Failure of Somatostatin Analogue Sms 201–995 to Control Cushing's Syndrome Due to Ectopic Release of Acth from a Bronchial Carcinoid

1989 ◽  
Vol 34 (5) ◽  
pp. 533-534 ◽  
Author(s):  
L. Burrell ◽  
C.E. Gray ◽  
J.A. Thomson
Keyword(s):  
Cushing’S Syndrome ◽  
Carcinoid Tumour ◽  
Cushing's Syndrome ◽  
Somatostatin Analogue ◽  
Bronchial Carcinoid ◽  
Thymic Carcinoid ◽  
Ectopic Cushing’S Syndrome

A patient with ectopic Cushing's syndrome secondary to a malignant thymic carcinoid tumour was treated with the somatostatin analogue SMS 201–995. The administration of the drug subcutaneously in increasing doses over a 34 day period failed to control the ACTH or glucocorticoid excess.

DETECTION OF AN ACTH-SECRETING BRONCHIAL CARCINOID TUMOUR EIGHTEEN MONTHS AFTER ADRENALECTOMY FOR CUSHING'S SYNDROME

1971 ◽  
Vol 67 (4) ◽  
pp. 625-633 ◽  
Author(s):  
A. C. M. Vingerhoeds ◽  
P. J. der Kinderen ◽  
J. H. H. Thijssen ◽  
F. Schwarz
Keyword(s):  
Differential Diagnosis ◽  
Cushing’S Syndrome ◽  
Carcinoid Tumour ◽  
Cushing's Syndrome ◽  
Bronchial Carcinoid ◽  
Laboratory Methods ◽  
Ectopic Cushing’S Syndrome ◽  
Course Of Action ◽  
Ablative Surgery ◽  
Acth Secreting

ABSTRACT A patient is described in whom an ACTH-producing bronchial carcinoid tumour was found eighteen months after bilateral adrenalectomy for Cushing's syndrome. A critical review is given of laboratory methods used in the differential diagnosis of ectopic Cushing's syndrome. Finally a course of action is suggested by which such unnecessary ablative surgery might be avoided.

Plurihormonal bronchial carcinoid associated with ectopic Cushing’s syndrome

1999 ◽  
Vol 10 (4) ◽  
pp. 359-365 ◽  
Author(s):  
Donna Battaglia ◽  
Kalman Kovacs ◽  
Eva Horvath ◽  
Eric Poulin ◽  
Harley S. Smyth
Keyword(s):  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Bronchial Carcinoid ◽  
Ectopic Cushing’S Syndrome

scholarly journals Ectopic Cushing's syndrome and pulmonary carcinoid tumour identified by [111In-DTPA-D-Phe1]octreotide.

1998 ◽  
Vol 74 (868) ◽  
pp. 108-110 ◽  
Author(s):  
J. Matte ◽  
F. Roufosse ◽  
P. Rocmans ◽  
A. Schoutens ◽  
D. Jacobovitz ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Carcinoid Tumour ◽  
Cushing's Syndrome ◽  
Pulmonary Carcinoid ◽  
Ectopic Cushing’S Syndrome

scholarly journals THYMIC CARCINOID WITH ACTH-PRODUCING ECTOPIC CUSHING'S SYNDROME AND EMPTY SELLA.

2018 ◽  
Author(s):  
Artak Labadzhyan ◽  
Se-Min Kim ◽  
Jane Rhyu ◽  
Takako Araki ◽  
Ali Mahtabifard ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Empty Sella ◽  
Thymic Carcinoid ◽  
Ectopic Cushing’S Syndrome

Occult eutopic Cushing's syndrome--failure of simultaneous bilateral petrosal sinus sampling to diagnose pituitary-dependent Cushing's syndrome

1997 ◽  
pp. 74-78 ◽  
Author(s):  
C Heppner ◽  
K Becker ◽  
W Saeger ◽  
RW Gunther ◽  
B Allolio ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Carcinoid Tumour ◽  
Cushing's Syndrome ◽  
High Dose ◽  
Acth Secretion ◽  
Cell Adenoma ◽  
Ectopic Acth ◽  
Ectopic Acth Secretion ◽  
Ectopic Cushing’S Syndrome ◽  
Lysine Vasopressin

Simultaneous bilateral inferior petrosal sinus (IPS) sampling has been repeatedly proposed to be a highly specific approach for the diagnosis of Cushing's disease and 100% sensitivity in detecting autonomous pituitary ACTH secretion by an adenoma has been reported in a large series. We now report on a patient suffering from ACTH-dependent Cushing's syndrome in whom repeated bilateral IPS sampling failed to detect a central/peripheral gradient diagnostic for autonomous pituitary ACTH secretion during initial evaluation. Applying lysine vasopressin as the corticotroph secretatogue, the maximum central/peripheral gradient was 1.0 before and 1.1 following stimulation. Moreover, results of high dose dexamethasone and corticotrophin releasing hormone administration suggested ectopic ACTH secretion. Since thorough diagnostic procedures failed to localise a suspected carcinoid tumour, occult ectopic Cushing's syndrome was diagnosed. Eight years later, a pituitary macroadenoma was detected by magnetic resonance imaging (MRI), IPS catheterisation then revealed a maximal central/ peripheral gradient of 9.3 before and 20.4 after the intravenous administration of lysine vasopressin. Resected tumour tissue was classified as a typical densely granulated ACTH cell adenoma. We conclude that repeated MRI scans should be included in the follow-up of patients with a diagnosis of occult ectopic Cushing's syndrome to avoid the risk of overlooking 'occult eutopic Cushing's syndrome'.

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