Abstract 20155: The Adverse Effect of End Stage Renal Disease on Intimal Hyperplasia of Internal Thoracic Artery

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Hirofumi Sato ◽  
Yuko Ohashi ◽  
Chikara Ueki ◽  
Takehide Akimoto ◽  
Genichi Sakaguchi
Keyword(s):  
Renal Disease ◽  
Intimal Hyperplasia ◽  
End Stage Renal Disease ◽  
Artery Bypass ◽  
Rank Correlation ◽  
Arterial Disease ◽  
Off Pump ◽  
Luminal Narrowing ◽  
Stage Renal Disease ◽  
End Stage

Introduction: Internal thoracic arteries (ITA) are widely used as a reliable conduit in coronary artery bypass grafting surgery (CABG) because they are said to be less affected by arterioscrelosis. Little is known about the relationships between patient’s characteristics and intimal hyperplasia of ITAs. Hypothesis: The condition of intima of ITA of patients with end stage renal disease (ESRD) is worse than those of patients without ESRD. Methods: The specimens of LITAs and RITAs, obtained from 48 patients who underwent CABG or OPCAB (off-pump CABG) , were evaluated with histopathology; 56 arteries were suitable for morphometric analysis. The severity of disease was evaluated on the basis of percentage of luminal narrowing (%LN) , intimal thickness index (ITI), and intima-to-media ratio (IMR). Results: The patients included 36 males, 15 ESRD, 11 HD patients, 8 peripheral arterial disease (PAD) patients, and their average age was 69.3, average estimated glomerular filtration rate (eGFR) was 49.0 ml/min/1.73m 2 . The %LN was 6.26, ITI was 0.24, and IMR was 0.96 in average. In Spearman's rank correlation test, eGFR was associated with %LN (correlation coefficient -0.242, p=0.07). The %LN of patients with ESRD was significantly higher than that of patients without ESRD ( 7.99 vs 5.48, p=0.001). Conclusions: The lumen of ITAs of patients with ESRD was significantly narrower than that of patients without ESRD.

Off-Pump Coronary Artery Bypass Grafting in Patients with End-Stage Renal Disease on Hemodialysis

2010 ◽  
Vol 17 (5) ◽  
pp. 377-382 ◽  
Author(s):  
Tadashi Tashiro ◽  
Katsuhiko Nakamura ◽  
Noritsugu Morishige ◽  
Akio Iwakuma ◽  
Yutaka Tachikawa ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Artery Bypass ◽  
Bypass Grafting ◽  
Off Pump ◽  
Pump Coronary Artery Bypass ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Peripheral Arterial Disease Screening in End-Stage Renal Disease

2013 ◽  
Vol 57 (5) ◽  
pp. 54S
Author(s):  
Houssam K. Younes ◽  
Mark G. Davies ◽  
Javier Anaya-ayala ◽  
Hosam F. El-Sayed ◽  
Jean Bismuth ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Arterial Disease ◽  
Disease Screening ◽  
Peripheral Arterial ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals 504. Epidemiology of End-stage Renal Disease (ESRD) Patients with Carbapenem-Resistant Enterobacteriaceae (CRE) Infections: Atlanta Metropolitan Area, 2012–2017

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S244-S245
Author(s):  
Jacqueline M Hurd ◽  
Chris W Bower ◽  
Jesse T Jacob
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Population Data ◽  
Arterial Disease ◽  
Population Based ◽  
Emerging Infections ◽  
Carbapenem Resistant ◽  
Stage Renal Disease ◽  
End Stage ◽  
Carbapenem Resistant Enterobacteriaceae

Abstract Background Patients with end-stage renal disease (ESRD) have higher risks for resistant organisms including carbapenem-resistant Enterobacteriaceae (CRE). To explore the effect of ESRD on CRE, we compared characteristics of CRE cases with and without ESRD in a population-based cohort. Methods The Georgia Emerging Infections Program has performed active laboratory- and population-based surveillance for CRE in metropolitan Atlanta (4.1 million in 2017) since 2012. CRE cases are defined by isolation from a sterile body site or urine of E. coli, K. pneumoniae, K. oxytoca, K. aerogenes, or E. cloacae. From 2012 to 2015, cultures were resistant to all third-generation cephalosporins tested and non-susceptible to ≥1 carbapenem (excluding ertapenem). After 2016, cultures were resistant to ≥1 carbapenems. Epidemiologic data including ESRD were collected via medical chart review. ESRD population data were obtained from the US Renal Data System. Georgia vital records data were used to determine 90-day mortality rates. Prevalence estimates were calculated. Comparisons used a χ 2 test. Results Of 1,511 CRE cases, 136 (9%) were on current chronic dialysis, 128 (94%) of which were on hemodialysis (HD) and 5 (4%) were on peritoneal dialysis. Among CRE cases with HD, 94 (73%) had a catheter and 30 (23%) had an arteriovenous fistula or graft. CRE cases with ESRD were more likely to be male (58% vs. 40%), black (76% vs. 38%), and have diabetes (67% vs. 38%), congestive heart failure (25% vs. 17%), or peripheral arterial disease (12% vs. 4%). CRE cases with ESRD had more hospitalizations within 30 days of the culture date (77% vs. 47%), ICU admissions prior to (29% vs. 7%) or after the culture date (43% vs. 14%) and discharges to LTCFs (35% vs. 15%) after hospitalization. CRE cases with ESRD and bacteremia were more likely to have been hospitalized >3 days before the culture compared with CRE cases with ESRD and positive cultures from other body sites (52% vs. 24%). The 90-day mortality rate per 100,000 population was higher among CRE cases with ESRD (100.9 cases) than without ESRD (1.0 cases). Conclusion Among a population-based cohort of patients with CRE infections, ESRD comprised ~10% but had markedly mortality, suggesting that future interventions should target ESRD. Disclosures All authors: No reported disclosures.

Potential Nontraditional Applications of Statins

2003 ◽  
Vol 37 (7-8) ◽  
pp. 1063-1071 ◽  
Author(s):  
James M McKenney
Keyword(s):  
Peripheral Arterial Disease ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Acute Coronary Syndromes ◽  
Arterial Disease ◽  
Data Sources ◽  
Coronary Syndromes ◽  
Peripheral Arterial ◽  
Stage Renal Disease ◽  
End Stage

OBJECTIVE: To review the current evidence for use of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) in nontraditional lipid-related applications, including acute coronary syndromes, peripheral arterial disease, stroke, and renal disease, and to describe ongoing trials evaluating the role of statins in these conditions. DATA SOURCES: Clinical literature was identified by a MEDLINE search (1990–November 2002) using ≥1 of the following search terms: acute coronary syndrome(s), angina pectoris, atherosclerosis, atorvastatin, clinical trials, diabetes mellitus, end-stage renal disease, fluvastatin, lovastatin, myocardial infarction, peripheral arterial disease, pravastatin, simvastatin, statins, and stroke. Treatment guidelines issued by professional and governmental organizations, such as the American Diabetes Association, American Heart Association, National Cholesterol Education Program, National Kidney Foundation, and National Stroke Foundation, were reviewed. STUDY SELECTION AND DATA EXTRACTION: Articles identified from the data sources were included if they pertained to the conditions described in the objectives and provided unique information concerning use of statins. DATA SYNTHESIS: Substantial evidence exists for the use of statins in acute coronary syndromes. Meta-analyses of data from major clinical trials indicate that statins prevent first and recurrent stroke, and large-scale trials are underway to evaluate the efficacy of statins in this setting. Accumulating evidence suggests that statins may be beneficial in reducing the morbidity and mortality associated with peripheral arterial disease and end-stage renal disease, and results from ongoing trials may confirm these benefits. Statins may also have a future role in amelioration of other conditions associated with atherosclerosis, such as diabetes mellitus. CONCLUSIONS: A large body of evidence supports the evaluation of statins in clinical settings beyond primary and secondary prevention of morbidity and mortality associated with coronary atherosclerosis.

Memory performance in adequately dialyzed patients with end-stage renal disease: Is there an association with coronary artery bypass grafting?

2010 ◽  
Vol 32 (8) ◽  
pp. 881-889 ◽  
Author(s):  
Michal Harciarek ◽  
John B. Williamson ◽  
Bogdan Biedunkiewicz ◽  
Monika Lichodziejewska-Niemierko ◽  
Alicja Dębska-Ślizień ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Renal Disease ◽  
Coronary Artery Bypass ◽  
End Stage Renal Disease ◽  
Memory Performance ◽  
Artery Bypass ◽  
Bypass Grafting ◽  
Stage Renal Disease ◽  
End Stage
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