Levels of CD4+ Lymphocytes, Neopterin, and �2-Microglobulin Are Early Predictors of Acquired Immunodeficiency Syndrome

2015 ◽  
pp. 61-73 ◽  
Author(s):  
Alexander Kr�mer ◽  
Robert J. Biggar ◽  
Dietmar Fuchs ◽  
Philip S. Rosenberg ◽  
Mitchell H. Gail ◽  
...  
Keyword(s):  
Acquired Immunodeficiency Syndrome ◽  
Early Predictors ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Cd4 Lymphocytes

scholarly journals Immunological abnormalities of acquired immunodeficiency syndrome and related disorders in patients from Rio de Janeiro, Brazil

1988 ◽  
Vol 83 (3) ◽  
pp. 305-311 ◽  
Author(s):  
W. Miranda-Silva ◽  
B. Galvão-Castro ◽  
M. G. Bonecini-Almeida ◽  
C. T. Daniel-Ribeiro ◽  
F. S. Sion ◽  
...  
Keyword(s):  
Acquired Immunodeficiency Syndrome ◽  
Relative Increase ◽  
T Helper ◽  
Cd8 Cells ◽  
The World ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Immunological Abnormalities ◽  
Cd4 Lymphocytes ◽  
Immunological Alterations

The immunoloical profile of acquired immunodeficiency syndrome (AIDS) and chronic lymphadenopathy syndrome (CLAS) in 15 and 11 Brazilian patients, respectively, was studied. The AIDS patients showed reduced percentage of total T (CD3) and T-helper-inducer (CD4) lymphocytes, relative increase in numbers of T-suppressor-cytotoxic (CD8) cells and a marked inversion of T-helper-inducer/suppressor-cytotoxic (CD4/CD8) ratio. Lymphoproliferative responses to PHA, ConA, PPD and PWM were diminished. Hypergamaglobulinemia and high levels of circulating immune complexes were also found. The CLAS patients also showed important immunological alterations, but not so intense as those with AIDS. These data seems to be similar to those observed in other parts of the world.

Sign in / Sign up

Export Citation Format

Share Document