Tiaprofenic Acid: A Brief Review of Its Analgesic and Anti-Inflammatory Action and a Double-Blind, Controlled Study in Osteoarthritis of the Knee Compared with Diclofenac Sodium

2015 ◽  
pp. 14-19
Author(s):  
F. Sampirisi-Aprile
Keyword(s):  
Diclofenac Sodium ◽  
Tiaprofenic Acid ◽  
Controlled Study ◽  
Osteoarthritis Of The Knee ◽  
Double Blind ◽  
Anti Inflammatory ◽  
Inflammatory Action

A Comparative Double-Blind Study of Tiaprofenic Acid and Aspirin in the Treatment of Muscular Rheumatism, Fibrositis, Sprains and Soft Tissue Injuries in General Practice

1980 ◽  
Vol 8 (6) ◽  
pp. 382-387 ◽  
Author(s):  
J F Donald ◽  
A Layes Molla
Keyword(s):  
General Practice ◽  
Soft Tissue ◽  
Tiaprofenic Acid ◽  
Soft Tissue Injuries ◽  
Double Blind Study ◽  
Double Blind ◽  
Anti Inflammatory ◽  
Tissue Injuries ◽  
Inflammatory Action ◽  
Better Than

Analgesic and anti-inflammatory properties of tiaprofenic acid 200 mg t.d.s. were compared with those of aspirin 600 mg t.d.s. in 100 patients in general practice suffering from muscular rheumatic pain, fibrositis, sprains and soft tissue injuries. Tiaprofenic acid was shown to be better than aspirin in relieving pain by clinical assessment although both drugs were equally effective according to patients daily assessment. It was not possible to demonstrate any anti-inflammatory action by reduction of swelling, but this was only present in 20% of patients initially. Side-effects, none serious, were similar in both groups.

Effect of Some Anti-Inflammatory Drugs on Human Neutrophil Chemotaxis

1994 ◽  
Vol 22 (2) ◽  
pp. 100-106 ◽  
Author(s):  
G Hasçelik ◽  
B ŞLener ◽  
Z Hasçelik
Keyword(s):  
Acetylsalicylic Acid ◽  
Polymorphonuclear Leukocyte ◽  
Polymorphonuclear Leukocytes ◽  
Diclofenac Sodium ◽  
Tiaprofenic Acid ◽  
Boyden Chamber ◽  
Random Migration ◽  
Leukocyte Chemotaxis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The effects of piroxicam, tenoxicam, diclofenac sodium, acetylsalicylic acid and tiaprofenic acid on the chemotaxis and random migration of human polymorphonuclear leukocytes were investigated, using zymosan-activated serum as chemo-attractant, with a modified Boyden chamber technique. All five compounds significantly reduced chemotaxis. The random migration of polymorphonuclear leukocytes was inhibited by piroxicam, diclofenac sodium and tiaprofenic acid but not by tenoxicam or acetylsalicylic acid. The inhibitory effect of these non-steroidal anti-inflammatory drugs on polymorphonuclear leukocyte chemotaxis and on random migration was generally dose-dependent. The results suggest that the drugs studied may have a direct effect on polymorphonuclear leukocyte chemotaxis and that this activity may contribute to their anti-inflammatory properties.

RETRACTED: A Randomized, Double-Blind, Placebo-Controlled Study Assessing the Anti-inflammatory Effects of Ketamine in Cardiac Surgical Patients

2006 ◽  
Vol 20 (2) ◽  
pp. 217-222 ◽  
Author(s):  
Cristian Bartoc ◽  
Robert J. Frumento ◽  
Maya Jalbout ◽  
Elliott Bennett-Guerrero ◽  
Evelyn Du ◽  
...  
Keyword(s):  
Surgical Patients ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Anti Inflammatory
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