Distinction of basaloid squamous cell carcinoma from adenoid cystic and small cell undifferentiated carcinoma by immunohistochemistry

1998 ◽  
Vol 29 (6) ◽  
pp. 609-612 ◽  
Author(s):  
William G. Morice ◽  
Jorge A. Ferreiro
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Undifferentiated Carcinoma ◽  
Small Cell ◽  
Basaloid Squamous Cell Carcinoma ◽  
Adenoid Cystic ◽  
Small Cell Undifferentiated Carcinoma ◽  
Basaloid Squamous

Basaloid Squamous Cell Carcinoma of the Esophagus a Case Report

2005 ◽  
Vol 91 (1) ◽  
pp. 87-89 ◽  
Author(s):  
Miroslav Bekavac-Bešlin ◽  
August Mijić ◽  
Aljoša Matejčić ◽  
Željko Ferenčić
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Undifferentiated Carcinoma ◽  
Endoscopic Biopsy ◽  
Esophageal Wall ◽  
Basaloid Squamous Cell Carcinoma ◽  
Surgical Specimen ◽  
Carcinoma Of The Esophagus ◽  
Basaloid Squamous

Basaloid squamous cell carcinoma (BSCC) of the esophagus is an extremely rare tumor which should be differentiated from adenoid cystic and small cell undifferentiated carcinoma. We present the case of a 48-year-old male patient with esophageal BSCC. This tumor has specific histological features which may be difficult to recognize by small endoscopic biopsy examination. In our patient the surgical specimen revealed BSCC with an aggressive pattern (invasion of the whole esophageal wall thickness, lymph node metastases and intraneural spread). We proposed chemotherapy and radiotherapy after surgery, which resulted in a survival of 17 months.

Basaloid squamous cell carcinoma with adenoid cystic‐like features of the head and neck region: A report of two cases

2020 ◽  
Vol 70 (10) ◽  
pp. 767-774
Author(s):  
Kimihide Kusafuka ◽  
Haruna Yagi ◽  
Satoshi Baba ◽  
Hiroshi Inagaki ◽  
Chinatsu Tsuchiya ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Region ◽  
Basaloid Squamous Cell Carcinoma ◽  
Head And Neck Region ◽  
Adenoid Cystic ◽  
Basaloid Squamous

Basaloid Squamous Cell Carcinoma of the Esophagus With or Without Adenoid Cystic Features

2004 ◽  
Vol 128 (10) ◽  
pp. 1124-1130 ◽  
Author(s):  
Tie-Jun Li ◽  
Yong-Xin Zhang ◽  
Julie Wen ◽  
Daniel F. Cowan ◽  
John Hart ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Smooth Muscle ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Smooth Muscle Actin ◽  
Basaloid Squamous Cell Carcinoma ◽  
Muscle Actin ◽  
Adenoid Cystic ◽  
Basaloid Squamous

Abstract Context.—Basaloid squamous cell carcinoma (BSCC) of the esophagus is a rare malignant tumor that morphologically could bear some resemblance to adenoid cystic carcinoma (ACC) originating from salivary glands. Objective.—The purpose of this study is to describe the histologic, immunohistochemical, and ultrastructural findings of BSCCs of the esophagus, with an emphasis on comparing tumors with or without adenoid cystic features. Design.—We reviewed 239 cases of primary esophageal carcinoma and detected 12 cases (5%) of BSCC. The light and electron microscopic findings and immunocytochemical localization of various antigens, including cytokeratins (AE1, AE3), carcinoembryonic antigen, epithelial membrane antigen, S100, smooth muscle actin, and p53, were examined in these BSCC cases. Results.—Histologically, all BSCCs were composed of solid lobules or nests of basaloid cells with well-demarcated outlines surrounded by a fibrous stroma. Seven of 12 tumors showed areas of ACC-like features, that is, cribriform-like pseudoglandular lumina formation and hyaline material surrounding the tumor nests, whereas the remaining 5 tumors were apparently pure basaloid carcinomas. These 2 groups of tumors were histologically and immunohistochemically identical in many aspects, namely, high-grade nuclei of the tumor cells with frequent mitoses, abundant comedo-type necrosis, focal areas of concomitant squamous differentiation, consistent immunoreactivity for cytokeratins, and poor or absent staining for S100 and smooth muscle actin. Ultrastructurally, the basaloid tumor cells exhibited relatively undifferentiated cellular characteristics and undeveloped cell organelles. Conclusion.—Basaloid squamous cell carcinomas of the esophagus frequently have an intimate association with ACC-like patterns, but their histologic, immunocytochemical, and ultrastructural features correspond more to poorly differentiated squamous cell carcinoma than to salivary gland ACC. This distinction is important because genuine ACC is much less aggressive than BSCC.

scholarly journals A comparative analysis of clinicopathological factors between esophageal small cell and basaloid squamous cell carcinoma

Medicine ◽  
2019 ◽  
Vol 98 (8) ◽  
pp. e14363 ◽  
Author(s):  
Hirotaka Ishida ◽  
Atsuko Kasajima ◽  
Yu Onodera ◽  
Takuro Konno ◽  
Shota Maruyama ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Comparative Analysis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Small Cell ◽  
Basaloid Squamous Cell Carcinoma ◽  
Clinicopathological Factors ◽  
Basaloid Squamous
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