Severe Adverse Reaction to Vemurafenib in a Pregnant Woman with Metastatic Melanoma

Targeted therapies have drastically changed the management of metastatic melanoma and have shown encouraging results on tumour progression but are also known for their high rates of adverse reactions. In general, targeted therapies are contraindicated during pregnancy due to concerns about teratogenesis. For the BRAF V600 inhibitor vemurafenib, the available literature about the effects on human pregnancy is limited to a single case report. In patients with metastatic melanoma that wish to continue their pregnancy, targeted therapies like vemurafenib offer the only possibility of improving maternal outcome. In this article, we report on a pregnant woman with metastatic melanoma who was treated with vemurafenib during pregnancy and experienced a fatal adverse reaction.

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Late Brachial Plexopathy due to Radiation-Induced Fibrosis. A single case report illustrating the importance of electrophysiology and MRI in differenzial diagnostics for delayed radiation-induced plexopathy

Klinische Neurophysiologie ◽

10.1055/s-0030-1250843 ◽

2010 ◽

Vol 41 (01) ◽

Author(s):

TN Witt ◽

UM Ganswindt ◽

A Staebler ◽

C Weiss

Keyword(s):

Case Report ◽

Single Case ◽

Brachial Plexopathy ◽

Single Case Report ◽

Radiation Induced

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A rare coexistence of acromegaly, myasthenia gravis, sicca syndrome, and elevated serum IgG4 levels: A single case report

Endocrine Abstracts ◽

10.1530/endoabs.70.aep708 ◽

2020 ◽

Author(s):

Wan-Chen Wu ◽

Huang Abel Po-Hao

Keyword(s):

Case Report ◽

Myasthenia Gravis ◽

Single Case ◽

Elevated Serum ◽

Sicca Syndrome ◽

Single Case Report ◽

Serum Igg4

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Sequential bilateral Behçet’s neuroretinitis associated with prepapillary vitreous exudate: case report

Journal of Ophthalmic Inflammation and Infection ◽

10.1186/s12348-020-00226-y ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Imen Ksiaa ◽

Safa Ben Aoun ◽

Sourour Zina ◽

Dhouha Nefzi ◽

Sana Khochtali ◽

...

Keyword(s):

Case Report ◽

Single Case ◽

Signal Loss ◽

Fiber Layer ◽

Swept Source ◽

Single Case Report ◽

Shadowing Effect ◽

Eye Involvement ◽

The Right ◽

Inflammatory Changes

Abstract Objective To describe a case of Behçet disease (BD) uveitis manifesting with sequential bilateral neuroretinitis associated with prepapillary inflammatory vitreous exudate (PIVE). Material and methods A single case report documented with multimodal imaging. Results A 37-year-old man developed neuroretinitis with associated PIVE in the left eye. He was diagnosed with ocular toxoplasmosis and treated accordingly based on positive serologic testing and negative work-up for other entities, including BD. The disease course was favorable, but 1 year later a similar neuroretinitis developed in the right eye. Extraocular features of BD became evident only at the time of the second eye involvement, and the patient received corticosteroid and immunosuppressive therapy. Swept source (SS) OCT showed at the acute phase in both eyes a typical “mushroom-shaped” prepapillary hyperreflectivity of the PIVE. SS OCT angiography (OCTA) demonstrated a corresponding prepapillary hypointense area due to shadowing effect, decreasing in size while scanning deeper layers. It also detected peripapillary retinal hypervascularity in both eyes and a sectoral area of flow signal loss in the first involved left eye. Visual acuity improved following the resolution of the PIVE and associated acute inflammatory changes in both eyes. The left eye showed residual optic disc pallor and retinal nerve fiber layer defects. Conclusion Sequential bilateral neuroretinitis associated with PIVE may occur before other clinical features of BD become evident. SS OCT and OCTA can provide useful information for the diagnosis and management of this rare, but typical, ocular manifestation of BD uveitis.

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