Axonal loss in the retinal nerve fiber layer in patients with multiple sclerosis

2008 ◽  
Vol 14 (5) ◽  
pp. 609-614 ◽  
Author(s):  
V Pueyo ◽  
J Martin ◽  
J Fernandez ◽  
C Almarcegui ◽  
J Ara ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Axonal Loss ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Healthy Eyes ◽  
Retinal Nerve Fiber

Objective To quantify axonal loss in the retinal nerve fiber layer (RNFL) in patients with multiple sclerosis (MS), with and without a history of optic neuritis, by means of ocular imaging technologies. Methods This cross-sectional study enrolled 50 patients with MS and 25 age- and sex-matched healthy controls. All patients underwent neurologic assessment and a complete ophthalmic examination that included visual acuity, visual field examination, optical coherence tomography (OCT), scanning laser polarimetry (GDx) and visual evoked potentials (VEPs). Visual parameters and RNFL measurements were evaluated in MS eyes with a prior optic neuritis episode (MS-ON), with no prior episode (MS-NON) and control subjects. Results There were significant differences ( p < 0.05, analysis of variance) between MS-ON ( n = 25 eyes) and healthy eyes ( n = 25 eyes) for all RNFL parameters measured by OCT and GDx. Significant differences between MS-NON ( n = 75 eyes) and healthy eyes were also found for most of these parameters. RNFL thickness in the temporal quadrant was the parameter with the greatest differences between groups (71.79 μm in healthy eyes, 60.29 μm in MS-NON and 53.92 μm in MS-ON, p < 0.0005). Although there was a highly significant but moderate correlation between RNFL thickness and duration of the disease, no correlation was observed between RNFL thickness and neurologic impairment (Expanded Disability Status Scale). Conclusions Axonal loss was detected not only in MS eyes with a previous acute optic neuritis, but also in MS eyes with no known optic neuritis episode. Structural abnormalities correlate with functional assessments of the optic nerve.

Three-Dimensional Geometries Representing the Retinal Nerve Fiber Layer in Multiple Sclerosis, Optic Neuritis, and Healthy Eyes

2013 ◽  
Vol 50 (1) ◽  
pp. 72-81 ◽  
Author(s):  
Elena Garcia-Martin ◽  
Begoña Calvo ◽  
Mauro Malvè ◽  
Raquel Herrero ◽  
Isabel Fuertes ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Three Dimensional ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Healthy Eyes ◽  
Retinal Nerve Fiber

scholarly journals Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis

2008 ◽  
Vol 14 (7) ◽  
pp. 906-912 ◽  
Author(s):  
J Toledo ◽  
J Sepulcre ◽  
A Salinas-Alaman ◽  
A García-Layana ◽  
M Murie-Fernandez ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Thickness Measurement ◽  
Cognitive Disability ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Tissue Changes ◽  
Retinal Nerve Fiber

Background Studying axonal loss in the retina is a promising biomarker for multiple sclerosis (MS). Our aim was to compare optical coherence tomography (OCT) and Heidelberg retinal tomography (HRT) techniques to measure the thickness of the retinal nerve fiber layer (RNFL) in patients with MS, and to explore the relationship between changes in the RNFL thickness with physical and cognitive disability. We studied 52 patients with MS and 18 proportionally matched controls by performing neurological examination, neuropsychological evaluation using the Brief Repetitive Battery-Neuropsychology and RNFL thickness measurement using OCT and HRT. Results We found that both OCT and HRT could define a reduction in the thickness of the RNFL in patients with MS compared with controls, although both measurements were weakly correlated, suggesting that they might measure different aspects of the tissue changes in MS. The degree of RNFL atrophy was correlated with cognitive disability, mainly with the symbol digit modality test ( r = 0.754, P < 0.001). Moreover, temporal quadrant RNFL atrophy measured with OCT was associated with physical disability. Conclusion In summary, both OCT and HRT are able to detect thinning of the RNFL, but OCT seems to be the most sensitive technique to identify changes associated with MS evolution.

scholarly journals Retinal Nerve Fiber Layer and Future Risk of Multiple Sclerosis

2008 ◽  
Vol 35 (4) ◽  
pp. 482-487 ◽  
Author(s):  
Fiona Costello ◽  
William Hodge ◽  
Y. Irene Pan ◽  
Luanne Metz ◽  
Randy H. Kardon
Keyword(s):  
Multiple Sclerosis ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Increased Risk ◽  
Conversion Time ◽  
One Year ◽  
Retinal Nerve Fiber

Background:Optical coherence tomography (OCT) - measured retinal nerve fiber layer (RNFL) values may represent a surrogate biomarker for axonal integrity in multiple sclerosis (MS). The purpose of this study was to determine whether RNFL measurements obtained within two years of an optic neuritis (ON) event distinguish patients at increased risk of developing clinically-definite MS (CDMS).Methods:Fifty consecutively sampled patients who experienced a single ON event were followed prospectively for a mean period of 34 months with OCT testing. Values of RNFL in clinically-affected and non-affected eyes were compared between patients who developed CDMS and those that did not develop MS after ON.Findings:Twenty-one patients (42%) developed CDMS during the course of the study, with a mean conversion time of 27 months. Mean RNFL values were thinner in the clinically - affected eyes of non - MS patients than CDMS eyes after one year (p = 0.0462) due to more severe ON events in the former. By year two, CDMS patients manifested more recurrent ON events and RNFL thinning than non - MS patients. Temporal RNFL values were thinner in the non-affected eyes of CDMS patients with a trend towards significance (p = 0.1302).Interpretation:Our results indicate that RNFL thickness does not reliably distinguish patients at higher risk of converting to CDMS after ON. The severity of ON has a greater effect on RNFL thickness than risk of CDMS at one year. The CDMS patients demonstrate progressive RNFL thinning likely due to recurrent sub-clinical ON events, which may help differentiate them from non - MS patients over time.

scholarly journals Oral lipoic acid as a treatment for acute optic neuritis: a blinded, placebo controlled randomized trial

2019 ◽  
Vol 5 (2) ◽  
pp. 205521731985019 ◽  
Author(s):  
Julie Falardeau ◽  
Allison Fryman ◽  
Rohan Wanchu ◽  
Gail H Marracci ◽  
Michele Mass ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Lipoic Acid ◽  
Fiber Layer ◽  
Double Blind ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Acute Optic Neuritis ◽  
Retinal Nerve Fiber

Background Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis. Optical coherence tomography can detect retinal nerve fiber layer thinning, representing axonal degeneration, approximately 3–6 months after acute optic neuritis. Objective To determine whether lipoic acid is neuroprotective in acute optic neuritis. Methods A single-center, double-blind, randomized, placebo controlled, 24-week trial. Intervention included 6 weeks of once daily lipoic acid (1200 mg) or placebo within 14 days of acute optic neuritis diagnosis. The primary outcome was the mean difference in affected eye retinal nerve fiber layer (RNFL) thickness from baseline to 24 weeks. Results We enrolled 31 subjects (placebo n=16; lipoic acid n=15; average age 38.6 years (standard deviation (SD) 10.3)). Affected eye mean global RNFL thickness (µm) in the lipoic acid group decreased from 108.47 (SD 26.11) at baseline to 79.31 (SD 19.26) at 24 weeks. The affected eye RNFL in the placebo group decreased from 103.67 (SD 18.04) at baseline to 84.43 (SD 20.94) at 24 weeks. Unaffected eye RNFL thickness did not significantly change in either group over 24 weeks. Conclusion Six weeks of oral lipoic acid supplementation after acute optic neuritis is safe and well tolerated; however, because of insufficient recruitment, we could not conclude that lipoic acid treatment was neuroprotective in acute optic neuritis.

Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis

2005 ◽  
Vol 58 (3) ◽  
pp. 383-391 ◽  
Author(s):  
S. Anand Trip ◽  
Patricio G. Schlottmann ◽  
Stephen J. Jones ◽  
Daniel R. Altmann ◽  
David F. Garway-Heath ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Axonal Loss ◽  
Fiber Layer ◽  
Visual Dysfunction ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber

scholarly journals Retinal Nerve Fiber Layer Thickness in Multiple Sclerosis With and Without Optic Neuritis: a Four-year Follow-up Study

2021 ◽  
Author(s):  
Abdullah S. Al-Mujaini ◽  
Maiysa S. Al-Mujaini ◽  
Buthaina I. Sabt
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Control Group ◽  
Healthy Controls ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness

Abstract Background: Multiple sclerosis (MS) is an autoimmune disease that attacks the central nervous system, with optic neuritis (ON) being a common early manifestation. Retinal nerve fiber layer (RNFL) thickness may be a biomarker of neuroaxonal damage in MS patients. We sought to evaluate changes in RNFL thickness over four years in Omani MS patients with or without ON in comparison to a healthy control group. Methods: This retrospective case-control study involved 27 MS patients and 25 healthy controls. Optical coherence tomography was performed upon first diagnosis and at a four-year follow-up. Differences in mean RNFL thickness were calculated. Results: A total of 51 eyes from the MS group and 50 eyes from the control group were evaluated. There was a significant reduction in mean RNFL thickness among MS patients with ON at follow-up (81.21 versus 72.14 µm; P = .003), whereas no significant RNFL thinning was observed among MS patients without ON. However, there was a significant reduction in RNFL thickness among MS patients compared to healthy controls (76.79 versus 93.72 µm; P = .009), regardless of ON presence/absence. Conclusions: Axonal damage was seen in the optic nerves of Omani MS patients. Moreover, there was a significant reduction in RNFL thickness among MS patients with ON as the disease progressed; however, while there was evidence of RNFL thinning in MS patients without ON, this difference lacked statistical significance. Evaluation of RNFL thickness may represent a useful biomarker for monitoring disease progression in MS and its association with ON.

Cholesterol affects retinal nerve fiber layer thickness in patients with multiple sclerosis with optic neuritis

2013 ◽  
Vol 20 (9) ◽  
pp. 1264-1271 ◽  
Author(s):  
A. Kardys ◽  
B. Weinstock-Guttman ◽  
M. Dillon ◽  
M. W. Masud ◽  
N. Weinstock ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Retinal Nerve Fiber
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