). Conclusions Axonal loss was detected not only in MS eyes with a previous acute optic neuritis, but also in MS eyes with no known optic neuritis episode. Structural abnormalities correlate with functional assessments of the optic nerve.

Cholesterol affects retinal nerve fiber layer thickness in patients with multiple sclerosis with optic neuritis

2013 ◽  
Vol 20 (9) ◽  
pp. 1264-1271 ◽  
Author(s):  
A. Kardys ◽  
B. Weinstock-Guttman ◽  
M. Dillon ◽  
M. W. Masud ◽  
N. Weinstock ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Retinal Nerve Fiber

Retinal nerve fiber layer thickness changes following optic neuritis caused by multiple sclerosis

2011 ◽  
Vol 55 (1) ◽  
pp. 45-48 ◽  
Author(s):  
Toru Urano ◽  
Toyoaki Matsuura ◽  
Eiichi Yukawa ◽  
Mikki Arai ◽  
Yoshiaki Hara ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Retinal Nerve Fiber

Progressive Changes in the Retinal Nerve Fiber Layer in Patients with Multiple Sclerosis

2010 ◽  
Vol 20 (1) ◽  
pp. 167-173 ◽  
Author(s):  
Elena García-Martín ◽  
Victoria Pueyo ◽  
Jesus Martin ◽  
Carmen Almarcegui ◽  
Jose R. Ara ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber
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