Basaloid Squamous Cell Carcinoma of the Esophagus a Case Report

2005 ◽  
Vol 91 (1) ◽  
pp. 87-89 ◽  
Author(s):  
Miroslav Bekavac-Bešlin ◽  
August Mijić ◽  
Aljoša Matejčić ◽  
Željko Ferenčić
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Undifferentiated Carcinoma ◽  
Endoscopic Biopsy ◽  
Esophageal Wall ◽  
Basaloid Squamous Cell Carcinoma ◽  
Surgical Specimen ◽  
Carcinoma Of The Esophagus ◽  
Basaloid Squamous

Basaloid squamous cell carcinoma (BSCC) of the esophagus is an extremely rare tumor which should be differentiated from adenoid cystic and small cell undifferentiated carcinoma. We present the case of a 48-year-old male patient with esophageal BSCC. This tumor has specific histological features which may be difficult to recognize by small endoscopic biopsy examination. In our patient the surgical specimen revealed BSCC with an aggressive pattern (invasion of the whole esophageal wall thickness, lymph node metastases and intraneural spread). We proposed chemotherapy and radiotherapy after surgery, which resulted in a survival of 17 months.

Basaloid Squamous Cell Carcinoma of the Uterine Cervix: Report of a Case With Molecular Analysis

2021 ◽  
pp. 106689692199713
Author(s):  
Jijgee Munkhdelger ◽  
Tomoko Shimooka ◽  
Yoshinori Koyama ◽  
Sadakatsu Ikeda ◽  
Yoshiki Mikami ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Uterine Cervix ◽  
Pik3ca Mutation ◽  
Biological Behavior ◽  
Basaloid Squamous Cell Carcinoma ◽  
Surgical Specimen ◽  
Molecular Alterations ◽  
Basaloid Squamous

There is a lack of knowledge about molecular alterations in basaloid squamous cell carcinoma (BSCC) of the uterine cervix. A 72-year-old woman with a history of previous subtotal hysterectomy and current vaginal bleeding was referred to our hospital. Initially, adenoid cystic carcinoma (ACC) was diagnosed upon cervical cytology and biopsy. Chest imaging showed multiple metastatic lesions in both lungs. The surgical specimen showed BSCC with diffuse p16 immunoreactivity and negativity for S-100, c-kit, and neuroendocrine markers. There was a focal minor ACC component, which could have explained the previous cytology and biopsy diagnosis. Next-generation sequencing with two different panels showed coexisting PIK3CA mutation and NTRK2 fusion with 10 additional variants of unknown significance ( ATR, DAXX, FAM123B, JAK1, KEL, MLL2, NOTCH2, PALB2, POLD1, POLE). The MYB gene fusions were not identified. The patient received chemotherapy with TRK inhibitor larotrectinib and carboplatin, which caused shrinkage of metastatic lung nodules. This is the first report of cervical BSCC with extensive molecular workup, which detected multiple genetic events, including targetable ones, which are potentially implicated in the development of a tumor. The accumulation of data and further studies on this tumor are necessary to define its diagnostic criteria and its clinical and biological behavior.

Clinicopahological features of superficial basaloid squamous cell carcinoma of the esophagus

2017 ◽  
Vol 30 (12) ◽  
pp. 1-5
Author(s):  
J. Oguma ◽  
S. Ozawa ◽  
A. Kazuno ◽  
M. Nitta ◽  
Y. Ninomiya ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basaloid Squamous Cell Carcinoma ◽  
Carcinoma Of The Esophagus ◽  
Basaloid Squamous

scholarly journals A Case of Basaloid Squamous Cell Carcinoma of Polypoid Type in the Esophagus

2017 ◽  
Vol 11 (3) ◽  
pp. 559-563
Author(s):  
Ki Hun Lee ◽  
Sang Jin Lee ◽  
Hak Soo Kim ◽  
Sung Eun Kim ◽  
Soo Yong Choi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Endoscopic Examination ◽  
Basaloid Squamous Cell Carcinoma ◽  
Polypoid Mass ◽  
Carcinoma Of The Esophagus ◽  
Ivor Lewis ◽  
Basaloid Squamous

Basaloid squamous cell carcinoma of the esophagus is very rare. Further, polypoid type of esophageal cancer is also rare. We have recently treated a case of basaloid squamous cell carcinoma which presented as a 1.3-cm esophageal polyp. A 48-year-old woman was referred to our hospital because of a polypoid mass at 36 cm distance from the upper incisor on endoscopic examination, and the result of the biopsy was basaloid squamous cell carcinoma. The patient underwent Ivor Lewis operation with lymph node dissection. Two basaloid squamous cell carcinomas, of 1.3 and 0.4 cm, were diagnosed in the final pathologic examination. Regular periodic follow-up showed no evidence of recurrence or metastasis in the 5-month postoperative period.

scholarly journals A CASE OF BASALOID-SQUAMOUS CELL CARCINOMA OF THE ESOPHAGUS RESECTED AFTER CHEMOTHERAPY

1998 ◽  
Vol 59 (6) ◽  
pp. 1536-1542 ◽  
Author(s):  
Junichi NISHIJIMA ◽  
Ichiro FUKUDA ◽  
Eiji KUROKAWA ◽  
Hitoshi YAMAMOTO ◽  
Wakio ENDOH ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basaloid Squamous Cell Carcinoma ◽  
Carcinoma Of The Esophagus ◽  
Basaloid Squamous

Early basaloid squamous cell carcinoma of the esophagus

2001 ◽  
Vol 53 (2) ◽  
pp. 253-254 ◽  
Author(s):  
Shunichiro Komatsu ◽  
Norihiro Yuasa ◽  
Koji Oda ◽  
Hideo Miyake ◽  
Yasuhiro Kurumiya ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basaloid Squamous Cell Carcinoma ◽  
Carcinoma Of The Esophagus ◽  
Basaloid Squamous
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