scholarly journals EVEREST Report 5: Clinical Outcomes and Treatment Response of Polypoidal Choroidal Vasculopathy Subtypes in a Multicenter, Randomized Controlled Trial

2018 ◽  
Vol 59 (2) ◽  
pp. 889 ◽  
Author(s):  
Colin S. Tan ◽  
Louis W. Lim ◽  
Wei Kiong Ngo ◽  
Tock Han Lim ◽  
Keyword(s):  
Randomized Controlled Trial ◽  
Treatment Response ◽  
Clinical Outcomes ◽  
Polypoidal Choroidal Vasculopathy ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Multicenter Randomized Controlled Trial ◽  
Choroidal Vasculopathy

Long-term clinical outcomes of valsartan in patients with a systemic right ventricle: Follow-up of a multicenter randomized controlled trial

2019 ◽  
Vol 278 ◽  
pp. 84-87 ◽  
Author(s):  
Alexandra C. van Dissel ◽  
Michiel M. Winter ◽  
Teun van der Bom ◽  
Hubert W. Vliegen ◽  
Arie P.J. van Dijk ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Right Ventricle ◽  
Clinical Outcomes ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Systemic Right Ventricle ◽  
Multicenter Randomized Controlled Trial

scholarly journals Arthroscopic microfracture with atelocollagen augmentation for osteochondral lesion of the talus: a multicenter randomized controlled trial

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Young Koo Lee ◽  
Ki Won Young ◽  
Jin Su Kim ◽  
Hong Seop Lee ◽  
Whi-Je Cho ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Clinical Outcomes ◽  
Controlled Trial ◽  
Osteochondral Lesion ◽  
Randomized Controlled ◽  
Arthroscopic Microfracture ◽  
Multicenter Randomized Controlled Trial ◽  
Group 2 ◽  
Group 1

Abstract Background We aimed to evaluate whether arthroscopic microfracture with atelocollagen augmentation could improve the clinical outcomes and quality of regenerated cartilage in patients with osteochondral lesion of the talus (OLT). We hypothesized that the clinical outcomes and quality of the regenerated cartilage would be superior in patients undergoing arthroscopic microfracture with atelocollagen augmentation compared to those undergoing arthroscopic microfracture alone. Methods In this multicenter, randomized controlled trial, 60 patients were randomly allocated to two groups: arthroscopic microfracture with atelocollagen augmentation (group 1, n = 31) and arthroscopic microfracture alone (group 2, n = 29). Mean 100-mm visual analog scale (VAS), Hannover scoring system (HSS), and American Orthopedic Foot and Ankle Society (AOFAS) scores were assessed 2 years postoperatively and compared between the groups. The quality of the regenerated cartilage was assessed according to the Magnetic Resonance Observation of CArtilage Repair Tissue (MOCART) score based on magnetic resonance imaging. Results Forty-six patients (22 in group 1, 23 in group 2) completed the 2-year follow-up. The quality of the regenerated cartilage assessed based on the MOCART score was significantly superior in group 1 compared to group 2 (64.49 ± 18.27 vs 53.01 ± 12.14, p = 0.018). Clinical outcomes in terms of 100-mm VAS (17.25 ± 20.31 vs 19.37 ± 18.58, p = 0.72), HSS (93.09 ± 13.64 vs 86.09 ± 13.36, p = 0.14), and AOFAS (91.23 ± 8.62 vs 86.91 ± 10.68, p = 0.09) scores were superior in group 1 compared to group 2, but the differences were not statistically significant. Both groups showed significant improvements in clinical outcomes compared with the preoperative values. Conclusion The quality of the regenerated cartilage was superior after arthroscopic microfracture with atelocollagen augmentation compared to that after microfracture alone in patients with OLT. Clinical outcomes assessed 2 years postoperatively were superior in patients who underwent arthroscopic microfracture with atelocollagen augmentation compared to those who underwent arthroscopic microfracture alone, although the differences were not statistically significant. A long-term study of the cohort is required to confirm these findings. Trial registration ClinicalTrials.gov (NCT02519881), August 11, 2015.

Simplified edentulous treatment: A multicenter randomized controlled trial to evaluate the timing and clinical outcomes of the technique

2017 ◽  
Vol 118 (4) ◽  
pp. 462-467 ◽  
Author(s):  
Paola Ceruti ◽  
Nicola Mobilio ◽  
Elisabetta Bellia ◽  
Andrea Borracchini ◽  
Santo Catapano ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Clinical Outcomes ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Multicenter Randomized Controlled Trial
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