scholarly journals Guinea pigs with inherited deficiencies of complement components C2 or C4 have characteristics of immune complex disease.

1986 ◽  
Vol 78 (3) ◽  
pp. 689-695 ◽  
Author(s):  
E C Böttger ◽  
T Hoffmann ◽  
U Hadding ◽  
D Bitter-Suermann
Keyword(s):  
Immune Complex ◽  
Guinea Pigs ◽  
Complex Disease ◽  
Immune Complex Disease ◽  
Complement Components

scholarly journals ACUTE IMMUNE COMPLEX DISEASE IN RABBITS

1971 ◽  
Vol 133 (3) ◽  
pp. 554-571 ◽  
Author(s):  
P. M. Henson ◽  
C. G. Cochrane
Keyword(s):  
Immune Complex ◽  
Immune Complexes ◽  
Complex Disease ◽  
Immune Complex Disease ◽  
Neutrophil Accumulation ◽  
Blood Leukocytes ◽  
Complement Components ◽  
Arterial Lesions ◽  
Immunological Reactions ◽  
Independent Reaction

By depletion of C3 from rabbits undergoing acute experimental immune complex disease with an anticomplementary factor in cobra venom, it has been possible to demonstrate that deposition of the complexes in arteries and glomeruli does not require the complement components reacting after C2. Immunological reactions, in which platelets release their vasoactive amines, have been examined in rabbits undergoing immune complex disease. A correlation was obtained between the presence of a complement-independent reaction which required blood leukocytes, antigen and platelets, the deposition of immune complexes, and the induction of glomerulonephritis. C3 depletion did, however, have a marked alleviating effect on the severity of the arterial lesions. Neutrophil accumulation and the subsequent necrotizing arteritis were prevented. In contrast, the character and severity of the glomerulonephritis was not altered by depletion of later-acting complement components.

scholarly journals C1q nephropathy: a true immune complex disease or an immunologic epiphenomenon?

2009 ◽  
Vol 2 (4) ◽  
pp. 285-291
Author(s):  
M. Muorah ◽  
M. D. Sinha ◽  
C. Horsfield ◽  
P. J. O'Donnell
Keyword(s):  
Immune Complex ◽  
Complex Disease ◽  
Immune Complex Disease ◽  
C1q Nephropathy

Immunopathology of Immune Complex Disease

1983 ◽  
pp. 371-390
Author(s):  
U. E. Nydegger ◽  
M. D. Kazatchkine ◽  
P. H. Lambert ◽  
P. A. Miescher
Keyword(s):  
Immune Complex ◽  
Complex Disease ◽  
Immune Complex Disease
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