Many human-shaped landscapes support viable amphibian populations due to the habitats created and/or maintained as a consequence of human actions. The challenges and approaches required to achieve the persistence of amphibians in human-shaped landscapes are markedly different from approaches commonly applied in protected areas. Contrary to protected areas or natural landscapes where amphibian conservationists can have direct control over management, in human-shaped landscapes, management options are best approached through understanding local communities’ values and socio-economic aspirations. However, consideration of the social aspects of amphibian conservation are vastly under-represented in the amphibian conservation literature. We propose that amphibian conservationists should: (i) assess the controllability of their mitigation actions for achieving long-term sustainability, (ii) understand the values and attitudes of individual landowners towards amphibians and amphibian-friendly management (local scale) and land stewardship on which amphibian conservation initiatives can be built (landscape scale), and (iii) understand the social and economic drivers of land-use change operating at regional levels, which is crucial for building adaptive potential in conservation programs. Since targeted amphibian conservation initiatives are limited in many human-shaped landscapes, consideration of the socio-economic context conducive to amphibian persistence is crucial.